31 results about "Dura mater encephali" patented technology

An implantable system for the treatment of hydrocephalus includes a plurality of microneedles in a fixed array relative to each other adapted to extend from the subarachnoid space containing CSF surrounding the brain, through dura mater forming the wall of the superior sagital sinus. A microvalve is associated with a proximal end of each of the microneedles and is adapted to permit the flow of cerebrospinal fluid (CSF) from the subarachnoid space through the wall of the superior sagital sinus and deposited in the venous return of the brain. The method of treating hydrocephalus with the system of this invention also constitutes a part of the invention.

The invention discloses a novel composite biological dura mater. According to the dura mater, a dura mater substitute is prepared by compounding SIS (small intestinal submucosa) and collagen sponge, is relatively close to a natural dura mater, has the characteristics of being degradable, plastic and modifiable and does not need stitching. The product is relatively substantially improved in performances, mechanical strength and safety. An innovative crosslinking manner enables the product degradation time to be consistent with newborn tissue growth time, and the product is better than clinical a same kind of products. The state of the artificial dura mater patch is innovatively designed according to the thickness difference of different parts of human dura mater, and defects of conventional clinical dura mater products are effectively solved.

The invention discloses a biodegradable albumin hydrogel. According to the hydrogel, the gelling time is smaller than 20 seconds, the swelling degree is 50-200%, the burst strength is not lower than 10 kPa, and the degradation time in vitro is smaller than 30 days. Raw materials for preparation of the hydrogel comprise a first component albumin containing a nucleophilic functional group, a hydrophilic polymer containing multiple electrophilic functional groups and a second component of visual reagent mixture, and the two components are physically mixed through a double-component syringe and then undergo covalent crosslinking to form the hydrogel. The physical performance and biodegradable performance of the hydrogel can be regulated through a change of the second component, the naked-eye visibility of the hydrogel is good, and the hydrogel can be applicable to wound closure of different tissue parts in vivo, for example, closure of a celebral dura mater incision.

The invention relates to a preparation and application of a stitchable dura mater repairing material, and belongs to the field of a biomaterial and medical treatment and public health. The invention specifically discloses a preparation and application of a stitchable dura mater repairing material. The preparation comprises: extraction of target collagen, preparation of a compact layer, preparationof a porous layer, freeze-drying of dura mater, crosslinking and sterilization. The dura mater repairing material has a double-layer composite structure, and is good in mechanical property, is stitchable, and can effectively prevent bleeding of a cerebrospinal fluid. The material is high in purity and has a triple helical structure integratedly maintained in the compact layer. The material is good in biological activity and biological compatibility and controllable in degradation, and is a good substitute for cerebral dura mater and spinal dura mater.

The invention relates to a casing pipe type dura mater dissecting device, which comprises a guiding pipe and a dissector capable of being sleeved inside the guiding pipe, wherein the guiding pipe is a hollow arced pipe with two open ends, the cross section of the guiding pipe is of a bow shape, the dissector is arced under a nature state, the cross section of the dissector is of a bow shape, the dissector is provided with an external dissector shell and an internal dissector inner core, and the dissector is provided with the dissector shell with at least one closed end so as to form a dissecting end. The casing pipe type dura mater dissecting device has the advantages that: the dissector can go into a path along a specific path under the guidance of the guiding pipe so as to effectively prevent deviation and unnecessary skull and dura mater separation, the casing pipe type dura mater dissecting device is high in dissecting efficiency, low in damage rate, simple in structure and simple and convenient to operate, is suitable for the skull and dura mater separation of bone holes of different spacings, and can be used for effectively preventing a milling cutter from breaking dura mater or venous sinus to increase the safety of craniotomy.

The invention relates to preparation and application of a dura mater repairing material, belonging to the fields of biological materials, medical treatment and public health. The preparation of the dura mater repairing material specifically comprises the steps of extracting collagen, preparing slurry, carrying out freeze-drying, crosslinking and sterilization on a dura mater, and the like. The obtained dura mater repairing material has a complete triplex structure and the advantages of high mechanical property, good biocompatibility, biodegradability, controllability and the like and can be taken as a substitute of a dura mater and a spinal film.

