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39 results about "Fluoroacetates" patented technology
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Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and very stable. The acid itself, as well as the derivatives that are broken down in the body to the acid, are highly toxic substances, behaving as convulsant poisons with a delayed action. (From Miall's Dictionary of Chemistry, 5th ed)
Printed silver oxide batteries
ActiveUS9786926B2Improve adhesionImprove wettabilitySilver accumulatorsElectrochemical processing of electrodesManufacturing technologyPyridinium
An energy storage device, such as a silver oxide battery, can include a silver-containing cathode and an electrolyte having an ionic liquid. An anion of the ionic liquid is selected from the group consisting of: methanesulfonate, methylsulfate, acetate, and fluoroacetate. A cation of the ionic liquid can be selected from the group consisting of: imidazolium, pyridinium, ammonium, piperidinium, pyrrolidinium, sulfonium, and phosphonium. The energy storage device may include a printed or non-printed separator. The printed separator can include a gel including dissolved cellulose powder and the electrolyte. The non-printed separator can include a gel including at least partially dissolved regenerate cellulose and the electrolyte. An energy storage device fabrication process can include applying a plasma treatment to a surface of each of a cathode, anode, separator, and current collectors. The plasma treatment process can improve wettability, adhesion, electron and / or ionic transport across the treated surface.
Owner:PRINTED ENERGY PTY LTD
Printed silver oxide batteries
ActiveUS20180034067A1Improve adhesionImprove wettabilitySilver accumulatorsElectrochemical processing of electrodesPyridiniumPhosphonium
An energy storage device, such as a silver oxide battery, can include a silver-containing cathode and an electrolyte having an ionic liquid. An anion of the ionic liquid is selected from the group consisting of: methanesulfonate, methylsulfate, acetate, and fluoroacetate. A cation of the ionic liquid can be selected from the group consisting of: imidazolium, pyridinium, ammonium, piperidinium, pyrrolidinium, sulfonium, and phosphonium. The energy storage device may include a printed or non-printed separator. The printed separator can include a gel including dissolved cellulose powder and the electrolyte. The non-printed separator can include a gel including at least partially dissolved regenerate cellulose and the electrolyte. An energy storage device fabrication process can include applying a plasma treatment to a surface of each of a cathode, anode, separator, and current collectors. The plasma treatment process can improve wettability, adhesion, electron and / or ionic transport across the treated surface.
Owner:PRINTED ENERGY PTY LTD
Preparation method of 2-bromo-2,2-difluoroacetyl chloride and 2-bromo-2,2-difluoro acetate and recycling method of waste difluoro trichloroethane
InactiveCN104761446AEnable recyclingIncrease added valuePreparation by hydrogen halide split-offPreparation from carboxylic acid halidesBromoethanePhenol
The invention relates to a preparation method of 2-bromo-2,2-difluoroacetyl chloride and 2-bromo-2,2-difluoro acetate and a recycling method of waste difluoro trichloroethane. The preparation method comprises the following steps: with waste difluoro trichloroethane produced in the production process of dichlorotrifluoroethane as a raw material, carrying out dehydrochlorination to obtain difluoro dichloroethylene, carrying out addition reaction on difluoro dichloroethylene and bromine to obtain difluoro dichlone dibromoethane; reacting difluoro dichlone dibromoethane with sulfur trioxide to obtain 2-bromo-2,2-difluoroacetyl chloride; and reacting 2-bromo-2,2-difluoroacetyl chloride with alcohol or phenol to obtain 2-bromo-2,2-difluoro acetate series products. According to the preparation method and the recycling method, recycling of waste difluoro trichloroethane is realized; 2-bromo-2,2-difluoroacetyl chloride and 2-bromo-2,2-difluoro acetate are prepared by a temperature oscillation method, so that the production cost is reduced; and meanwhile, the preparation method is an environment-friendly technique for producing products.
