The invention discloses a multi-parameter sensor based on a photonic crystal fiber. An input end and an output end of the sensor are respectively provided with an input coupler and an output coupler, an annular photonic crystal fiber cavity is formed in the way that a section of hollow photonic crystal fiber is connected between the two couplers, and the section of hollow photonic crystal fiber is used as a sensing head of the multi-parameter sensor. The invention also discloses a multi-parameter measurement system which comprises a signal acquiring, processing and displaying module and the multi-parameter sensor, the sensor is respectively connected with a light source and a photoelectric detector through the input coupler and the output coupler thereof, and the photoelectric detector is connected to the signal acquiring, processing and displaying module. The invention additionally provides a pressure measurement system comprising the multi-parameter measurement system and a pressurizing device arranged on the sensing head, and the pressuring device comprises a plenum chamber, a photonic crystal fiber clamp, a connector and the like. The multi-parameter sensor and measurement system of the invention has the advantages of simple and convenient operation, simplified structure, high measurement precision, easy miniaturization and standardization design and the like.