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A quantized multi-rank beamforming scheme for multiple-antenna systems such as a multiple-input-multiple-output (MIMO) wireless downlink. User equipment (UE) estimates downlink channel and transmit power and determines rank and power allocations. A quantized beamforming matrix is then determined by the UE using successive beamforming. The UE also determines channel quality indices (CQI) which it feeds-back to the wireless downlink base station along with the index of the quantized beamforming matrix. The base station uses the CQI information to select a UE for scheduling of downlink transmission and the quantized beamforming matrix index received from the selected UE to beamform the downlink transmission to the UE. Base station overhead and is minimized while providing near-optimal performance given the constraints of a limited feed-back channel and computational complexity of the UE.

Apparatus and method can be provided for obtaining information regarding at least one portion of a biological structure. For example, using a first arrangement, it is possible to generate a first electro-magnetic radiation to be forwarded to the portion and receive, from the portion, a second fluorescent radiation associated with the first electro-magnetic radiation Further, using a second arrangement, it is possible to obtain information associated with the second fluorescent radiation, and generate at least one image of the portion as a function of the second fluorescent radiation. According to an exemplary embodiment of the present invention, the first arrangement can be inserted into at least one lumen, and the image of the portion may be associated with the at least one lumen.

The present invention provides a method of detecting antigens, which comprises immobilizing an antigen to a solid support and contacting the solid support with a means for hybridizing a labeled dendrimer to the antibody, through an oligonucleotide complexed thereto. A directly oligonucleotide labeled primary antibody or an oligonucleotide labeled secondary antibody may be employed, and a conventionally labeled dendrimer can subsequently be hybridized to the oligonucleotide through one or more of the outer arms of the dendrimer. The present invention offers the advantage over conventional methods of antigen detection by providing multiple label molecules per antigen, thereby enhancing the observed signal associated with the label.

This disclosure provides methods for the creation of a quantitative database of metabolites, particularly lipid metabolites, using chromatographic technology; methods for assembling that information into a visual format for interpretation, and methods of this information to identify and understand metabolome-wide effects, for instance those effects influenced by pharmaceuticals, genes, toxins, diet or the environment. Also provided are metabolite databases, such as lipid metabolite databases, that are stored on a computer readable medium, which include quantitative measurements of a plurality of metabolites.

A method for analyzing materials in an object includes acquiring x-ray projection data of the object at high energy and at low energy for a plurality of views. The acquired x-ray projection data is utilized in a material decomposition to determine material densities at each pixel for two selected basis materials. A composition of an object at each pixel is determined utilizing a determined mapping of material density regions for the two selected basis materials. An image indicative of the composition of the object is displayed utilizing the determined composition.

An instrument for measuring kinetic and kinematic variables of multijoint motor tasks comprises a linkage having four links connected at four joints, each joint having articulation about an axis, the four axes of articulation being substantially parallel, limb coupling means for coupling a limb to the linkage, the limb coupling means maintaining alignment of centers of rotation of two joints of the limb with centers of rotation of two joints of the linkage, means for providing a load to at least one of the two joints of the linkage, means for obtaining data respecting angular position of at least one of the joints of the linkage. In an alternative embodiment, the linkage has only two links. The invention also provides methods for detecting, monitoring, and / or treating neural and / or muscular problems associated with impaired movement of limbs.

The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such asp-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2]cycloaddition reactions and Staudinger modifications.

A mechanism for osteosynthesis 1 is provided that is capable of finely adjusting the amount of movement of a fractured bone, quantifying the amount of the movement and can be used both in pulling the fractured bones apart from each other and pulling the fractured bones nearer toward each other. A first mechanism for osteosynthesis 1 of the present invention comprises a plate part 2 for reducing two or more fractured bones monolithically by fixing at least both ends of the plate part 2 on the fractured bones and a sliding part 25 for moving one fractured bone along a sliding elongate hole 3 formed in the plate part 2 so as to elongate from the one fractured bone toward another fractured bone, the sliding part 25 comprising a rack 31 formed on an inner surface of the sliding elongate hole so as to extend along a sliding direction and a pin inserted in the sliding elongate hole 3, the pin 4 having a head portion 41 having a pinion for engaging with the rack 31 and a base portion 45 to be inserted into the one fractured bone, wherein the sliding part 25 moves the one fractured bone slidably along the sliding elongate hole 3 by rotating the pin 4.

