132results about How to "Less effective" patented technology

A gripper assembly for anchoring a tractor within a downhole passage and for assisting movement of the tractor within the passage. The gripper assembly includes an elongated mandrel and flexible toes that can be radially displaced to grip onto the surface of the passage. The toes are displaced by the interaction of a driver slidable on the mandrel and a driver interaction element on the toes. In one embodiment, the toes are displaced by the interaction of rollers and ramps that are longitudinally movable with respect to one another. In another embodiment, the toes are displaced by the interaction of toggles that rotate with respect to the toes.

A conformable paste comprising porous agglomerates of carbon black dispersed in a paste-forming vehicle is disclosed. The paste is useful as an interface material for improving the thermal contact between two proximate solid surfaces, such as the surfaces of a heat source and a heat sink. Upon compression between the two solid surfaces, the paste forms a material that enhances the thermal contact between said surfaces. This invention also discloses a conformable interface material which, upon compression between two proximate solid surfaces, forms a material that enhances the thermal contact between said surfaces. This interface material comprises (i) a sheet and (ii) a conformable, spreadable and thermally conductive paste on each of the two opposite sides of the sheet, said paste comprising porous agglomerates of carbon black dispersed in a paste-forming vehicle. In addition, a method of providing a thermal contact between two solid surfaces is disclosed. This method comprises disposing between and in contact with said surfaces a material comprising: a conformable, spreadable and thermally conductive paste comprising porous agglomerates of carbon black dispersed in a paste-forming vehicle, and applying a pressure to cause said material to conform to the topography of said surfaces.

Improved molecular vaccines comprise nucleic acid vectors that encode a fusion polypeptide that includes polypeptide or peptide physically linked to an antigen. The linked polypeptide is one that (a) promotes processing of the expressed fusion polypeptide via the MHC class I pathway and / or (b) promotes development or activity of antigen presenting cells, primarily dendritic cells. These vaccines employ one of several types of nucleic acid vectors, each with its own relative advantages: naked DNA plasmids, self-replicating RNA replicons and suicidal DNA-based on viral RNA replicons. Administration of such a vaccine results in enhance immune responses, primarily those mediated by CD8+ cytotoxic T lymphocytes, directed against the immunizing antigen part of the fusion polypeptide. Such vaccines are useful against tumor antigens, viral antigens and antigens of other pathogenic microorganisms and can be used in the prevention or treatment of diseases that include cancer and infections.

A conformable paste comprising porous agglomerates of carbon black dispersed in a paste-forming vehicle is disclosed. The paste is useful as an interface material for improving the thermal contact between two proximate solid surfaces, such as the surfaces of a heat source and a heat sink. Upon compression between the two solid surfaces, the paste forms a material that enhances the thermal contact between said surfaces. This invention also discloses a conformable interface material which, upon compression between two proximate solid surfaces, forms a material that enhances the thermal contact between said surfaces. This interface material comprises (i) a sheet and (ii) a conformable, spreadable and thermally conductive paste on each of the two opposite sides of the sheet, said paste comprising porous agglomerates of carbon black dispersed in a paste-forming vehicle. In addition, a method of providing a thermal contact between two solid surfaces is disclosed. This method comprises disposing between and in contact with said surfaces a material comprising: a conformable, spreadable and thermally conductive paste comprising porous agglomerates of carbon black dispersed in a paste-forming vehicle, and applying a pressure to cause said material to conform to the topography of said surfaces.

An intravascular catheter for nerve activity ablation and / or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

A multi-chamber container (60) includes a first chamber (2) having a side wall (3) terminating at a first chamber upper end (5). A first chamber opening (6) is disposed in the first chamber upper end (5). The first chamber side wall (3) is formed from an inner circumference portion (62) and an outer circumference portion (63). The multi-chamber container (60) includes a second chamber (10) having a side wall (11) terminating at a second chamber side wall upper end (13) which has a second chamber opening (14). A hinge (61) is disposed intermediate each chamber inner and outer side wall interface portion (66). The chambers (2) and (10) are moveable about the hinge (61) between a first position where the inner circumference side wall portions (62) and (64) are spaced apart, and a second position where the inner circumference side wall portions (62) and (64) of the chambers are adjacent.