Owner:JIANGXI SUNWAY CHEM CO LTD
Preparation method of alpha-fluoroacrylate
ActiveCN102731304AHigh purityEfficient removalOrganic compound preparationCarboxylic acid esters preparationDistillationParaformaldehyde
The invention provides a preparation method of alpha-fluoroacrylate. The preparation method comprises the following steps: reacting by adding alpha-fluoroacetate to a mixed solution of an oxalic acid diester and a sodium alkoxide; filtering, washing and drying to obtain a sodium salt; and condensing the sodium salt and a paraformaldehyde, and carrying out reduced pressure distillation to obtain the alpha-fluoroacrylate. The preparation method of the alpha-fluoroacrylate has the characteristics of simplicity, high yield, and no need of special equipment, and is suitable for industrialized production.
Owner:厦门中坤化学有限公司
Preparation method for 5-fluorocytosine
The invention belongs to the technical field of medicinal chemical synthesis, and particularly relates to a preparation method for 5-fluorocytosine. The preparation method comprises the following steps of: dropwise adding ethyl formate in xylene, carrying out a condensation reaction with methyl fluoroacetate under the action of a metal catalyst, and heating, stirring and carrying out heating heat preservation to obtain an intermediate; carrying out chlorination substitution on the intermediate with a chlorinating agent in the presence of an organic amine catalyst to obtain a chlorination product; carrying out ammoniation substitution on the chlorination product in an ammonia gas pressure environment and under the action of phase transfer catalysts (N-alkyl phosphoramide, methylene bridged phosphate and tetrabutylammonium bromide to obtain an ammoniation product; carrying out acidic hydrolysis on the ammoniation product to obtain 5-fluorocytosine. The 5-fluorocytosine prepared by the preparation method disclosed by the invention is high in yield and high in purity; use of highly-toxic fluorine is avoided during the preparation process, thus reducing damage and injury to equipment and operating personnel during a production process.
Owner:SHANDONG JINCHENG PHARMA & CHEM
Preparation method of 5-flucytosine
ActiveCN108033917AReduce usageThe process is environmentally friendlyOrganic chemistryChemical synthesisPotassium fluoride
The invention belongs to the technical field of chemical synthesis of medicines and relates to a preparation method of 5-flucytosine. The preparation method comprises the following steps: utilizing ethyl formate and methyl chloroformate to synthesize 2-chloro-3-oxo methyl propionate, then utilizing oxymethylisourea to close rings to obtain pyrimidine rings, utilizing potassium fluoride to substitute chlorine on the pyrimidine rings, utilizing phosphorus oxytrichloride to substitute hydroxyl groups on the pyrimidine rings, then adding ammonia water to lead chloride to be substituted with aminogroups, and hydrolyzing under an acid condition to obtain a product, namely the 5-flucytosine. The preparation method has the beneficial effects that the methyl chloroacetate is adopted for substituting methyl fluoroacetate to be used as a synthetic raw material of the 5-flucytosine, so that the use of highly-toxic chemicals such as the methyl fluoroacetate is avoided; simultaneously, since the price of the methyl chloroacetate is much lower than the price of the methyl fluoroacetate, the production cost can be saved; by utilization of the synthetic route provided by the invention, the higher-purity 5-flucytosine can be prepared without need of complex aftertreatment steps; simultaneously, the preparation method has higher overall yield and obvious industrial value and is worthy of being promoted and used on a large scale.
Owner:ZHEJIANG XIANFENG TECH
Method for synthesizing 6-ethyl-5-fluoro-4-hydroxy pyrimidine and intermediate thereof
InactiveCN102060784AReduce pollutionRaw materials are cheap and easy to getOrganic compound preparationCarboxylic acid esters preparationPropionyl chlorideFormamidine acetate
The invention relates to a new concise and efficient method for synthesizing 6-ethyl-5-fluoro-4-hydroxy pyrimidine and an intermediate 2-fluoro-3-oxo ethyl valerate thereof. 6-ethyl-5-fluoro-4-hydroxy pyrimidine is an important intermediate for synthesizing a broad-spectrum antifungal drug voriconazole. At present, the methods for synthesizing 6-ethyl-5-fluoro-4-hydroxy pyrimidine have the defects of more reaction steps, complex processes, more three wastes and high cost and are not favourable for industrial production. To solve the above problems, the method provided by the invention comprises the following reaction steps (see the drawing 1): using ethyl fluoroacetate and propionyl chloride as raw materials under the reaction temperature to synthesize 2-fluoro-3-oxo ethyl valerate under appropriate alkali action; and using 2-fluoro-3-oxo ethyl valerate and formamidine acetate as raw materials under the reaction temperature to synthesize 6-ethyl-5-fluoro-4-hydroxy pyrimidine under appropriate reaction system. The method provided by the invention is safe, environment-friendly, concise and efficient.
