The invention relates to the field of blood oxygen probes, in particular to a high-comfort blood oxygen probe structure with adjustable clamping force. The structure comprises a mounting block, arc-shaped connecting plates are fixedly mounted on the upper side face and the lower side face of the mounting block through first hinge pieces, and the inner walls of the arc-shaped connecting plates arein transmission connection with the mounting block through adjusting mechanisms. Connecting mechanisms are arranged on the right side faces of the arc-shaped connecting plates correspondingly, an upper clamping assembly and a lower clamping assembly are fixedly installed on the right side faces of the upper connecting mechanism and the lower connecting mechanism correspondingly, and light emittingdiodes are arranged on the opposite side faces, close to the middle, of the upper clamping assembly and the lower clamping assembly correspondingly. The clamping force can be adjusted conveniently, meanwhile, the softness and friction force are increased through the skin-friendly silica gel pad and the small protruding particles, clamping is more comfortable, falling is not likely to happen, theskin-friendly silica gel pad can be replaced conveniently, use is more sanitary, the clamping length can be adjusted, the requirement of different people for use can be met, the adapter is not likelyto fall off, and connection is firm.