The invention provides a multilayer anti-infection high-strength artificial dura mater, which comprises three layers including a hydrophobic inner layer facing to the cerebrum, a water-soluble chitosan outer layer backing to the cerebrum and a woven type middle layer. The invention also provides a preparation method of the multilayer anti-infection high-strength artificial dura mater. The preparation method comprises the following steps of preparing the hydrophobic inner layer through electrospinning; preparing water-soluble chitosan fine strips; preparing hydrophobic fine strips; preparing the woven type middle layer; preparing the outer layer on the middle layer by an oriented electrospinning process; finally obtaining the artificial dura mater. The artificial dura mater effectively solves the problem of infection in the dura mater repair process; meanwhile, the strength of the traditional artificial dura mater is improved; free cutting can be performed according to requirements; safety and reliability are realized; the application prospects are wide.

The invention of biological dura mater patch and a preparation method thereof. Raw material of patch does not come from commercial meat animals, but from breeding animals, such as SIS patch of the sow, has natural good mechanical properties; the method uses plant-derived reagents in the decellularization process, no damage to ECM natural structural base, and retain more active ingredients, has a better ability to induce tissue repair and growth; neither uses a cross-linking agent to enhance mechanical properties, nor synthetic detergents used to remove cells; chemical residues and their toxicity are avoided, while more effective ingredients in ECM, especially GAGs be retained. The patch has soft texture and good toughness, easy to sew tightly, and prevent cerebrospinal fluid leakage; and degradation rate is basically synchronized with the growth of the new dura mater, which is more conducive to repair and regeneration of dura mater.

The invention relates to a method for manufacturing a head hierarchical dissection three-dimensional scanning specimen. The method comprises the following steps: selecting materials; sequentially removing skin, superficial fascia, latissimus jugular muscle, parotid gland, superficial vascular nerve, cap aponeurosis, masseter, periosteum and temporal muscle, opening zygomatic arch and mandible, removing sternoclavicular mastoid muscle, parietal bone of cranial top, frontal bone, temporal bone and occipital bone, cutting to open superior sagittal sinus, removing dura mater, brain, mandible, zygomatic major muscle, zygomatic minor muscle, orbiculus oculi muscle, trapezius muscle, capsid muscle, diabdominal muscle, deorbital horn muscle cheekbone, endocranium, and veins, removing styloid process tongue bone muscles, external rectus, arteries, styloid process pharynx muscles and styloid process tongue muscles, removing auricles, opening temporal bones, and performing median sagittal incision; then, trimming and cleaning the dissected specimen, and pasting specimen muscles, blood vessels and nerves to the original corresponding positions; and finally, combining and processing the 3D scanned images into a complete digital 3D model, so that the scanned specimen is complete in shape and structure, free switching can be realized, and observation and learning are facilitated.

The invention provides a collagen-based dura mater and a preparation method thereof. The collagen-based dura mater comprises a collagen mater layer facing a brain tissue side and a composite collagen mater layer facing a skull side, the collagen membrane layer comprises at least two layers of collagen membranes, and the collagen membranes are formed by I-type collagen; the collagen film layer is a compact layer obtained by spraying a bonding medium on at least two layers of collagen films, overlapping and compounding, and rolling; the at least two layers of collagen membranes comprise a first collagen membrane and at least one layer of second collagen membrane, and the first collagen membrane faces the brain tissue side; the thickness ratio of the first collagen membrane to the second collagen membrane is 1: (1.5-2); the composite collagen membrane layer is formed by compounding type I collagen and mineralized collagen particles, and the interior of the composite collagen membrane layer is of a porous structure; after the collagen membrane layer and the composite collagen membrane layer are compounded, the compounded material is sequentially subjected to rolling forming and crosslinking treatment, and the collagen-based dura mater is obtained. The collagen-based dura mater provided by the invention has excellent mechanical properties and anti-adhesion performance.

