The invention discloses a multi-network refined emergency rescue command system based on cloud computing, and the system comprises an emergency rescue command system and application networks. The emergency rescue command system comprises a rear commanding center, a front commanding center, and an onsite rescue team. The application networks comprise an air and space emergency transmission network,an onsite emergency communication network, a self-organizing wireless transmission network and an early warning information issuing network. The system completes the conventional emergency command architecture and working mode, expands the sky-ground integrated wide coverage to the deep coverage, achieves the refined command communication of different architecture layers: the rear commanding center, the front commanding center and the onsite rescue team, can guarantee that the problems of communication interruption and paralysis caused by the great decreasing of the communication capability caused by the damages to a base station are solved in the maximum range after a major disaster, guarantees the refined command in the onsite rescue process, and greatly improves the emergency communication guarantee capability.