41results about How to "Maximizes content" patented technology

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.

A control system using a genetic analyzer based on discrete constraints is described. In one embodiment, a genetic algorithm with step-coded chromosomes is used to develop a teaching signal that provides good control qualities for a controller with discrete constraints, such as, for example, a step-constrained controller. In one embodiment, the control system uses a fitness (performance) function that is based on the physical laws of minimum entropy. In one embodiment, the genetic analyzer is used in an off-line mode to develop a teaching signal for a fuzzy logic classifier system that develops a knowledge base. The teaching signal can be approximated online by a fuzzy controller that operates using knowledge from the knowledge base. The control system can be used to control complex plants described by nonlinear, unstable, dissipative models. In one embodiment, the step-constrained control system is configured to control stepping motors.

A Soft Computing (SC) optimizer for designing a Knowledge Base (KB) to be used in a control system for controlling a suspension system is described. The SC optimizer includes a fuzzy inference engine based on a Fuzzy Neural Network (FNN). The SC Optimizer provides Fuzzy Inference System (FIS) structure selection, FIS structure optimization method selection, and teaching signal selection and generation. The user selects a fuzzy model, including one or more of: the number of input and/or output variables; the type of fuzzy inference model (e.g., Mamdani, Sugeno, Tsukamoto, etc.); and the preliminary type of membership functions. A Genetic Algorithm (GA) is used to optimize linguistic variable parameters and the input-output training patterns. A GA is also used to optimize the rule base, using the fuzzy model, optimal linguistic variable parameters, and a teaching signal. The GA produces a near-optimal FNN. The near-optimal FNN can be improved using classical derivative-based optimization procedures. The FIS structure found by the GA is optimized with a fitness function based on a response of the actual suspension system model of the controlled suspension system. The SC optimizer produces a robust KB that is typically smaller that the KB produced by prior art methods.

An instrument (1) and a method for measuring pulses of partial electrical discharges in an electrical system comprise data processing means (5) operatively associated both with an input stage (2), able to receive an analogue signal (3) representing said pulses and to provide a digital representation of the entire wave form of the pulses, to receive said digital representation, extract the value of predetermined parameters relating to the wave form of the pulses and transfer to and output stage (4) a processed digital signal comprising said values, the processing means (5) being able to operate substantially in real time, i.e. with no need for a memory for the intermediate storage of the data. Known solutions within the field of the measurement of partial discharge pulses for diagnostic purposes provide for the use of peak detector instruments, which are not able to measure all information useful for a diagnosis of the electrical system, and oscilloscopes interacting with a computer, disadvantageous in terms of costs and of calculation efficiency.

This invention is directed to treating disease states or conditions associated with the treatment and prevention of neurodegeneration and neurodegenerative disease states, and treatment of radiation damage. The invention relates to novel phytonutrient compositions and compounds comprising L-ergothioneine and/or selenium. The invention also provides a method of administering these compositions and combinations to humans or animals in need thereof.

In accordance with the present invention, a high intensity radiopaque contrast agent is disclosed. The agent may be coated on or incorporated within bulk material which may then be subsequently utilized to fabricate a radiopaque medical device. Primary effects through chemistry include higher radiopaque concentrations per unit weight of the radiopaque element or agent. Secondary effects include selective placement of the radiopaque elements which may further enhance the radiopacity of the device with reduced requirements of the radiopaque agent. Such a radiopaque contrast agent may be produced in various forms such as a dendrimer and/or incorporated as the end groups of polymeric chain. In addition one can incorporate biological and/or pharmaceutical agents in combination with the present invention.

Provided is a pneumatic tire comprising a tread section, a side wall section, and a bead section. A tire constituent member is provided in at least the tread section, extending along the tire circumferential direction and spliced at any positions in the tire circumferential direction. A belt-shaped sound-absorbing member is adhered to a region corresponding to the tread section in the tire inner surface, along the tire circumferential direction and via an adhesive layer. The sound-absorbing member is arranged intermittently along the tire circumferential direction. Sections where the sound-absorbing member is missing are arranged at positions corresponding to the splice portions of the tire constituent member and the sound-absorbing member is arranged so as to not overlap the splice portions.

In a computer-based graphics imaging system, binocular tone mapping is employed with an optimization-based framework to generate a binocular single vision image with more visual richness than a single tone-mapped image, the binocular tone mapping being guided by a binocular viewing comfort predictor (BVCP) metric in order to assure stable formation of binocularly tone-mapped image pairs, so that visual information content of the image pair can be maximized without triggering visual discomfort.

Disclosed is a multi-functional bio polyurethane foam and a method for manufacturing the same. More particularly, disclosed is a multi-functional bio polyurethane foam containing a reaction product of a resin premix and a pre-polymer, in which the resin premix includes from about 5% by weight to about 30% by weight of a biopolyol. The multi-functional bio polyurethane foam has a maximized content of a biopolyol while exhibiting physical properties which are equivalent to those of a petroleum-based polyol-based polyurethane foam in the related art, and further provides a strengthened antibacterial function and minimized vibration transmissivity.

The present invention relates to a manufacturing method of medical sterilized normal saline, more specifically, to such a method for manufacturing sterilized normal saline for medical purpose with effective sterilizing efficacy comprising: a step of disposing at least one electrode set immersed in saline solution of pH 4.0 to pH 7.5 including a pair of electrodes with flat surface separated from each other by an interval between 1 mm and 3 mm, the flat surfaces of the electrodes facing each other; and a step of supplying 3 OmA to 20 OmA direct current to the electrodes by applying 2.4V to 3.3V DC power to the electrodes; wherein free chlorine is reliably and stably generated as having concentration range between 0.17 ppm and 6 ppm from electrolysis between electrodes.