The dura mater continuous suturing device comprises a suturing head, the suturing head comprises a needle inserting device, a clamping device and a thread hooking device, the clamping device is composed of a clamping plate, the dura mater continuous suturing device further comprises an operator, the operator comprises a needle inserting switch and a clamping switch, a connecting cylinder is arranged between the suturing head and the operator, and the needle inserting switch comprises a first grip and a second grip. The first grip is fixedly connected with the connecting cylinder, the upper end of the second grip is hinged to the upper end of the first grip, the second grip is connected with the thread hooking device through the first transmission mechanism, the clamping switch is hinged to the connecting cylinder, and one end of the clamping switch is connected with the clamping device through the second transmission mechanism. According to the dura mater continuous suturing device, the time-saving, labor-saving, safe and reliable continuous suturing device is provided for existing suturing operation of the dura mater, the structure is simple, the production cost is low, extra consumable expenditure is reduced, and the dura mater continuous suturing device can be applied to clinical application on a large scale.

A dural knife is provided with a handle, protector, and cutting element, wherein the protector is connected to one end of the handle and the cutting element connects to both the handle and the protector. More particularly, the dural knife has a protector shape and blade height that is adapted to safely raising the dura away from the cortex and making an incision in the dura while sliding the protector beneath the dura.

A dural repair device operable with a single hand. The device comprises a handle and an outer arm having an end opening and a mechanism for holding a needle within the outer arm. The device also comprises an inner arm including a heel, a platform, an end opening, and a mechanism for catching a needle. The handle is activatable such that the inner and outer arms couple, the needle is caught by themechanism for catching a needle within the inner arm, and when the inner and outer arms are uncoupled, the needle is transferred from the outer arm to the inner arm.

The invention relates to a casing pipe type dura mater dissecting device, which comprises a guiding pipe and a dissector capable of being sleeved inside the guiding pipe, wherein the guiding pipe is a hollow arced pipe with two open ends, the cross section of the guiding pipe is of a bow shape, the dissector is arced under a nature state, the cross section of the dissector is of a bow shape, the dissector is provided with an external dissector shell and an internal dissector inner core, and the dissector is provided with the dissector shell with at least one closed end so as to form a dissecting end. The casing pipe type dura mater dissecting device has the advantages that: the dissector can go into a path along a specific path under the guidance of the guiding pipe so as to effectively prevent deviation and unnecessary skull and dura mater separation, the casing pipe type dura mater dissecting device is high in dissecting efficiency, low in damage rate, simple in structure and simple and convenient to operate, is suitable for the skull and dura mater separation of bone holes of different spacings, and can be used for effectively preventing a milling cutter from breaking dura mater or venous sinus to increase the safety of craniotomy.

The invention belongs to the technical field of bio-based materials, and particularly relates to an artificial biological dura mater and a preparation method thereof. The artificial biological dura mater is prepared from the following raw materials of bacterial cellulose and collagen according to a mass ratio of (0.1 to 3):10; any crosslinking agent is not added, so that the adverse effect to therepair process of the dura mater by the crosslinking agent is reduced, and the clinical use safety of the dura mater product is improved. The artificial biological dura mater has the advantages that the artificial biological dura mater is prepared by an electrostatic spinning method; the pH (potential of hydrogen), temperature and other technology conditions are strictly controlled, so that the good biocompatibility and mechanical property are realized, the requirement of operation suture in the clinical use process is met, and the leakage of cerebrospinal fluid is effectively prevented.

The invention provides a multi-layered oriented nano-fiber artificial dura mater. The multi-layered oriented nano-fiber artificial dura mater comprises three layers, namely an inner hydrophobic layer,an outer hydrophilic layer and an intermediate woven layer, wherein by virtue of the 'similarity compatibility principle', the inner layer and the outer layer are reliably connected together throughthe intermediate woven layer; and the outer layer adopts a layered structure, a second layer of the outer layer is of a groove structure consisting of oriented nano-fiber thin strips, and the length directions of grooves are consistent with the directions of nano-fibers. The invention also provides a preparation method of the multi-layered oriented nano-fiber artificial dura mater. The preparationmethod comprises the following steps: the inner hydrophobic layer is prepared by electrospinning; the woven layer is prepared; and the outer layer is prepared on the woven layer in an electrospinningmanner, and finally, the artificial dura mater is obtained. According to the artificial dura mater, the groove structure of the outer layer plays fixing and guiding roles on newborn cranial dura tissues; the problem of layering of the artificial dura mater is effectively solved by the intermediate woven layer; and the multi-layered oriented nano-fiber artificial dura mater can be cut at random and has a wide application prospect.