Owner:NANTONG FINC PHARMA CHEM
Synthetic method and automation device for fluorine-18-ACETATE
InactiveUS20100310428A1Easy to operateShorten production timeProcess control/regulationExhaust apparatusAcetic acidSynthesis methods
An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.
Owner:INST NUCLEAR ENERGY RES ROCAEC
Method for preparing 5-fluorouracil
The invention belongs to the field of organic chemistry synthesis and particularly relates to a method for preparing 5-fluorouracil. The method comprises the following steps: (1) after nitrogen displacement, adding sodium methoxide into toluene, then dripping part of ethyl formate at first, then dripping methyl fluoroacetate and the rest ethyl formate, and stirring after dripping for reaction; (2) adding methyl alcohol and sodium methoxide, stirring, reducing the temperature to 15-25 DEG C, adding urea for reaction, removing a solvent after reaction, re-adding water, cooling, stirring, regulating the pH to 3-4, and filtering to obtain the product. According to the invention, as ethyl formate and methyl fluoroacetate are mixed and dripped, and the dripping temperature is reduced, loss of ethyl formate is reduced, accordingly, reaction of ethyl formate and methyl fluoroacetate is promoted, and the yield is improved to be more than 74.5%; addition of the solvent is reduced, so that the solvent reclamation amount can be remarkably reduced and the manufacturing cost is greatly lowered.
Owner:SHANDONG JINCHENG PHARMA & CHEM
Method for preparing chiral alpha-fluoro-beta-amino acid derivatives
ActiveCN105566179ASimple methodImprove universalityOrganic chemistryOrganic solventEnantioselective synthesis
The invention relates to a method for preparing chiral alpha-fluoro-beta-amino acid derivatives. In an organic solvent, chiral (Rs)-N-(tert-butylsulfinyl)imine, alkyl fluoroacetate and an alkali undergo a reaction at a temperature of -90 to 30 DEG C for 0.5-5h to produce chiral alpha-fluoro-beta-amino acid. Compared with the prior art, the method utilizes alkyl fluoroacetate as an initial raw material and produces the chiral alpha-fluoro-beta-amino acid through an addition reaction of the chiral alpha-fluoro-beta-amino acid and the chiral imine. The method has high efficiency and high universality and is simple. The method utilizes easily available and cheap raw materials, has mild technical conditions and high efficiency and can produce high-optical purity alpha-fluoro-beta-amino acid. The chiral alpha-fluoro-beta-amino acid is a latent bioactive molecule synthesis building block and can be used in the fields of asymmetric syntheses and medicine research and development.
Owner:SHANGHAI UNIV OF ENG SCI
Preparation method of fluoroacetamide hapten and application of monoclonal antibody
ActiveCN109575123AEasy to makeImprove economyOrganic compound preparationSerum albuminCarrier proteinKeyhole-limpet haemocyanin
The invention relates to the technical field of biological chemistry, and particularly discloses a preparation method of fluoroacetamide hapten and application of a monoclonal antibody. The fluoroacetamide hapten is synthesized by taking ethyl fluoroacetate and p-aminophenylacetic acid as main raw materials; the fluoroacetamide hapten and carrier protein bovine serum albumin (BSA) or keyhole limpet hemocyanin (KLH) are coupled through an active lipid method, and thus a conjugate is prepared. Through experimental verification, it shows that the prepared conjugate enables a living body to generate the antibody against fluoroacetamide, that is to say, the prepared conjugate is fluoroacetamide artificial antigen. The prepared fluoroacetamide artificial antigen is suitable for enzyme-linked immunological analysis of fluoroacetamide.
