34 results about "High contrast imaging" patented technology

An in vivo imaging device having an illumination system that creates a virtual source within a tissue region of a subject in a non-invasive manner. The illumination system transforms a maximum amount of illumination energy from a light source into a high contrast illumination pattern. The illumination pattern is projected onto the object plane in a manner that maximizes the depth to which clear images of sub-surface features can be obtained. The high intensity portion of the illumination pattern is directed onto the object plane outside the field of view of an image capturing device that detects the image. In this configuration, scattered light from within the tissue region interacts with the object being imaged. This illumination technique provides for a high contrast image of sub-surface phenomena such as vein structure, blood flow within veins, gland structure, etc.

An in vivo imaging device having an illumination system that creates a virtual source within a tissue region of a subject in a non-invasive manner. The illumination system transforms a maximum amount of illumination energy from a light source into a high contrast illumination pattern. The illumination pattern is projected onto the object plane in a manner that maximizes the depth to which clear images of sub-surface features can be obtained. The high intensity portion of the illumination pattern is directed onto the object plane outside the field of view of an image capturing device that detects the image. In this configuration, scattered light from within the tissue region interacts with the object being imaged. This illumination technique provides for a high contrast image of sub-surface phenomena such as vein structure, blood flow within veins, gland structure, etc.

This invention provides an infrared illuminator and camera system for imaging of auto vehicle license plates. The system works in ambient light conditions, ranging from bright sunlight, to dim light, to dark, to zero ambient light. It yields high-contrast imaging of the letters and numbers on retro-reflective license plates. The images of the license letter and number combinations can be read manually by a remote operator. They can be converted to text format with optical character recognition computer hardware and software. The text data can then be compared to data files listing license numbers to provide further data about the owner of a licensed vehicle. A decision can be made quickly about whether to allow a vehicle to proceed through a gate, or whether to take other action. The system uses a mono camera that is enhanced for infrared sensitivity and combined with a high power infrared illuminator to maximize range at night, and with shutter speeds set up to capture clear license plate pictures even with fast moving vehicles and even with their headlights on and interfering with human observation of the license plates. Optical filtering to pass infrared in the range of the illuminator and to reduce light outside this range, combines with a lens set up, to avoid vertical smear and sensor overload caused by headlights at night and by highlight reflected glare from the sun in daytime.

An infrared illuminator and camera system for high contrast imaging of non-retro-reflective license plates utilizing a combination of temporal filtering via pulsed LED illumination, spectral filtering using high transmission narrow band pass optical filters placed directly on the CCD sensor, and an IR sensitive camera with adjustable computer controlled settings to produce high definition, high contrast images of a wide range of both retro-reflective and non-retro-reflective surfaces including vehicle license plates, ISO shipping containers, and transport trucks with DOT ID numbers on fenders for use in weigh in motion systems, and can operate in all lighting conditions from total darkness to bright sunlight.

A method is described for producing printed patches to provide a plurality of color markings and high-contrast markings as aligned arrangements of fiducial points. The printed color markings facilitate optical image processing and the printed high-contrast markings facilitate high-contrast image processing. These fiducial points enable a visible area of interest to be located by a person and associated with relevant high-contrast imaging data. This method includes providing a patch; printing at least one arrangement of color markings on the patch; and printing at least one arrangement of high-contrast markings on the patch. According to further features of certain embodiments the markings are aligned, can designate the same point, or can be disjointed.

A method is described for producing printed patches to provide a plurality of color markings and high-contrast markings as aligned arrangements of fiducial points. The printed color markings facilitate optical image processing and the printed high-contrast markings facilitate high-contrast image processing. These fiducial points enable a visible area of interest to be located by a person and associated with relevant high-contrast imaging data. This method includes providing a patch; printing at least one arrangement of color markings on the patch; and printing at least one arrangement of high-contrast markings on the patch. According to further features of certain embodiments the markings are aligned, can designate the same point, or can be disjointed.