Apparatus, methods, and computer readable media having computer code for calibrating chromatograms to achieve chromatographic peak shape correction, noise filtering, peak detection, retention time determination, baseline correction, and peak area integration. A method for processing a chromatogram, comprises obtaining at least one actual chromatographic peak shape function from one of an internal standard, an external standard, or an analyte represented in the chromatogram; performing chromatographic peak detection using known peak shape functions with regression analysis; reporting regression coefficients from the regression analysis as one of peak area and peak location; and constructing a calibration curve to relate peak area to known concentrations in the chromatogram. A method for constructing an extracted ion chromatogram, comprises calibrating a low resolution mass spectrometer for both mass and peak shape in profile mode; performing mass spectral peak analysis and reporting both mass locations and integrated peak areas; specifying a mass defect window of interest; summing up all detected peaks with mass defects falling within the specified mass defect window to derive summed intensities; and plotting the summed intensities against time to generate a mass defect filtered chromatogram.

A method for providing audio data corresponding to a requested musical note is disclosed, the method comprising: (a) providing a render cache having a plurality of cache entries, each of the cache entries corresponding to a different note; (b) receiving a request for a first note from a client; (c) identifying a first cache entry corresponding to the first note; (d) determining that a first audio segment corresponding to the first cache entry is not available; (e) identifying a second audio segment corresponding to a near-hit cache entry in the render cache; and (f) processing the second audio segment into a third audio segment that is substantially similar to the first audio segment.

A quantized multi-rank beamforming scheme for multiple-antenna systems such as a multiple-input-multiple-output (MIMO) wireless downlink. User equipment (UE) estimates downlink channel and transmit power and determines rank and power allocations. A quantized beamforming matrix is then determined by the UE using successive beamforming. The UE also determines channel quality indices (CQI) which it feeds-back to the wireless downlink base station along with the index of the quantized beamforming matrix. The base station uses the CQI information to select a UE for scheduling of downlink transmission and the quantized beamforming matrix index received from the selected UE to beamform the downlink transmission to the UE. Base station overhead and is minimized while providing near-optimal performance given the constraints of a limited feed-back channel and computational complexity of the UE.

Embodiments of the present invention provide the use of average CT (ACT) to match the temporal resolution of CT and PET to enhance PET imaging and evaluated tumor quantification with HCT and ACT. For example, an embodiment of a method of enhanced PET imaging on a PET / CT scanner includes generating an average CT scan responsive to 4D CT emission image data to thereby correct attenuation in PET emission image data. Another embodiment of a method of attenuation correction in a PET / CT scan includes averaging a plurality of consecutive low dose CT images of approximately one breathing cycle to thereby obtain an average CT.

An audio processing apparatus includes first and second audio pickup units. The second audio pickup unit includes an audio resistor provided to cover a sound receiving portion to suppress external wind introduction while passing an external audio. A first filter attenuates a signal having a frequency lower than a first cutoff frequency of the output signal of a first A / D converter. A second filter attenuates a signal having a frequency higher than a second cutoff frequency of the output signal of a second A / D converter. A third filter is provided between the first audio pickup unit and the first A / D converter to attenuate a signal having a frequency lower than a third cutoff frequency for suppressing the wind noise.

A prefilled syringe including a barrel having an opening at opposite ends and an inwardly projecting annular wall at a distal end and a plastic film tube hermetically bonded to a needle-connecting member and the plunger at each end.

An apparatus and method for adaptively adjusting a target Received Signal Strength Indicator (RSSI) for Automatic Gain Control (AGC) in a full-duplex relay apparatus with an interference cancellation function. A Signal to Interference Ratio (SIR) estimation block estimates an SIR based on an interference signal estimated from a received signal and an interference-cancelled signal determined by cancelling the estimated interference signal from the received signal. A target RSSI determination block determines a target RSSI according to the estimated SIR. An AGC block adjusts a gain for the received signal based on the determined target RSSI.

