The invention provides an externally used composition for adjusting endocrine and a preparation method thereof. The composition comprises the following ingredients: 15-18 weight parts of liquid paraffin, 1-3 weight parts of isopropyl myristate, 1-2 weight parts of monoglyceride stearate, 1-2 weight parts of cetanol, 1-2 weight parts of squalane, 1-2 weight parts of glycerin, 0.1-0.3 weight parts of hyaluronic acid, 1-3 weight parts of xanthan gum, 2-4 weight parts of hexadecyl palmitate, 1-3 weight parts of carbopol 940, 1-3 weight parts of ligustrum lucidum, 2-4 weight parts of raspberry, 2-4 weight parts of Chinese angelica, 1-3 weight parts of resveratrol, 1-3 weight parts of Chinese yam, 3-6 weight parts of clover, 3-6 weight parts of soybean, 2-4 weight parts of black cohosh, 2-5 weight parts of Cordyceps sinensis, 1-3 weight parts of ginseng, 1 weight part of natural vitamin E, 1-3 weight parts of epimeddium, 1-3 weight parts of Saw Palmetto, 1-3 weight parts of water-soluble azone, and 0.1-0.3 weight parts of Pierre BP (antiseptic). The composition disclosed herein has significant curative effects on abdominal pain, not correct color of blood, and menostaxis during menstruation, and morbid leucorrhea caused by cold, cold extremities, sexual apathy, aciesis, insomnia, climacteric metancholia, etc.