An inverted microscope for the high-contrast imaging of objects includes multiple objectives configured to be disposable in an imaging beam path. Each objective has a respective objective pupil associated therewith. A lens system is also provided for generating respective intermediate images of the respective objective pupils. A modulator disposing device, which includes a plurality of modulators, is configured to dispose the modulators at predetermined respective locations on an optical axis corresponding to the locations of the respective intermediate images of the respective objective pupils so as to contrast an object image.

We describe methods and apparatus for high-speed high-contrast imaging one-, two- and three-dimensional imaging enabled by differential interference contrast time encoded amplified microscopy of transparent media without the need for chemical staining, that are suitable for a broad range of applications from semiconductor process monitoring to blood screening. Our methods and apparatus build on a unique combination of serial time-encoded amplified microscopy (STEAM) and differential interference contrast (DIC) microscopy. These methods and apparatus are ideally suited for identification of rare diseased cells in a large population of healthy cells and have the potential to revolutionize blood analysis and pathology including identification of cancer cells, such as Circulating Tumor Cells (CTC) in early stage disease.

An inverted microscope for the high-contrast imaging of objects includes multiple objectives configured to be disposable in an imaging beam path. Each objective has a respective objective pupil associated therewith. A lens system is also provided for generating respective intermediate images of the respective objective pupils. A modulator disposing device, which includes a plurality of modulators, is configured to dispose the modulators at predetermined respective locations on an optical axis corresponding to the locations of the respective intermediate images of the respective objective pupils so as to contrast an object image.

The present invention relates to a reversible fluorescence photoswitch based on the dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems. The dendritic nanocluster according to the present invention consists of two or more dendrimers crosslinked each other to have a globular shape overall, and thereby enhancing the fluorescence intensity and improving the detection sensitivity of the monomeric dendrimers. In addition, the dendritic nanocluster according to the present invention was found to internalize into a living zebrafish by both skin permeation and microinjection, independently. Further, the dendritic nanocluster according to the present invention showed low toxicity and thus it could be useful for both in vivo and in vitro imaging as well as the ex vivo cell tracking applications.

An apparatus for imaging cancer in which cancer tissue is contrasted against adjacent healthy tissue. The apparatus includes illumination and, possibly polarization means configured to provide illumination light on a region of tissue. Detection means are optically coupled to the illumination means, the detection means being adapted to detect reflected light from the tissue (and its polarization state, if applicable) when the tissue is illuminated by the illumination means. Filtering means are optically coupled to the detection means. The filtering means are configured to filter the illumination light and / or reflected light to pass only light within a range, or any subrange between about 1050 to about 1400 nm. Methods for imaging cancer contrast cancer tissue against adjacent healthy tissue.

An apparatus for improving contrast in an image captured by an imaging sensor. The apparatus including: an objective optical system positioned in an optical path of illumination light on an object; an image sensor positioned in the optical path such that light from the objective optical system is incident on the image sensor; a device having a variable transparency positioned at a focal plane of the objective optical system; and a processor configured to: detect a bright spot on the image sensor; and control the device to change a transparency of a portion of the device corresponding to the detected bright spot.

A system for generating an image of ultrastructural biomarkers from a biological sample is provided. The system includes a grid onto which a sample to be imaged may be placed and a cryogenic reservoir into which the grid and sample may be immersed for vitrification of the sample. The system also includes a stage onto which the grid and sample may be situated for subsequent imaging in a high contrast imager to permit identification of ultrastructural biomarkers therein. A method for generating an image of ultrastructural biomarkers from a biological sample is also provided. The generated image of ultrastructural biomarkers may be used subsequently for screening and monitoring diseases, evaluating drug and therapeutic efficacy, and assessing risks associated with a drug or therapeutic candidate, among other things.