The present invention is a single self-contained device for collecting, transferring, extracting, and testing for the presence of a target analyte in a sample obtained from a surface by swabbing, solid materials (pills, capsules, unknown powders), air samples and biological and non-biological fluids. The device includes a swab, a retention well including eluent fluid, and analysis technologies which can include but are not limited to lateral flow testing analysis. The major improvement is the invention of rinsing the swab with proprietary elution fluid prior to testing thereby not compromising the chemistry and allowing for a wide variety of applications under extremely hot or cold field conditions. Also, the device is in one self-contained unit instead of having a separate water dropper or spray. Moreover, the shape of the device is similar to a magic marker so it is more substantial than any drug tester on the market, as well in certain embodiments it can have grips resembling a gun and in certain embodiments can even emit sounds or smells when a surface is wiped or a positive test is attained

Methods and instruments for assessing bone, for example fracture risk, in a subject in which a test probe is inserted through the skin of the subject so that the test probe contacts the subject's bone and the resistance of the test bone to microscopic fracture by the test probe is determined. Macroscopic bone fracture risk is assessed by measuring the resistance of the bone to microscopic fractures caused by the test probe. The microscopic fractures are so small that they pose negligible health risks. The instrument may also be useful in characterizing other materials, especially if it is necessary to penetrate a layer to get to the material to be characterized.

An encoder, a decoder, and corresponding methods are provided for encoding and decoding video signal data for an image block. The encoder includes a quantizer for receiving transform coefficients for the image block, and for adaptively performing dead-zone quantization based on coefficient positions and coefficient distributions of the transform coefficients.

An amplifier and a driver circuit therefor are presented for driving a load according to a system analog input. The amplifier comprises a passive delta-sigma modulator with a passive filter providing a first filtered signal according to a passive filter input and according to a feedback signal, a quantizer coupled with the passive filter and providing a quantized output according to the first filtered signal, and a switching system coupled with the the passive filter and the quantizer. The switching system selectively providing power to a load according to the quantized output and provides the feedback signal to the passive input, wherein a gain amplifier is provided in a feedback loop around the passive delta-sigma modulator.

Described herein are approaches to the detection and quantitation of short RNAs in a biological sample. The methods permit the detection and quantitation of individual species of short RNA in a nucleic acid sample, both singly and in a multiplex format that permits the determination of expression levels for two or more target short RNAs in a single reaction.

An ion detection arrangement 140 for a time-of-flight (TOF) mass spectrometer 10 includes a beam splitter formed as a mesh 150 at the end of the TOF acceleration and detection chamber 110. Ions enter the detection arrangement through a common entrance window and are then divided by the beam splitter. Those ions striking the mesh 150 generate secondary electrons 160 which are detected by a microchannel plate forming a first detector 170. Those ions passing through the ion beam splitter are detected directly by a second detector 190 also formed from a microchannel plate.The two detectors are each connected to a corresponding data acquisition system 180, 200 and the data obtained by each are combined to generate a mass spectrum. The problems of detector saturation are thus avoided.

A stereo camera supporting apparatus of the present invention comprises a joining member constituted in such a manner as to support a stereo camera on a vehicle, and a control device which controls posture or position of the stereo camera supported on the vehicle by the joining member. The control device controls the posture or position of the stereo camera with respect to video obtained by the stereo camera in such a manner that a contour portion present in the highest level position in a contour of a noted subject in the video is positioned in a frame upper end of the video or its vicinity irrespective of a change of the posture or position of the vehicle.

A dual source system and method includes a high power laser used to determine elements in a sample and a lower power device used to determine compounds present in the sample. An optical subsystem directs photons from a sample to a detector subsystem after laser energy from the laser strikes the sample along an optical path. After energy from the device strikes the sample protons are directed to the detector subsystem along the same optical path. The detector subsystem receives photons after laser energy from the laser strikes the sample and provides a first signal, and receives photons after energy from the device strikes the sample and provides a second signal. A controller subsystem pulses the high power laser and processes the first signal to determine elements present in the sample, energizes the lower power device and processes the second signal to determine compounds present in the sample.

A block dead zone scale generator (202) receives an image signal and a prediction error, analyzes the pattern or prediction performance of a target block, and outputs a dead zone scale suitable for the pattern or prediction performance of the block. A dead zone generator (201) receives a dead zone scale from the block dead zone scale generator (202) and an MB quantization parameter from a quantization control device (103), calculates a dead zone width from the zone scale and the MB quantization parameter, and outputs the dead zone width. A quantization device (102) quantizes an orthogonal transformation coefficient supplied from an orthogonal transformation device (101) by using a dead zone from the dead zone generator (201), and outputs a quantized transformation coefficient. This makes it possible to realize quantization with arbitrary strength for each transformation coefficient and for each block comprising a plurality of transformation coefficients as constituent elements, thereby providing a high-quality image encoding technology.