31 results about "Arterial elasticity" patented technology

Provided is a radial arterial pulse sensing apparatus for noninvasive and continuous measurement of blood pressure and arterial elasticity. The apparatus includes two pressure sensor for detecting radial arterial pulses, two cuffs that are disposed under the respective pressure sensors and expandable by application of external pressure, a motor unit for providing proper pressure to expandable pouches under the respective pressure sensors in a state where a wrist band having the pressure sensors is put on a wrist, a pulse wave velocity calculating unit that calculates a pulse wave transfer velocity to attain a blood pressure value using an output from the pressure sensors, and an augmentation index calculating unit that estimates the blood pressure value by finding a time point of a reflective wave of the pulses using the outputs from the pressure sensors.

Vitamin K is effective in counteracting cardiovascular disorders such as the reduction in arterial elasticity normally associated with the aging process. A pharmaceutical composition or nutritional formulation comprising vitamin K can be used to combat age-related stiffening of the arteries, and the consequences thereof, namely pulmonary congestion, hypertension, left ventricular hypertrophy, congestive (right sided) heart failure, left sided or left ventricular failure, chronic cardiac failure, angina pectoris, myocardial infarction, Mönckeberg's sclerosis and stroke. In various embodiments, vitamin K can also be used to reduce or reverse calcification of a blood vessel in pre-existing cardiovascular disorders such as arteriosclerosis.

An optimized elastic modulus reconstruction procedure can estimate the nonlinear elastic properties of vascular wall from intramural strain and pulse wave velocity (PWV) measurements. A noninvasive free-hand ultrasound scanning procedure is used to apply external force, comparable to the force in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. PWV is estimated at the same location where intramural strain is measured. The reconstructed elastic modulus is optimized and the arterial elastic modulus can be determined and monitored using a simple dual elastic modulus reconstruction procedure.

The invention provides an arterial elasticity evaluating device based on pulse analysis. The device comprises a left-and-right channel pulse signal detecting module, a computer and a data storage card, wherein the left-and-right channel pulse signal detecting module is connected with an analog-digital conversion module and used for collecting pulse signals of bilateral limbs of a subject; the data storage card is used for storing the pulse signals of the subject and a created arterial elasticity evaluation report; the analog-digital conversion module, the data storage card and a printer are all connected with the computer; the computer is used for performing real-time analysis on the pulse signals, displaying and storing, and printing control, as well as realizing evaluation on pulse signal quality, normalization of the pulse signals, creation and analysis of a pulse template, adjustment of wavelet characteristic parameters, arterial elasticity evaluation and creation of the evaluation report. With the adoption of the device, the pulse signals can be collected from different positions in both sides of the subject and then analyzed and treated on real time, so as to accurately evaluate the arterial elasticity of the bilateral limbs of the subject.

Vitamin K is effective in counteracting the reduction in arterial elasticity normally associated with the aging process. A pharmaceutical composition or nutritional formulation comprising vitamin K can be used to combat age-related stiffening of the arteries, and the consequences thereof, namely pulmonary congestion, hypertension, left ventricular hypertrophy, congestive (right sided) heart failure, left sided or left ventricular failure, chronic cardiac failure, angina pectoris, myocardial infarction, Mönckeberg's sclerosis and stroke.

An optical imaging system and a method for generating a report regarding elasticity of arteries in the brain of a subject under test. Light output from the light source of the imaging system non-invasively illuminates at least one blood vessel or region of interest in the brain and, upon the interaction with the vessel, is registered with an optical detector to obtain a shape parameter of a hemodynamic pulse in the vessel. The shape parameter is further correlated to an elasticity parameter of the blood vessel(s) feeding the brain region of interest and presented in a form of report that may be a two- or a three-dimensional image of the parameter across the tested region of the brain.

A system and method for calculating the arterial compliance, stiffness, and arterial flow and resistance indices for any artery in issue of a subject having a blood pressure monitoring device configured to calculate systolic and diastolic blood pressure readings for an artery of the subject, a blood flow velocity monitoring device configured to calculate the velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject's heart muscle, peak-systolic velocity, and the velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of the subject's heart muscle, end-diastolic velocity, and a central processing unit comprising a computer readable program embodied within the central processing unit configured to calculate the arterial compliance, stiffness, and arterial flow and resistance indices as a function of the area of the artery under initial systolic and end diastolic pressure, the area of the artery generating arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases, peak-systolic and end-diastolic arterial flow velocities, and systolic and diastolic blood pressure.