Owner:CHINA AGRI UNIV
Method for synthesizing alpha-amine formyl fluoroacetate compound
InactiveCN104496737AHigh yieldEasy to operateOrganic compound preparationCarboxylic acid amides preparationSolvent freeMalonate
The invention discloses a method for synthesizing an alpha-amine formyl fluoroacetate compound. The method comprises the steps: performing reaction on a primary amino compound and fluoro-malonate which serve as raw materials under a solvent-free condition to prepare the alpha-amine formyl fluoroacetate compound; or performing reaction on a primary amine acid salt compound and the fluoro-malonic ester in the presence of a solvent and an acid-binding agent to prepare the alpha-amine formyl fluoroacetate compound. The method is easy to operate, quick in response and high in yield, can solve the problem that alpha-amine formyl fluoroacetate compound cannot be conveniently and quickly synthesized, and is suitable for easy preparation in a laboratory. The compound disclosed by the invention can be used for synthesizing fluorine-containing organic molecules.
Owner:XIAN MODERN CHEM RES INST
Preparation method for fluoromalonic acid diester
InactiveCN107935853AOrganic compound preparationCarboxylic acid esters preparationOrganic synthesisImpurity
The invention especially relates to a preparation method for fluoromalonic acid diester, belonging to the field of organic synthesis. The preparation method comprises a step of subjecting fluoroacetate and dialkyl carbonate to a condensation reaction in the presence of alkali so as to prepare fluoromalonic acid diester. The preparation method provided by the invention is mild in reaction process;the preparation method has low toxicity and corrosivity due to elimination of conventional chlorination and fluorination steps; and the preparation method does not produce difluoromalonic acid diesterimpurities, has low requirements on factory equipment and is simple and safe to operate.
Owner:LANZHOU CHEMSPECWEIER CHEM CO LTD
Method for preparing alclometasone dipropionate
ActiveCN109678920AShort synthetic routeProcess economy and environmental protectionSteroidsDexamethasonePropanoic acid
The invention provides a method for preparing alclometasone dipropionate. According to the method, alclometasone dipropionate is synthesized by the following seven reaction steps: esterification of 16a-methyl epihydrocortisone as a raw material with propionic acid at position 21; double-oxidization at positions 7 and 11 to obtain diketone; esterification with propionic acid at position 17; enolization and etherification protection at position 3; reduction and acid hydrolysis for deprotection with diketone at positions 7 and 11; dehydrogenation with DDQ (Dichlorodicyanobenzoquinone) at position1; and chlorine substitution at position 7. According to the method for preparing alclometasone dipropionate, the alclometasone dipropionate is synthesized by taking 16a-methyl epihydrocortisone as the raw material through seven steps; compared with a convention method with dexamethasone fluoroacetate as the raw material, the process has the advantages of short synthetic route and economy and environmental protection, simple production and operation, high product yield and the like; in the alclometasone dipropionate produced with the method, the total synthetic yield is increased from original 2.678% to 32-35%, the production cost is less than 20% of that of the traditional method; the solvent used in production can be recycled and reused; the industrial production is easy to implement.
Owner:HUNAN KEREY BIOTECH
Method for researching methanogenesis metabolic pathway by utilizing selective depressants
InactiveCN108070620AThe principle is simpleEasy to controlWaste based fuelFermentationSulfonateVolatile fatty acids
The invention discloses a method for researching a methanogenesis metabolic pathway by utilizing selective depressants. In an anaerobic digestion system for ammonia nitrogen-tolerant sludge, a methodfor researching the methanogenesis metabolic pathway of the anaerobic digestion system through different depressants is utilized; different anaerobic digestion methanogenesis pathways are depressed byadopting depressants BES (Dibromoethane Sulfonate), fluoroacetate and lumazine; a methanogenesis pathway of the anaerobic digestion system can be indirectly analyzed and judged according to the changes of a methane yield and VFAs (Volatile Fatty Acids), and meanwhile, the contribution rate of an AM (Aceticlastic Methanogenesis) pathway and an SAO-HM (Syntrophic Acetate Oxidation-HydrogenotrophicMethanogenesis) pathway to methanogenesis and the significance of an SAO process is clear and definite.
