Celebral dura mater sealing hydrogel and a preparation method and application thereof

Abstract

The invention discloses a biodegradable albumin hydrogel. According to the hydrogel, the gelling time is smaller than 20 seconds, the swelling degree is 50-200%, the burst strength is not lower than 10 kPa, and the degradation time in vitro is smaller than 30 days. Raw materials for preparation of the hydrogel comprise a first component albumin containing a nucleophilic functional group, a hydrophilic polymer containing multiple electrophilic functional groups and a second component of visual reagent mixture, and the two components are physically mixed through a double-component syringe and then undergo covalent crosslinking to form the hydrogel. The physical performance and biodegradable performance of the hydrogel can be regulated through a change of the second component, the naked-eye visibility of the hydrogel is good, and the hydrogel can be applicable to wound closure of different tissue parts in vivo, for example, closure of a celebral dura mater incision.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an albumin sealing gel, a preparation method and application thereof. Background technique [0002] As a biocompatible material, hydrogel is a kind of three-dimensional network structure polymer with hydrophilic groups. Due to the physical cross-linking and chemical cross-linking between polymer chains, hydrogel can be swelled by water but Insoluble in water and maintains a certain shape. In medicine, hydrogels can be used for wound dressing, anti-adhesion after surgery, hemostasis during surgery, tissue filling, and prevention of interstitial fluid leakage or gas leakage, etc. [0003] According to the formation principle, hydrogels can be divided into two categories: chemically cross-linked hydrogels and physically cross-linked hydrogels. Physical crosslinking can be divided into thermosensitive hydrogels and molecular self-assembled hydrogels. Physical hydrogels are combined ...

AI Technical Summary

Problems solved by technology

[0009] Since the sealing agent gel is mostly colorless and transparent (such as Baxter’s Coseal Surgical Vascular Sealing Agent), it is difficult to observe with the naked eye after spraying on the tissue wound, so it is not easy to identify the position of gel spraying and the thickness of the formed gel

For dura mater sealants, if the thickness of the gel is too large, it may cause pressure on the brain tissue. If the thickness of the gel spray is too small, the bursting strength after sealing may be low, and the purpose of closing the wound cannot be achieved.

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