PROBLEMS TO BE SOLVED: A finger arterial elasticity measuring program, a finger arterial elasticity measuring device and a finger arterial elasticity measuring method are provided for making it possible to measure an elasticity index of a finger artery in accordance with a pulse wave of a finger artery without measuring a blood pressure in evaluating the elasticity of the finger artery related to the degree of arterial sclerosis in an easy and least expensive manner.MEANS FOR SOLVING THE PROBLEMS: A computer functioning by a finger arterial elasticity measuring program includes a pulse wave data memory unit 42, a cuff pressure data memory unit 43, a normalized pulse volume (NPV) calculating unit 52 for dividing an amplitude (ΔI) of an alternate component of a pulse wave by an average value of direct components (I) to calculate NPV, a relative cuff pressure (Pr) calculating unit 53 for calculating a difference between a cuff pressure at the maximum amplitude of the pulse wave and each cuff pressure as Pr, an FEI calculating unit 54 for calculating a linear regression slope (n) of the following expression (1) as an elasticity index of a finger artery: ln(NPV)=ln(bn)−n·Pr . . . (1) where b is a constant.

An optical imaging system and a method for generating a report regarding elasticity of arteries in the brain of a subject under test. Light output from the light source of the imaging system non-invasively illuminates at least one blood vessel or region of interest in the brain and, upon the interaction with the vessel, is registered with an optical detector to obtain a shape parameter of a hemodynamic pulse in the vessel. The shape parameter is further correlated to an elasticity parameter of the blood vessel(s) feeding the brain region of interest and presented in a form of report that may be a two- or a three-dimensional image of the parameter across the tested region of the brain.

The invention discloses a real-time monitoring method and system based on multiple physiological parameters. The method comprises the steps of obtaining an electrocardio signal and a pulse oximeter signal tracing signal of an individual in real time, and outputting the signals for display; obtaining individual self-factors and environmental factors in real time; updating a crowd coefficient in real time based on the MQTT protocol push by Internet of things; monitoring the heart rate, blood pressure, respiratory rate and blood oxygen through the electrocardiosignal and the pulse oximeter signal tracing signal and by combining the crowd coefficient updated in real time, and outputting the heart rate, blood pressure, respiratory rate and blood oxygen for display, wherein the crowd coefficient is a reference coefficient related to arterial elasticity and changes with the individual self-factors and environmental factors any time. According to the real-time monitoring method and system based on the multiple physiological parameters, the crowd coefficient is updated in real time online based on the MQTT protocol push by Internet of things, and many kinds of physiological parameters are monitored and updated in real time.

The invention discloses an oral medicine for treating varicosities, and belongs to the technical field of traditional Chinese medicine. The oral medicine is prepared from the following raw materials: fructus aurantii, rhizoma atractylodis, radix pseudostellariae, the fruit of Chinese wolfberry, the root of bidentate achyranthes, fresh ginger, ligusticum wallichii, fingered citron, pericarpium citri reticulatae viride, golden cypress, radix paeoniae rubra, cassia twig, the root of red-rooted salvia, Chinese thorowax root, curcuma zedoary, radix ophiopogonis, angelica sinensis, the dried rehmannia root, 15-25 g of radix lithospermi, coix seeds, astragalus membranaceus,evodia rutaecarpa, oriental wormwood and liquorice. After the medicines are mixed, the oral medicine for treating varicosities, disclosed by the invention, has synergistic effect in drug function, and has effects of clearing away heat and toxicity, activating blood circulation, stimulating meridians, removing blood stagnate, relieving pain, and promoting pus discharge and tissue regeneration; through the adoption of the oral medicine for treating varicosities, disclosed by the invention, the symptoms such as soreness, swelling, bloating and pain are eliminated, the arterial elasticity is improved, black purple and callous skin becomes more normal, and the purpose of completely healing varicosities is achieved.