The invention provides a terahertz imaging method based on spiral phase contrast imaging and a device. The terahertz imaging method includes the following steps: a collimated terahertz wave beam is subjected to target transmission to obtain a first transmission wave beam; after the first transmission wave beam is travelled for a distance f, modulation is performed by using a first lens to obtain asecond transmission wave beam; after the second transmission wave is travelled for a distance f, modulation is performed by using a spiral phase plate located on a frequency spectrum plane to obtaina third transmission wave beam; after the third transmission wave beam is travelled for a distance f, modulation is performed by using a second lens to obtain a fourth transmission wave beam; and after the fourth transmission wave beam is travelled for a distance f and received by a terahertz camera, imaging is realized. The method introduces the spiral phase contrast imaging technology into terahertz imaging, and the spiral phase contrast imaging can realize the characteristic of high contrast imaging, so that the terahertz high contrast imaging is realized.

The present invention relates to a device, use of the device and a method for high contrast imaging, particularly suitable for imaging of moving object of interest such as gas expanding from a gas jet or physical or chemical or biological processes in material.The device for high-contrast imaging comprises a beam splitter for splitting a beam into a probe beam and a reference-beam, wherein the probe beam is directed to an object; a self-imaging system for receiving the probe beam from the object and imaging the object on itself while in a preferred embodiment, the system preserves the a reflected probe beam divergence. The beam interacts with the object at least twice; and the reflected probe beam is further directed to the splitter after the last interaction; and detection means receiving the probe beam from the splitter.

A system and method are provided for imaging and treatment of tumorous tissue in a patient. In an embodiment, the system includes a radiation source for generating a radiation beam comprising high-energy photons with low energy distributions for high contrast imaging along with high energy distributions for efficient treatment dose delivery. The radiation source includes a charged particle accelerator that generates charged particles having energies of less than 6 megavolts (MV), a target to receive the charged particles and generate the high-energy photons of the radiation beam, and a collimator to emit the radiation beam. The system further includes an imaging device of high detective quantum efficiency to define a target region of the tumorous tissue in the patient using the radiation beam, and a controller to determine the shape and modulate the dose for treatment of the tumorous tissue based on the defined target region, using the radiation beam.

The invention discloses a pupil modulation coronagraph system for high-contrast imaging, and relates to the technical field of coronagraph, the pupil modulation coronagraph system comprises a telescope incident end 1, a fixed star simulation light source 2, a collimating lens 3, an aperture diaphragm 4, a pupil modulator 5, an imaging lens 6 and an imaging detector 7, and the two ends of the system are respectively provided with the telescope incident end 1 and the imaging detector 7. The pupil modulator 5 comprises a plurality of modulation bands with different transmittances, the whole modulation band is mainly composed of a plurality of metal film layers with different extinction coefficients, and the extinction coefficients of the metal film layers from the edge areas of the two sides of the whole modulation band to the middle area of the whole modulation band are gradually increased. The invention further discloses a working method of the pupil modulation coronagraph system for high-contrast imaging. According to the pupil modulation coronagraph system for high-contrast imaging and the working method, the transmittance value and the film layer thickness of a modulation band are synchronously optimized, and strong diffraction light of fixed stars is inhibited by combining selection of different coating materials, so that optimal high-contrast imaging is finally obtained.

The invention provides a method for carrying out high-contrast imaging on a transparent medium surface etching or embossment pattern, which is characterized by comprising the following steps of: S1, constructing a periodically arranged shading plate; S2, constructing a special light source by utilizing a white surface light source and the construction period arrangement shading plate; S3, the special light source is adopted to illuminate an imaging target; S4, adjusting a lens of the camera to focus on the surface of the transparent medium; and S5, adjusting the exposure time of a lens aperture and a camera, and limiting the imaging depth of field within a range of two centimeters before and after the etched surface of the transparent medium so as to reduce the interference of the background on imaging. According to the method, a special light source is constructed for active illumination to improve the imaging stability; the imaging depth of field is controlled by adjusting the aperture, imaging contrast is improved, and background interference is reduced.

