The invention discloses a traditional Chinese medicine preparation for treating a dry eye disease and a preparation method, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine preparation is composed of the effective components of lycium barbarum leaves, plantain herbs, tonkin tinomiscium stems, common aeschynomene herbs, chrysanthemum leaves, cassia seeds, herbs of sessile skullcap, ash bark, coffee senna seeds, Japanese roses, selfheal, paper mulberry stems, seeds of Japanese apricot, mulberry leaves, Nostoc sphaeroides and mirabilitum dehydratum. According to the traditional Chinese medicine preparation for treating the dry eye disease, the medicine preparation is appropriate, the medicines are complemented with one another, the efficacy of clearing heat, brightening the eyes, dispelling wind and heat, relieving swellings and pains of the eyes, soothing the liver, benefiting the gallbladder, dispelling pathogenic wind for improving eyesight, dispersing blood stasis, stopping the pains and the like is achieved, the medicines are compatible and directly reach diseased regions, the traditional Chinese medicine preparation can treat the symptoms of glassy eyes, the eye-burn feeling, dry eyes, dry spots of corneas, swollen eyes, cracked and chapped skins, dryness and swollen with sore of eyes, fatiguability and the like caused by the dry eye disease, the traditional Chinese medicine preparation for treating the dry eye disease has the advantages of being rapid in efficacy, high in cure rate, free of toxic and side effects, safe, convenient, low in cost and easy to prepare.