Owner:JIAXING UNIV
Method and device for preparing methyl fluoroacetate
ActiveCN104292104AReduce generationLess quantityOrganic compound preparationCarboxylic acid esters preparationAcetic acidPotassium fluoride
The invention discloses a method and device for preparing methyl fluoroacetate. The preparation method comprises the following steps of (1) adding potassium fluoride, a solvent and a catalyst in a reaction kettle, stirring and heating; (2) adding methyl chloroacetate into the reaction kettle continuously to carry out reaction when the temperature rises to a reaction temperature, performing two-stage condensation on a mixed gas generated by the reaction, wherein methyl chloroacetate in the mixed gas is condensed to form a liquid in a first stage and returned to the reaction kettle to participate the reaction continuously and methyl fluoroacetate is condensed to form a liquid in a second stage to form the product, according to difference of boiling temperatures. According to the preparation method provided by the invention, the obtained methyl fluoroacetate product has high purity; and the technology process is simple and reasonable, has relatively high reaction conversion rate and yield, can be operated and controlled easily, and is suitable for large-scale production.
Owner:DO FLUORIDE CHEM CO LTD
A kind of preparation method and equipment of methyl fluoroacetate
ActiveCN104292104BReduce generationLess quantityOrganic compound preparationCarboxylic acid esters preparationAcetic acidPotassium fluoride
The invention discloses a method and device for preparing methyl fluoroacetate. The preparation method comprises the following steps of (1) adding potassium fluoride, a solvent and a catalyst in a reaction kettle, stirring and heating; (2) adding methyl chloroacetate into the reaction kettle continuously to carry out reaction when the temperature rises to a reaction temperature, performing two-stage condensation on a mixed gas generated by the reaction, wherein methyl chloroacetate in the mixed gas is condensed to form a liquid in a first stage and returned to the reaction kettle to participate the reaction continuously and methyl fluoroacetate is condensed to form a liquid in a second stage to form the product, according to difference of boiling temperatures. According to the preparation method provided by the invention, the obtained methyl fluoroacetate product has high purity; and the technology process is simple and reasonable, has relatively high reaction conversion rate and yield, can be operated and controlled easily, and is suitable for large-scale production.
Owner:DO FLUORIDE CHEM CO LTD
A kind of preparation method of 5-fluorocytosine
ActiveCN108033917BReduce usageThe process is environmentally friendlyOrganic chemistryChemical synthesisPotassium fluoride
Owner:ZHEJIANG XIANFENG TECH
Acetatic abiraterone trifluoroacetate and preparation method and application of same
Provided are acetaic abiraterone trifluoroacetate, a preparation method and an application of same. The acetaic abiraterone trifluoroacetate is obtained through a salt-forming reaction between acetaic Abiraterone and trifluoroacetic acid. The acetaic abiraterone trifluoroacetate undergoes self-purification through recrystallization, and dissociation and recrystallization are performed on the purified abiraterone acetate trifluoroacetate, so that the obtained acetaic abiraterone has a high purity, a high yield and stable quality, and is capable of meeting the requirement for mass production of acetaic abiraterone.
Owner:SHANGHAI ACEBRIGHT PHARMA CO LTD +2
Preparation method of fluoroacetate
InactiveCN102976934AImprove conversion efficiencyHigh specific surface areaOrganic compound preparationCarboxylic acid esters preparationPotassium fluorideSilica gel
The invention relates to a preparation method of fluoroacetate. The invention adopts a solid disperse technology to prepare a potassium fluoride solid dispersion, so that potassium fluoride exists in the form of extremely tiny crystal grains or molecules on the surface of a micropowder silica gel, has a very large specific area, and thus is highly active. The fluoroacetate is prepared from chlorochloracetate and the potassium fluoride solid dispersion under very mild condition, and the preparation method of fluoroacetate is high in fluorine conversion rate, simple in post treatment, and good in finished product quality, and has unexpected effects and very good application prospect.