The invention discloses a spatial broadband ultra-high contrast imaging method and a coronagraph system. According to the method, a pupil transmittance modulation technology is adopted, change modulation of transmittance is carried out in the two-dimensional space direction of a pupil, inhibition of strong light of a fixed star on the axis is achieved, a two-dimensional shape modulation method based on bright and dark strips is adopted, the pupil plane is composed of the bright and dark strips of a limited strip, and by changing the arrangement density distribution of the bright and dark strips, the modulation transmittance is changed, so that the optimal high-contrast imaging is obtained. The system comprises a simulation fixed star light source, a collimating mirror, an aperture diaphragm, a pupil modulation light filter, an imaging mirror and a detector. Aiming at the application of an ultra-high contrast imaging coronagraph in the technical field of broadband imaging, the invention provides and completes the coronagraph system which is suitable for observation with the bandwidth exceeding 5% and even can cover full-band observation. The system can solve the problem that an existing coronagraph is low in light transmission efficiency.

The invention discloses a spatial full-region ultrahigh-contrast imaging method and a coronagraph system. According to the method, a circular ring band pupil transmittance modulation technology is adopted, transmittance gradual change modulation is carried out in the radial direction of a pupil, inhibition of strong diffraction light of a fixed star is achieved, and energy distribution of the fixed star at the pupil position of the system is changed by adopting a limited-band and bilaterally-symmetrical transmittance modulation band in circular ring band pupil transmittance modulation, and the requirement of optimal high-contrast imaging is met. The limited band and the bilaterally-symmetrical transmittance modulation band are composed of limited transmittance modulation ring bands, the ring band modulation gradually changes from the transmittance of a center band, and the left transmittance and the right transmittance are symmetrically distributed from the center band. The coronagraph system suitable for 360-degree working area observation is provided and completed for the technical problem that an ultrahigh-contrast imaging area is limited, the detection efficiency problem of a space coronagraph is solved, the future planet discovery rate and the observation time utilization rate are improved, and the effective life of an extrasolar planet space detection satellite is prolonged.

The invention provides a cyano styrene derivative, a preparation method and application thereof, a polymer detection probe and a fluorescence detection method, which belong to the technical field of polymer detection. The cyano styrene derivative is of a typical D-pi-A structure, strong electron donors such as methoxyl or triphenylamine are introduced to one side or two sides of dicyanostyrene through double bond connection, meanwhile, the length of a conjugated chain is increased, and a high-quality two-photon imaging probe with a large two-photon absorption sectional area can be obtained. The cyano styrene derivative provided by the invention has different dispersibility in different polymer phases, so that fluorescent molecules doped in different polymers have different fluorescence intensities, and a fluorescence method can be utilized to carry out high-contrast imaging and directly distinguish phase separation forms in polymer blends.

The invention provides a cyanostyrene derivative, a preparation method and application thereof, a polymer detection probe and a fluorescence detection method, belonging to the technical field of polymer detection. The cyanostyrene derivative of the present invention is a typical D-π-A structure, and when dicyanostyrene is connected by double bonds on one side or both sides, a strong electron donor such as methoxy or triphenylamine is introduced, The length of the conjugated chain is increased, which is beneficial to obtain a large two-photon absorption cross-sectional area, and is a high-quality two-photon imaging probe. The cyanostyrene derivatives provided by the present invention have different dispersibility in different polymer phases, so that the fluorescent molecules doped in different polymers have different fluorescence intensities, and the fluorescence method can be used to perform high-contrast imaging and directly distinguish polymerization Phase-separated morphology in blends.

The present invention relates to a reversible fluorescence photoswitch based on the dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems. The dendritic nanocluster according to the present invention consists of two or more dendrimers crosslinked each other to have a globular shape overall, and thereby enhancing the fluorescence intensity and improving the detection sensitivity of the monomeric dendrimers. In addition, the dendritic nanocluster according to the present invention was found to internalize into a living zebrafish by both skin permeation and microinjection, independently. Further, the dendritic nanocluster according to the present invention showed low toxicity and thus it could be useful for both in vivo and in vitro imaging as well as the ex vivo cell tracking applications.