The invention provides a method to measure arterial elasticity and arteriosclerosis includes a measuring step and a sampling step to obtain a pulse waveform which represents the displacement of an arterial wall during elastic dilation and contraction. The method of the invention also includes a first differentiation step and a second differentiation step to respectively obtain a first differential pulse waveform and a second differential pulse waveform. The evaluation data is obtained when the arterial wall dilates to the maximum thereof. In an evaluating step, the maximum elastic force represented by the second differentiation of the maximum displacement of the arterial wall is divided by the maximum displacement of the arterial wall to obtain an arterial elasticity coefficient to determine extent of arteriosclerosis and prevent cardiovascular diseases. The present invention has advantages of noninvasive and direct evaluation to arterial elasticity, easy operation, high accuracy and low cost and thus has very high utility.

The present invention relates to the new use of alpha-ketoglutarate, amides, and salts and mixtures thereof for the manufacture of a pharmaceutical preparation or a food or feed supplement for the in vivo therapeutic improvement of blood vessel elasticity, in particular arterial elasticity in a subject in need thereof. Improving the blood vessel elasticity may be used in the for the treatment and / or prophylaxis of hypertension, pulmonary arterial hypertension, cardiovascular disease, retinal vascular disease, heart failure, atherosclerosis, ventricular hypertrophy, stroke, arterial aneurysm, kidney failure, nephrosclerosis and diseases related to hypertension.

The invention discloses bacillus natto with MK-7 production capacity and application of bacillus natto. The bacillus natto is named as bacillus natto BLCC1-0053 and was already preserved at China Center for Type Culture Collection on January 16, 2014 with a preservation number of CCTCC M 2014028. The bacillus natto BLCC10053 has the capacity for producing MK-7, the MK-7 is one of conventional active ingredients for vitamin K2, is easy to absorb by the human body, can improve the bone health, prevent the osteoporosis, inhibit the angiosteosis, maintain the arterial elasticity, prevent the arteriosclerosis and protect the cardiovascular health. The bacillus natto can produce MK-7, the yield reaches up to 3.68733mg / g, and the VK2 needed by the metabolism of the human body can be supplemented, so that an effect for preventing and treating various diseases can be achieved.

The invention discloses an application of des-O-methyllasiodiplodin in preparation of a medicament for treating hypertension. Experimental studies show that the des-O-methyllasiodiplodin can well reduce caudal arterial blood pressure, central aortic systolic blood pressure, central aortic diastolic blood pressure, central aortic mean blood pressure and pulse wave velocity of spontaneously hypertensive rats (SHR), improve the artery elastic function, reduce the aortic media thickness and vascular wall collagen fibers and increase the inside diameters of blood vessels, and has a good effect of preventing and treating the hypertension. Obvious adverse response is avoided in the experimental process, and the des-O-methyllasiodiplodin is expected to be developed into a new-generation safe and effective medicament for preventing and treating the hypertension.

The invention provides an arterial elasticity evaluating device based on pulse analysis. The device comprises a left-and-right channel pulse signal detecting module, a computer and a data storage card, wherein the left-and-right channel pulse signal detecting module is connected with an analog-digital conversion module and used for collecting pulse signals of bilateral limbs of a subject; the data storage card is used for storing the pulse signals of the subject and a created arterial elasticity evaluation report; the analog-digital conversion module, the data storage card and a printer are all connected with the computer; the computer is used for performing real-time analysis on the pulse signals, displaying and storing, and printing control, as well as realizing evaluation on pulse signal quality, normalization of the pulse signals, creation and analysis of a pulse template, adjustment of wavelet characteristic parameters, arterial elasticity evaluation and creation of the evaluation report. With the adoption of the device, the pulse signals can be collected from different positions in both sides of the subject and then analyzed and treated on real time, so as to accurately evaluate the arterial elasticity of the bilateral limbs of the subject.

An apparatus for demonstrating the beneficial effects of elastic arteries comprising an input port connected to a one-way valve, the input port having an input cross sectional area; an expandable member having an input and an output, the input of the expandable member communicatively coupled with the input port and the one-way valve for allowing fluid to flow into the expandable member, and the expandable member capable of varying in volume based on a pressure exerted at the input port; and an output port communicatively coupled with the expandable member at the output for allowing fluid to flow out of the expandable member, the output port having an output cross sectional area that is smaller then the input port cross sectional area; and a method of demonstrating the beneficial effects of elastic arteries comprising providing an arterial elasticity simulator and analogizing concepts of cardiovascular physiology with the arterial elastic simulator.