Owner:王学军
Synthetic method of methyl 2-fluoro-3-hydroxypropionate
ActiveCN105646216BLow costHigh yieldOrganic compound preparationCarboxylic acid esters preparationPropanoic acidSynthesis methods
The invention relates to a synthesis method of 2-fluoro-methyl 3-hydroxypropionate. The method comprises the following two steps: step one: a sodium enol intermediate is generated under an alkaline condition with methyl fluoroacetate and dimethyl oxalate as raw materials; step two: the sodium enol intermediate has a reaction with a paraformaldehyde or formaldehyde aqueous solution in a solvent to generate 2-fluoro-methyl 3-hydroxypropionate. Cheap methyl fluoroacetate and dimethyl oxalate are taken as raw materials, and the solvent with a low cost is used, so that 2-fluoro-methyl 3-hydroxypropionate is low in cost, high in yield and suitable for large-scale production. In particular, generation of 2-fluoro-methyl 3-hydroxypropionate in a reaction of sodium enol and the paraformaldehyde or formaldehyde aqueous solution under an alkaline condition is a breakthrough in the field.
Owner:HUBEI ENG UNIV
Simple and convenient preparation method of fluorine-containing alkyl-1,5-benzodiazepin-2-one
The invention relates to a preparation method of fluorine-containing alkyl-1,5-benzodiazepin-2-one. The method comprises the following steps of dissolving acyl fluoroacetate and substituted o-phenylenediamine in an organic solvent according to a molar ratio of (1.0 to 1.5): (1.0 to 1.2), adding a catalytic amount of L-proline as a catalyst into an obtained first mixture, refluxing, agitating and reacting until the reaction is completed, and then removing the solvent, afterwards, separating an obtained substance through column chromatography, so as to obtain a fluorine-containing alkyl-1,5- benzodiazepin-2-one compound. The preparation method provided by the invention has the advantages that the method is environmentally-friendly. Moreover, raw materials are obtained easily; an organic small molecule is used for catalysis; a reaction condition is mild; the universality is strong; the post treatment is convenient; further, the yield of a product is higher.
Owner:SHANGHAI UNIV
Acetatic abiraterone trifluoroacetate and preparation method and application of same
Provided are acetaic abiraterone trifluoroacetate, a preparation method and an application of same. The acetaic abiraterone trifluoroacetate is obtained through a salt-forming reaction between acetaic Abiraterone and trifluoroacetic acid. The acetaic abiraterone trifluoroacetate undergoes self-purification through recrystallization, and dissociation and recrystallization are performed on the purified abiraterone acetate trifluoroacetate, so that the obtained acetaic abiraterone has a high purity, a high yield and stable quality, and is capable of meeting the requirement for mass production of acetaic abiraterone.
Owner:SHANGHAI ACEBRIGHT PHARMA CO LTD +2
Bemisia tabaci attractant composition and application thereof
The invention discloses a bemisia tabaci attractant composition and application thereof. The attractant composition comprises bemisia tabaci pheromone and a synergist in a mass ratio of 1:(0.1-0.8). Specifically, the bemisia tabaci pheromone is composed of cis-3-hexenyl acetate and cis-3-hexenal in a mass ratio of 9:1; and the synergist is one or more of cis-3-hexene propionate, cis-3-hexene-2, 2-difluoroacetate and cis-3-hexene-2-methyl-3-crotonate. The bemisia tabaci attractant composition is small in dosage and environmentally friendly, can be accurately applied to bemisia tabaci pest situation prediction, mass trapping and mating interference, remarkably improves the bemisia tabaci green control effect, and has important significance for comprehensive treatment of bemisia tabaci.