The present invention relates to a device, use of the device and a method for high contrast imaging, particularly suitable for imaging of moving object of interest such as gas expanding from a gas jet or physical or chemical or biological processes in material.The device for high-contrast imaging comprises a beam splitter for splitting a beam into a probe beam and a reference-beam, wherein the probe beam is directed to an object; a self-imaging system for receiving the probe beam from the object and imaging the object on itself while in a preferred embodiment, the system preserves a reflected probe beam divergence. The beam interacts with the object at least twice; and the reflected probe beam is further directed to the splitter after the last interaction; and detection means receiving the probe beam from the splitter.

The invention relates to a device for realizing femtosecond time resolution imaging of a weak phase object based on vortex filtering. The device comprises a detection unit and a pumping unit. After light emitted by the femtosecond laser light source passes through a beam splitter, transmitted light enters the detection unit as detection light, and reflected light enters the pumping unit as pumping light; a vortex filter is added into the detection unit to introduce a geometric phase, and a weak phase object is introduced into a detection light incident plane to realize high-contrast imaging of the weak phase object in a dark background; an ultrafast time resolution optical delay device is introduced into the pumping unit, the optical path between a pumping light path and a detection light path is controlled and adjusted, time resolution of a weak phase object is achieved, and imaging detection of the ultrafast dynamic process of the weak phase object is achieved. The device is applied to detection of weak phase objects in the biological field, such as biological cells and transparent organisms; and high-contrast imaging of a weak phase object in a dark background and imaging detection of an ultrafast dynamic process are realized.

The invention discloses a surface plasmon imaging system based on differential denoising. The surface plasmon imaging system comprises a rotary illumination system, a tube mirror, a beam splitter, an oil immersion microscope objective, a gold film substrate, a high-precision displacement platform and an imaging light path, and a surface plasmon has the characteristics of local field enhancement and sensitivity to environment refractive index change, and can be used for imaging small particles. The system comprises the following steps: firstly, performing rotary illumination on an object by using incident light by using a rotary illumination system, eliminating interference fringes generated by the incident light and scattered light, and obtaining an image without the interference fringes and with a smaller size; and on the basis, using a differential denoising method to quickly move a high-precision displacement platform, so that the background noise of the image is removed, and the signal-to-noise ratio of imaging is improved. According to the imaging system, the signal-to-noise ratio of surface plasmon microimaging is greatly improved by using a differential denoising method, high-contrast imaging can be carried out on nanoparticles with the diameter as low as 22 nm, and the particle size resolution is 10 nm.

A molecular imaging probe with a dendrimer as the core and its application, by connecting four rigid arm molecules on the dendrimer IV and connecting different functional molecules, so as to obtain a low-steric hindrance multi-mode multi-target molecule image probe. The obtained probe has good stability and high imaging contrast. Study the synthesized molecular imaging probes, realize the active targeting of molecular imaging probes to lesion sites by linking targeting molecules and signaling molecules, realize its role in the preparation of drugs for the diagnosis and treatment of different tumor diseases by linking different targeting molecules application.

The invention discloses a high-contrast imaging coronagraph micro-point density modulation system, and relates to the technical field of coronagraph, the high-contrast imaging coronagraph micro-point density modulation system comprises a telescope incident end, two reflectors, a collimating mirror, an aperture diaphragm, a pupil modulator, an imaging mirror and a detector, the number of the reflectors is two, and the reflectors are respectively located between the telescope incident end and the collimating mirror and between the pupil modulator and the imaging mirror; the pupil modulator comprises a plurality of modulation bands, each modulation band is provided with a plurality of bright micro-points and dark micro-points, the range of the number of adjustment bands of the pupil modulator is 10-200, and the invention further provides a working method of the high-contrast imaging coronagraph micro-point density modulation system. According to the micro-point density modulation system for the high-contrast imaging coronagraph, the purpose of transmittance change modulation is achieved by changing the spatial density distribution of light and dark micro-points on a modulation band, and the same modulation effect can be achieved for all working wavelengths; according to the invention, the technical problem that the light transmission efficiency of a traditional coronagraph is limited due to too narrow observation wave band can be thoroughly solved.