The invention provides a dura graft and a preparation method thereof. The dura graft is prepared from an acellular dermal matrix. The acellular dermal matrix is obtained from allogenic skin by crosslinking treatment, digestion treatment with a protease solution, decellularization with a hypertonic saline solution containing a surfactant, DNA degradation, amino acid nutrition treatment and freeze drying. The invention also provides applications of the dura graft in preparing repair materials used in the treatment of dural damage. The acellular dermal matrix is obtained from human skin tissue and undergoes physicochemical and biochemical treatment, so that all the components that may cause immunological rejection are removed. A fibrous stereoscopic scaffold structure of the original tissue is completely reserved, and new vessels and fibroblasts rapidly grow in the dura graft after implantation. Therefore, the dura graft has good clinical effects.

The invention provides a scaffold material for clinical dural reconstruction and a preparation method thereof, belongs to the field of medical biomaterials, and mainly solves the problems of suture needing and easy adhesion in dural repair currently in clinic. The purpose of dural repair is achieved by providing a bioactive matrix with a certain pore size and stickiness and with addition of anti-adhesion deacetylated chitin on a product layer for a dural receptor. The material prepared by the method has inherent three-dimensional structure in different concentrations of type I collagen and different spaces of type I collagen and deacetylated chitin, is uniform, has a certain stickiness, reduces the operation of surgical suture, increases the anti-adhesion layer of deacetylated chitin on the basis of maintaining the original activity of type I collagen, reduces the probability of adhesion with cranium after operation, has good biocompatibility and is conducive to dural repair and reconstruction.

The invention provides a novel biofilm material, belongs to the field of medical biomaterials, and mainly solves the problems of suture needing and easy adhesion in dural repair currently in clinic. The purpose of dural repair is achieved by providing a bioactive matrix with a certain pore size and stickiness and with addition of anti-adhesion deacetylated chitin on a product layer for a dural receptor. The material prepared by the method has inherent three-dimensional structure in different concentrations of type I collagen and different spaces of type I collagen and deacetylated chitin, is uniform, has a certain stickiness, reduces the operation of surgical suture, increases the anti-adhesion layer of deacetylated chitin on the basis of maintaining the original activity of type I collagen, reduces the probability of adhesion with cranium after operation, has good biocompatibility and is conducive to dural repair and reconstruction.

The invention discloses a multifunctional craniotome. The multifunctional craniotome comprises a shell, a motor is installed at one end of the shell, the output end of the motor is fixed to a rotary shaft, and a cutting knife fixedly sleeves one end of the rotary shaft; a support is arranged at the top of the shell and slidably connected with the shell, an adjusting block sleeves and is slidably connected to one end of the support, a telescopic rod is vertically fixed to the bottom of the adjusting block, and a fixed rod is installed at the other end of the support; a movable rod is inserted into the middle of the fixed rod, a touch plate is fixed to one end of the movable rod, a limiting block fixedly sleeves one end of the movable rod, and a spring is arranged at the outer side of the movable rod; one end of the spring is fixed to the limiting block, the other end of the spring is fixed to the inner wall of the fixed rod, a touch spot is installed at one end of the limiting block, and a switch is installed on the inner wall of the fixed rod. By means of the multifunctional craniotome, when the cutting knife approaches dura mater encephali, a user can be reminded to be careful, the efficiency of craniotomy is improved, and the cutting knife is prevented from damaging dura mater encephali.