Noninvasive angioplasty using momentary vacuum therapy (MVT) is applied to treat erectile dysfunction, peripheral artery disease, and deep vein thrombosis. MVT is a noninvasive angioplasty technique which momentarily increases blood pressure to flatten arterial plaque and increase arterial elasticity for peripheral artery disease and deep vein thrombosis. The workload on the heart will be reduced by the flattening of plaque and the increase in elasticity of the peripheral arteries. The reduction in workload may be a treatment for congestive heart failure (heart failure). For treating erectile dysfunction, MVT increases the elasticity of penile arteries but does not flatten penile plaque; when treating erectile dysfunction with MVT, only an increase in arterial elasticity is required.

The invention discloses a traditional Chinese medicine composition for treating hypertension, hyperlipidemia and hyperglycemia and cardiovascular diseases and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 50 parts of nattokinase, 2 to 8 parts of sea buckthorn, 20 to 40 parts of semen ziziphi spinosae extract, 4 to 6 parts of moringa leaf, 5 to 15 parts of chlorella pyrenoidosa, 2 to 8 parts of antrodia camphorate and 4 to 6 parts of pumpkin powder. The traditional Chinese medicine composition disclosed by the invention mainly aims at symptoms including the hypertension, the hyperlipidemia, arterial elasticity and thrombus, can be used for effectively dissolving the thrombus, improving the vascular elasticity and alleviating heart load, especially has a unique curative effect on the hypertension and coronary disease and is used for improving the body functions; the traditional Chinese medicine composition is safe and reliable and is used for treating both principal and secondary aspects of diseases.

A method to measure arterial elasticity and arteriosclerosis includes a measuring step and a sampling step to obtain a pulse waveform which represents the displacement of an arterial wall during elastic dilation and contraction. The method of the invention also includes a first differentiation step and a second differentiation step to respectively obtain a first differential pulse waveform and a second differential pulse waveform. The evaluation data is obtained when the arterial wall dilates to the maximum thereof. In an evaluating step, the maximum elastic force represented by the second differentiation of the maximum displacement of the arterial wall is divided by the maximum displacement of the arterial wall to obtain an arterial elasticity coefficient to determine extent of arteriosclerosis and prevent cardiovascular diseases. The present invention has advantages of noninvasive and direct evaluation to arterial elasticity, easy operation, high accuracy and low cost and thus has very high utility.

Noninvasive angioplasty using momentary vacuum therapy (MVT) is applied to treat erectile dysfunction, peripheral artery disease, and deep vein thrombosis. MVT is a noninvasive angioplasty technique which momentarily increases blood pressure to flatten arterial plaque and increase arterial elasticity for peripheral artery disease and deep vein thrombosis. The workload on the heart will be reduced by the flattening of plaque and the increase in elasticity of the peripheral arteries. The reduction in workload may be a treatment for congestive heart failure (heart failure). For treating erectile dysfunction, MVT increases the elasticity of penile arteries but does not flatten penile plaque; when treating erectile dysfunction with MVT, only an increase in arterial elasticity is required.

The invention discloses a method for evaluating an arterial elastic function through pulse waves on basis of arm position variation. The method comprises the following steps: taking an arm of a subject as a reference arm; taking the other arm as a moving arm; synchronously measuring pulse signals of radial arteries of the two arms; recognizing collected signals by using signal analysis software; for the pulse signal at each testing position of each subject, intercepting pulse signals in set periods according to the starting point, and respectively performing normalization processing on the signals in the set periods; calculating the width of a waveform at the peak of a set percentage of the normalized pulse signals; taking the other arm of the subject as a reference arm for performing the same operation; calculating and analyzing the mean and variance of the peak width of the set percentage in two rounds of repeated experiments of each subject, and quantizing the waveform change conditions of the pulse signals in different positions of the arm, so that the arterial elastic function can be accurately evaluated according to the waveform variation.

