54 results about "Benzodioxan" patented technology

Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, y, n, m, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

An object of the invention is to provide a manufacturing method of an organic EL display device by fabricating a low molecular weight light emitting material on a lower electrode of an organic EL display device by an inkjet method. In order to achieve this object, in an organic EL display device including an organic material layer, the organic material layer is configured of a mixture of a low molecular weight material and a specified organic material. Concretely, at least one compound selected from 1,2,3-trimethoxytoleune, 1,2,3, 5-tetramethoxybenzene, 1,2-dimethoxy-5-bromobenzene, 3,4-dimethoxy-6-bromotoluene, 1,2,3-trimethoxy-5-bromo-benzene, and 3-bromo-1,2-benzodioxane is contained.

By using a charge-transporting thin film which is made of charge-transporting varnish containing, as an electron-acceptor material, a 1,4-benzodioxane sulfonic acid compound represented by the formula (1) below especially in an OLED device or a PLED device, there can be realized excellent EL device characteristics such as low driving voltage, high luminous efficiency and long life.

Compounds of the formula I:are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

The invention relates to a one-pot preparation method of 2,2-difluoro-1,3-benzodioxole. The one-pot preparation method of 2,2-difluoro-1,3-benzodioxole is characterized by comprising the following steps: adding piperonyl cyclonene, phosphorus oxychloride and phosphorus pentachloride in a lined polytetrafluoroethylene stainless steel bottle, rising temperature to reflux, ending the reaction when the content of piperonyl cyclonene taken as a raw material is detected to be less than 0.2% by GC, carrying out vacuum rectification on a reaction solution to distill off phosphorus trichloride which is a byproduct and phosphorus oxychloride taken as a solvent; cooling to the temperature of 0 to 5 DEG C after the vacuum rectification is finished, dropwise adding hydrogen fluoride liquid at the vacuum degree of minus 0.1 to minus 0.09MPa, then carrying out heat preservation and releasing the byproduct, namely hydrogen chloride; then dropwise adding a saturated sodium carbonate aqueous solution, adjusting the PH value of the solution to be 6.5 to 7.5, stirring and standing to be stratified, taking an organic layer and distilling to obtain a finished product, namely 2,2-difluoro-1,3-benzodioxole which is colorless and transparent liquid. The one-pot preparation method of 2,2-difluoro-1,3-benzodioxole disclosed by the invention has the advantages of low reaction temperature, high safety and improved yield.

Compounds of the formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

The invention belongs to the technical field of organic drug synthesis, and particularly relates to a guanoxan sulfate synthesis method. The method comprises steps as follows: 1), 2-hydroxymethyl-1,4-benzodioxane and thionyl chloride have a chlorination reaction under the condition of existence of a solvent I, and 2-chloromethyl-1,4-benzodioxane is obtained; 2), 2-chloromethyl-1,4-benzodioxane and guanidine are condensed under the condition of existence of alkali and a solvent II, guanoxan is obtained, guanoxan and sulfuric acid are salified, and a finished product guanoxan sulfate is obtained. According to the guanoxan sulfate synthesis method, technological synthesis steps are simple, a route is short, raw material toxicity is relatively lower, and the yield and the purity of the product are high.