The invention discloses a multifunctional artificial dura mater. The dura mater comprises a dura mater sheet, the dura mater sheet is prepared from a cytoskeleton layer, a waterproof material layer, anano-silver dressing, a nerve growth factor layer, an anti-adhesion layer, an anti-adhesion drug and a hemostatic drug, wherein the waterproof material layer has a good waterproof effect, the nano-silver dressing has the effects of a strong bactericidal effect, no drug resistance, strong permeability and long antibacterial action time, the nano-silver dressing has the effects of promoting self circulation of tissue around a wound, activating and promoting cell growth and promoting wound healing after being combined with the nerve growth factor layer, the anti-adhesion layer has the effect ofpreventing adhesion to brain tissue, and the hemostatic drug has the effect of hemostasis. According to the dura mater, the multiple structures cooperate with one another, so that the artificial duramater has multiple functions of stopping bleeding, accelerating wound healing and resisting water.

The present invention provides minimally invasive subdural evacuating systems and methods of use thereof. The subdural evacuating systems include a cutting component and a rod component, wherein the rod component provides an external physical indicator that the surface of the dura mater has been reached, permitting the cutting component to accurately pierce the dura mater with minimal to no risk of damaging any adjacent anatomy.

The invention discloses a double-layer artificial dura mater and a manufacturing method thereof and belongs to the technical field of medical product manufacturing. The double-layer artificial dura mater is composed of two layers of pig-derived pericardium and polydimethylsiloxane bonded with the two layers of pig-derived pericardium. The preparation method of the double-layer artificial dura mater comprises the following steps that a polydimethylsiloxane solution A and a polydimethylsiloxane solution B are mixed, bubbles are removed, the mixture is arranged between two layers of pig-derived pericardium in a coating mode, after bonding, and the pig-derived pericardium is cured in an oven. The double-layer artificial dura mater has the advantages of simplicity and convenience in operation,clinical practicability, easiness in separation during operation, capability of shortening the operation time and adhesion prevention. The double-layer artificial dura mater is mainly used for conveniently and quickly separating scalp from dura mater and preventing cerebrospinal fluid leakage or postoperative long-term titanium plate exposure when skull repair is carried out on a patient with skull deficiency for the second time.

A non-injury neurosurgery dura mater crochet needle comprises a needle body, the needle body is of a crescent structure, the head of the needle body is sharp, and the tail end of the needle body is connected with a pulling and holding part. A limiting part is arranged on the inner side of the needle body, the limiting part is of a crescent structure which is parallel to the arc of the needle body at intervals, the head of the limiting part is round and blunt, and the tail end of the limiting part is fixedly connected with the needle body; the distance between the head of the limiting part and the head of the needle body is smaller than the thickness of the dura mater, and the distance between the limiting part and the needle body is smaller than the thickness of the dura mater. When the head of the needle body is used for puncturing and lifting the dura mater, on one hand, the head of the limiting part can stop and limit the dura mater to prevent the head of the needle body from puncturing the dura mater to damage brain tissues below, and on the other hand, the distance between the limiting part and the needle body is smaller than the thickness of the dura mater to prevent the dura mater from being damaged. Part of the dura mater after puncture can enter the space between the needle body and the limiting part, the dura mater can be thoroughly prevented from being punctured, and the purpose of protecting the brain tissue below is achieved.

A composite dura substitute implant for implantation at a dura defect site having a porous layer that provides an osteoconductive scaffold for bony ingrowth, a porous layer that provides a scaffold for regeneration of collagen at a dura surface, and an intervening layer for preventing cerebrospinal leakage is disclosed. The composite dura substitute implant facilitates regeneration of dura mater and promotes osteointegration with bony tissue. Methods of manufacturing such an implant and methods of treatment using such composite dura substitute implants are further disclosed.

The invention relates to a method for preparing dura mater with type I collagen and chitosan and belongs to the field of medical biomaterials. The method mainly helps to solve the problem that clinical dura mater repair requires stitching and is prone to causing adhesion. By providing a dura mater receptor with certain porosity and viscosity and a layer of bioactive matrix added anti-adhesion chitosan, the aim of dura mater repair can be achieved. The prepared dura mater is in a three-dimensional structure inherent in type I collagen of different concentrations, as well as type I collagen andchitosan in different spaces, thereby being uniform with certain viscosity and reducing surgical suture operation; by adding a chitosan anti-adhesion layer on the basis of keeping the original activity of the type I collagen, the possibility of postoperative adhesion to cranium can be reduced, high biocompatibility can be achieved, and dura mater repair and reconstruction can be benefited.