40results about How to "Limit transport" patented technology

The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

The present invention includes an intra-bronchial device, system, and method for providing a therapeutic agent to a patient. A device includes a flow control member for placement in an air passageway communicating with a lung portion, and when deployed in the air passageway inhibits a therapeutic agent distal of the control member from moving proximal of the control member, and includes the therapeutic agent associated with the flow control member. The control member may inhibit movement of the therapeutic agent by limiting airflow, and may include a one-way valve limiting exhalation of air from the lung portion. The control member may include a flexible membrane impervious to air flow, or a separator arranged to inhibit the movement of the therapeutic agent. The control member may include at least one anchor, and the anchor may be releasable from the air passageway for removal of the intra-bronchial device.

Solid-state membrane modules comprising at least one membrane unit, where the membrane unit has a dense mixed conducting oxide layer, and at least one conduit or manifold wherein the conduit or manifold comprises a dense layer and at least one of a porous layer and a slotted layer contiguous with the dense layer. The solid-state membrane modules may be used to carry out a variety of processes including the separating of any ionizable component from a feedstream wherein such ionizable component is capable of being transported through a dense mixed conducting oxide layer of the membrane units making up the membrane modules. For ease of construction, the membrane units may be planar.

A molecular-based switching device and method for controlling charge transport across a molecule. The molecular-based switching device includes a molecule having first and second nodes in between which destructive quantum interference restricts electrical conduction from the first node to the second node in an off-state, a first electrode connected to the first node and configured to supply charge carriers to the first node, a second electrode connected to the second node and configured to remove the charge carriers from the second node, and a control element configured to reduce coherence in or alter charge transport paths between the first and second nodes so as to reduce existing destructive quantum interference and permit flow of the charge carriers from the first node to the second node. The method applies an electric potential between the first and second electrodes, controls coherence in charge transport paths between the first and second nodes so as to maintain or reduce destructive interference between the first and second nodes of the molecule, and injects charge carriers from the first electrode into the first node and collects the charge carriers from the second node at the second electrode when the coherence is controlled to reduce destructive interference.

A transporting device which transports a belt-shaped base material by considering a longitudinal direction of the base material as a transporting direction, includes a first driving roller which transports the base material in the transporting direction; a second driving roller which is disposed to be closer to a downstream side of the transporting direction than the first driving roller, and transports the base material in the transporting direction; an inter-roller transporting path which is provided between the first driving roller and the second driving roller, and through which the base material is transported in a state where the base material is suspended in a direction of gravity and bent; and a tension applying portion which suctions a bent part of the base material from a lower side in the direction of gravity, and applies tension to the base material on the inter-roller transporting path.

To provide a sheet transporting device which can control sheet transport also with respect to plural kinds of tab sheets different from each other in terms of a tab position in a vertical direction with respect to a transporting direction without increasing the cost. In case of switching back the tab sheet, a timing for the switch back is controlled in accordance with a timing at which the sheet sensor detects a front end of the tab sheet.

A method to control thermal energy transport uses mobile coherent interfaces in nanoscale ferroelectric films to scatter phonons. The thermal conductivity can be actively tuned, simply by applying an electrical potential across the ferroelectric material and thereby altering the density of these coherent boundaries to directly impact thermal transport at room temperature and above. The invention eliminates the necessity of using moving components or poor efficiency methods to control heat transfer, enabling a means of thermal energy control at the micro- and nano-scales.

A transporting device which transports a belt-shaped base material by considering a longitudinal direction of the base material as a transporting direction, includes a first driving roller which transports the base material in the transporting direction; a second driving roller which is disposed to be closer to a downstream side of the transporting direction than the first driving roller, and transports the base material in the transporting direction; an inter-roller transporting path which is provided between the first driving roller and the second driving roller, and through which the base material is transported in a state where the base material is suspended in a direction of gravity and bent; and a tension applying portion which suctions a bent part of the base material from a lower side in the direction of gravity, and applies tension to the base material on the inter-roller transporting path.