The invention provides application of
Metformin in preparation of a
medicine for preventing and treating bovine
enterovirus infection. The compound
Metformin provided by the invention can effectively inhibit the proliferation of bovine
enterovirus, experiments prove that the accumulation of mRNA and dsRNA of BVDV can be obviously inhibited by using
Metformin to pretreat MDBK cells, the formation of
virus particles can be obviously inhibited, the CPE phenomenon is obviously weakened, the final 10mM use effect of Metformin on the MDBK cells is better, BVDV challenge is performed after the Metformin is used for
intragastric administration of a BALB / c mouse, the Metformin can obviously reduce the content of mRNA of the BVDV in visceral tissues of the mouse, through observation of
pathological sections, the Metformin can effectively relieve tissue lesions caused by BVDV infection, which indicates that the Metformin inhibits replication of BVDV in cells and in mice, and the Metformin has high efficiency in the aspect of
virus resistance. The Metformin has the prospect of being developed into the
medicine for preventing and / or treating bovine
enterovirus infection, a new
medicine application is developed for the Metformin, an experimental foundation is laid for developing the efficient and specific anti-bovine enterovirus medicine, and a new view is provided for developing the efficient and specific anti-bovine enterovirus medicine.