The invention discloses a pseudo-aneurysm sealer, and belongs to the technical field of interventional medical instruments. The pseudo-aneurysm sealer comprises a sleeve, wherein the sleeve comprises an outer tube (1) and an inner tube (2); a balloon pipeline (3) is arranged between the outer tube (1) and the inner tube (2); the front end of the balloon pipeline (3) is connected with an elastic balloon (4); the outer tube (1) is provided with a plurality of side through holes (9); the pseudo-aneurysm sealer is further provided with a liquid medicine pipeline (10); the front end of the liquid medicine pipeline (10) is communicated with the side through holes (9). By adopting the pseudo-aneurysm sealer, a blood coagulation medicament can be prevented from flowing into arteries, the elastic balloon is used for compressing and sealing a pseudo-aneurysm leakage opening, and high-speed arterial blood flow from the pseudo-aneurysm leakage opening can be prevented from continually entering a tumor body, so that thrombus in the tumor body is formed more easily; meanwhile, the blood coagulation medicament is injected into the tumor body through the side through holes, so that formation of thrombus in the tumor body is further promoted, double guarantees of sealing the pseudo-aneurysm leakage opening are realized, and severe consequences can be avoided.

The invention discloses an application of N-[2-[3-(1- piperazine methyl) imidazo [2, 1-B] thiazole-6-base] phenyl]-2-quinoxaline formamide in preparation of a medicament for prevention and treatment of high blood pressure. The experiment research proves that the N-[2-[3-(1- piperazine methyl) imidazo [2, 1-B] thiazole-6-yl] phenyl]-2-quinoxaline formamide can greatly reduce the tail arterial blood pressure, central aortic systolic blood pressure, central aortic diastolic blood pressure, center average arterial pressure and pulse wave velocity of hypertension rats, can improve the artery elastic function, and can reduce the middle thickness of aorta and the vessel wall collagen fiber, increases the blood vessel diameter, and has a favorable effect of prevention and treatment of high blood pressure; and even no significant adverse reactions appear in the experiment process, the medicament is expected to be developed into a new generation safe and effective medicament for prevention and treatment of high blood pressure.

The invention discloses a medicine for treating a coronary heart disease. The medicine is mainly prepared from uncaria, a Chinese fevervine herb, himalayan teasel roots, salvia miltiorrhiza, Cherokee rose fruits, hairyvein agrimony, a herb of spanishneedles, rhizomes and roots of ocreate greenbrier, amomum villosum, pittosporum tubiflorum, hawthorn fruits, astragalus roots, gingers, gaultheria yunnanensis, a perfoliate knotweed herb, motherwort, forsythia, tuber fleeceflower stems, Chinese mahonia and radix berberidis. The medicine can improve coronary blood-flow volume and increase myocardial oxygen content, enables the myocardial oxygen demand to be increased, improves the activity of dredging coronary arterial wall, increases coronary arterial elasticity and the like, can be used for treating the coronary heart disease, is remarkable in treating effect, short in treatment period, safe and free of side effect and enables the coronary heart disease not to relapse.

The invention discloses a noninvasive artery elasticity detection method and device, and relates to the technical field of clinical detection. The device comprises a blood pressure detection unit, a blood flow detection unit and a data processing unit, the blood pressure detection unit comprises two force sensitive devices, and the blood flow detection unit comprises an ultrasonic transmitting module and an ultrasonic receiving module. When artery elastic detection is carried out, firstly, the two force sensitive elements are placed at the same pulse position at a certain interval, and pulse wave signals are obtained in real time; meanwhile, the ultrasonic transmitting module and the ultrasonic receiving module which are placed at the same pulse position obtain an ultrasonic transmitting signal and an ultrasonic echo signal reflected by blood by using a Doppler ultrasonic detection technology. Then the pulse wave signal, the ultrasonic transmitting signal and the ultrasonic echo signal are transmitted to a data processing unit, and a blood pressure value and a blood flow value are obtained after processing. And finally, calculating the arterial elasticity index through the blood pressure value and the blood flow value. The blood pressure and blood flow parameters are synchronously obtained, and the obtained arterial elasticity index is more accurate.

An apparatus for demonstrating the beneficial effects of elastic arteries comprising an input port connected to a one-way valve, the input port having an input cross sectional area; an expandable member having an input and an output, the input of the expandable member communicatively coupled with the input port and the one-way valve for allowing fluid to flow into the expandable member, and the expandable member capable of varying in volume based on a pressure exerted at the input port; and an output port communicatively coupled with the expandable member at the output for allowing fluid to flow out of the expandable member, the output port having an output cross sectional area that is smaller then the input port cross sectional area; and a method of demonstrating the beneficial effects of elastic arteries comprising providing an arterial elasticity simulator and analogizing concepts of cardiovascular physiology with the arterial elastic simulator.