Scaffold material for clinical dural reconstruction and preparation method thereof

Abstract

The invention provides a scaffold material for clinical dural reconstruction and a preparation method thereof, belongs to the field of medical biomaterials, and mainly solves the problems of suture needing and easy adhesion in dural repair currently in clinic. The purpose of dural repair is achieved by providing a bioactive matrix with a certain pore size and stickiness and with addition of anti-adhesion deacetylated chitin on a product layer for a dural receptor. The material prepared by the method has inherent three-dimensional structure in different concentrations of type I collagen and different spaces of type I collagen and deacetylated chitin, is uniform, has a certain stickiness, reduces the operation of surgical suture, increases the anti-adhesion layer of deacetylated chitin on the basis of maintaining the original activity of type I collagen, reduces the probability of adhesion with cranium after operation, has good biocompatibility and is conducive to dural repair and reconstruction.

Description

technical field [0001] The invention relates to a kind of deacetylated chitin and type I collagen are mixed in a certain proportion to form the structural reconstruction of deacetylated chitin and type I collagen, and then the type I collagen that is not combined with the deacetylated chitin is separated by physical methods to form Biofilm material prepared by multi-chitin with type I collagen layer and type I collagen layer method. It is a light yellow, soft, porous, viscous product with good biocompatibility. A scaffold material that can be used for clinical dura mater reconstruction and a preparation method thereof. It belongs to the field of medical biomaterials. Background technique [0002] At present, the dura mater replacement materials used in clinical practice in China are usually bovine pericardium, Yang pericardium, porcine pericardium, bovine peritoneum, sheep peritoneum, mesentery, etc. instead of dura mater for dura mater repair, but these materials all need...

AI Technical Summary

Problems solved by technology

[0002] At present, the dura mater replacement materials used in clinical practice in China are usually bovine pericardium, Yang pericardium, porcine pericardium, bovine peritoneum, sheep peritoneum, mesentery, etc. instead of dura mater for dura mater repair, but these materials all need to be sutured, and these materials are relatively hard and difficult. Fully adhered to the surface of brain tissue and prone to adhesion