Owner:INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
A method for synthesizing α-carbamoyl fluoroacetate compound
InactiveCN104496737BHigh yieldEasy to operateOrganic compound preparationCarboxylic acid amides preparationPolyamine CompoundTrifluoroacetic acid
The invention discloses a method for synthesizing α-carbamoyl fluoroacetate compound: using primary amine compound and fluoromalonate as raw materials, reacting under solvent-free conditions to prepare α-carbamoyl fluoroacetic acid ester compound, or react with primary amine acid salt compound and fluoromalonate under the condition of solvent and acid binding agent to prepare α-carbamoyl fluoroacetate compound. The method disclosed by the invention has the advantages of simple operation, fast reaction and high yield, solves the problem of simple and fast synthesis of α-carbamoyl fluoroacetate compound, is suitable for simple preparation in the laboratory, and the compound disclosed by the invention can be used for fluorine-containing Synthesis of organic molecules.
Owner:XIAN MODERN CHEM RES INST
Optimized production method for pest control agent
The present invention provides a method for producing a compound represented by the following formula (I) with a compound represented by the following formula (A) as a starting substance via production of an intermediate represented by the following formula (B) by use of a trifluoroacetic acid ester and a metal base.
Owner:MEIJI SEIKA PHARMA CO LTD
A kind of imine compound substituted by difluoroacetate and preparation method thereof
ActiveCN108794344BImprove compatibilityReduce usageImino compound preparationOrganic solventDifluoroacetic acid
The invention relates to a difluoroacetate substituted imine compound and a preparation method. The preparation method comprises the following steps: dissolving the enamine compound shown in formula A in an organic solvent, then adding an electrophilic fluorine reagent, after the reaction is complete, filtering, washing, and separating to obtain the compound containing difluoroethylene as shown in formula B. Ester substituted imine compounds. The preparation method of the invention has simple operation, simple and easy-to-obtain raw materials, few reaction steps, high conversion rate and reaction yield, good functional group compatibility, wide application range of substrates, avoiding the use of alkali and precious metals, and is environmentally friendly. The obtained compound contains imine and difluoroacetate structures, can be used as an important synthetic building block of active molecules, and has great application prospects in the field of biomedicine.
Owner:TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
Synthetic method and automation device for fluorine-18-ACETATE
InactiveUS8007730B2Efficient integrationEasy to operateProcess control/regulationGaseous chemical processesAcetic acidControl system
An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.
Owner:INST NUCLEAR ENERGY RES ROCAEC
Process for the production of trialkylsilyl(fluorosulfonyl)difluoroacetate
ActiveUS7348446B2Promote conversionSpeed up reactionSilicon organic compoundsDifluoroacetic acidFluoride
A process for the production of trialkylsilyl (fluorosulfonyl)difluoroacetate by contacting (fluorosulfonyl)difluoroacetyl fluoride with siloxane. The amount of (fluorosulfonyl)difluoroacetic acid by-product in trialkylsilyl(fluorosulfonyl)difluoroacetate is reduced by contacting said mixture with trialkylsilyl halide.
Owner:THE CHEMOURS CO FC LLC
Composite solid acid as well as preparation method and application thereof
ActiveCN113751031AAtom economy is highHigh yieldPhysical/chemical process catalystsOrganic compound preparationFluoroacetic acidAluminium fluoride
The invention discloses composite solid acid as well as a preparation method and application thereof. The preparation method of the composite solid acid disclosed by the invention comprises the following steps: adding an oxide and a fluoride into water, filtering to obtain a solid, and heating the obtained solid at the temperature of 150-350 DEG C for 12-100 hours to obtain the composite solid acid, wherein the oxide is one or more of magnesium oxide, aluminum oxide, zinc oxide, iron oxide, copper oxide, titanium dioxide, zirconium dioxide, silicon dioxide, diatomite and montmorillonite; and the fluoride is one or more of magnesium fluoride, calcium fluoride, zinc fluoride, copper fluoride and aluminum fluoride. The composite solid acid can be applied to preparation of difluoroacetate compounds, and the preparation method is high in atom economy, simple in preparation step, suitable for continuous channelization reaction in preparation process, safe in technological process, short in reaction time, high in yield and few in three wastes, and is an environment-friendly preparation method.
Owner:SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI +1
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