54results about How to "Avoid nerve damage" patented technology

Neurophysiological instruments and techniques are improved through various enhancements. Stimulation of an instrument is possible while it is advancing into the spine or elsewhere, alerting the surgeon to the first sign the instrument or device (screw) may be too near a nerve. A directional probe helps surgeons determine the location of the hole in the pedicle. Electrically insulating sleeves prevent shunting into the soft tissues. According to a different improvement, the same probe to be used to stimulate different devices, such as screws and wires. Electrical impulses may be recorded from non-muscle regions of the body, including the spine and other portions of the central nervous system as opposed to just the extremities.

The subject invention provides methods of treating a subject afflicted with Parkinson's disease, memory disorder, depression, hyperactive syndrome, Attention Deficit Disorder, dementia, brain ischemia, stroke, head trauma injury, spinal trauma injury, neurotrauma, neurodegenerative disease, neurotoxic injury, multiple sclerosis, nerve damage, affective illness, schizophrenia or symptoms of withdrawal from an addictive substance, using the mesylate salt of R(+)-N-propargyl-1-aminoindan.

The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an effective illness, a neurodegenerative disease, a neurotoxic injury, stroke, brain ischemia, a head trauma injury, a spinal trauma injury, neurotrauma, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.

The invention provides a preparation method of an oxidized regenerated cellulose hemostatic material with a micro-nano composite structure and relates to a preparation method of an oxidized regenerated cellulose hemostatic material. The invention aims to solve the problems of low hemostatic speed, great effect on environment and uneasiness in decomposition of the existing hemostatic material. The preparation method comprises the following steps: firstly, preparing cellulose solution; secondly, netting fibers in a wet state and reinforcing into a nano layer cellulose non-woven fabric; thirdly, preparing an oxidized nano cellulose non-woven fabric and oxidized viscose staple fibers; and fourthly, cotton-slitting and cotton-carding the oxidized viscose staple fibers prepared in the step 3 and compounding to obtain the oxidized regenerated cellulose hemostatic material with the micro-nano composite structure. The preparation method is applied to the preparation field of the oxidized regenerated cellulose hemostatic material.

Macrocyclic derivative compounds that inhibit protein kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and / or disturbed kinase activity such as cancers, psoriasis, viral and bacterial infections, inflammatory and autoimmune diseases.

Neurophysiological instruments and techniques are improved through various enhancements. Stimulation of an instrument is possible while it is advancing into the spine or elsewhere, alerting the surgeon to the first sign the instrument or device (screw) may be too near a nerve. A directional probe helps surgeons determine the location of the hole in the pedicle. Electrically insulating sleeves prevent shunting into the soft tissues. According to a different improvement, the same probe to be used to stimulate different devices, such as screws and wires. Electrical impulses may be recorded from non-muscle regions of the body, including the spine and other portions of the central nervous system as opposed to just the extremities.

The invention relates to an artificial temporal-mandibular joint replacement prosthesis. The replacement prosthesis comprises a glenoid fossa prosthesis and a mandible ramus prosthesis; the glenoid fossa prosthesis is made of supra polymer polyethylene polymer and comprises a tissue surface in contact with the glenoid fossa and a function surface in contact with the mandible ramus prosthesis, the tissue surface comprises a wing plate which is in contact with the zygomatic arch and is fixed to the zygomatic arch and a protrusion part in contact with the glenoid fossa, and the function surface comprises a sunken part in contact with the mandible ramus prosthesis and stopping plates arranged at the two ends of the sunken part; and the mandible ramus prosthesis comprises a condyloid process head and a mandible ramus fixing handle, the condyloid process head is cylindral and is in contact with the sunken part, the mandible ramus fixing handle is attached to the outer lateral face of the mandible ramus. By means of the artificial temporal-mandibular joint replacement prosthesis, the standard form artificial joint prosthesis is more suitable for the dissection appearance of the Chinese and is better attached to the jaw, complications in and after an operation are effectively reduced, the using effect of the standard form artificial joint prosthesis is improved, and the service life of the standard form artificial joint prosthesis is prolonged.

An optical nerve stimulation system for optically stimulating and locating a nerve, includes: a laser radiation source positioned adjacent to the nerve and configured to deliver laser radiation to the nerve through one or more optical fibers, thereby heating it; wherein the laser radiation source is operated in a continuous-wave mode; and a temperature sensor positioned adjacent to the nerve and a feedback loop configured to control the laser radiation source such that a predetermined temperature is maintained. The laser radiation source is one or more of an infrared laser and a near-infrared laser. Optionally, the laser radiation has a wavelength of between 1400 and 1900 nm. The one or more optical fibers are one or more single-mode fibers. The ONS probe includes one or more SMFs with chemically-etched tips and lenses for providing collimation and / or beam shaping to provide a flat-top spatial beam profile.

This invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for preventing neurological damage associated with glucocorticoid therapy in ventilator-dependent low birth weight preterm infants. Mifepristone, a potent glucocorticoid receptor antagonist, can be used in these methods.

The invention relates to the field of medical instruments, in particular to a sacroiliac joint through-screw positioning coaxial guide and an assembly thereof. The sacroiliac joint through-screw positioning coaxial guide comprises a first positioning rod for fixing a first puncture sleeve, a second positioning rod for fixing a second puncture sleeve, an adjusting device for adjusting a relative distance between the first positioning rod and the second positioning rod, and a fixing device for fixing the positions of the first positioning rod and the second positioning rod. The first positioningrod and the second positioning rod are respectively connected with the adjusting device, and the first positioning rod and the second positioning rod are axially symmetric by taking a vertical centerline of the adjusting device as an axis of symmetry, such that a horizontal centerline of the first puncture sleeve and a horizontal centerline of the second puncture sleeve are in the same line. Thefixing device is connected with the adjusting device. A sacroiliac joint screw can penetrate through a sacroiliac joint and can be accurately placed into the patient body, so that the surgical positioning is accurate, the stability is high, the safety is high, and complications such as vascular nerve injury are avoided.

Provided are a medical insertion apparatus includes a screw body to be inserted into a body, and an electrode provided in the screw body and including an externally exposed portion, wherein a through-hole may be provided in the screw body or the electrode, and a medical insertion apparatus includes a screw body to be inserted into a body, and an electrode provided in the screw body and exposed to an outside of the screw body, wherein the screw body and the electrode may be provided in a connectable or separable structure.

The invention provides new methods for treating certain disorders resulting from neurodegeneration and for treating depression which comprise administration of NR2B subunit selective NMDA antagonists. The disorders that can be treating by the invention include hearing loss, vision loss, neurodegeneration caused by epileptic seizures, neurotoxin poisoning, Restless Leg Syndrome, multi-system atrophy, non-vascular headache, and depression.

According to one embodiment, a medical insertion apparatus includes a screw nail body inserted into a human body and an electrode which is provided in the screw nail body and includes an externally exposed portion. Here, a through hole may be formed in the screw nail body or the electrode. According to one embodiment, a medical insertion apparatus includes a screw nail body inserted into a human body and an electrode which is provided in the screw nail body and exposed outside the screw nail body. Here, the screw nail body and the electrode may be provided as a combinable or separable structure. According to one embodiment, a medical insertion apparatus includes a screw nail body inserted into a human body, a driver engaged with the screw nail body to tighten or loosen the screw nail body, and a conductor portion which may be provided in the screw nail body or the driver and may include an externally exposed portion.

The invention discloses a leg fixator with an adjusting function for orthopedic patients, comprising a base, a thigh fixture and a shank fixture. One end of the base is rotationally connected with oneend of a thigh fixing plate, and the other end of the thigh fixing plate is rotationally connected with the shank fixture; the end of the shank fixture far away from the thigh fixture is symmetrically provided with two foot positioning devices; each foot positioning device includes a support rod vertically arranged, a first threaded rod is horizontally arranged at the upper end of the support rod, one end of the first threaded rod is provided with a first retaining plate that limits the two sides of the foot, the other end of the first threaded rod sleeves the support rod, the threaded rod isprovided with an extension terrace that is horizontally sleeved with a second threaded rod, and one end of the second threaded rod is provided with a second retaining plate that limits the sole. Theleg fixator is simple in structure and low in cost, allows a patient's legs to be quickly and accurately fixed to avoid side-to-side shaking of the legs, and is convenient to operate so that workloadis greatly reduced for medical staff and working efficiency is improved.

The invention provides new methods for treating certain disorders resulting from neurodegeneration and for treating depression which comprise administration of NR2B subunit selective NMDA antagonists. The disorders that can be treating by the invention include hearing loss, vision loss, neurodegeneration caused by epileptic seizures, neurotoxin poisoning, Restless Leg Syndrome, multi-system atrophy, non-vascular headache, and depression.

The invention discloses a needle knife. The needle knife comprises a needle handle and a first needle body. The needle handle is provided with a movable device; one end of the first needle body is fixed to the movable device, and the other end of the first needle body is provided with a needle edge or a dull edge; a second needle and the first needle are arrange side by side in the length direction; the second needle body is fixed to the movable device, and the other end of the second needle body is provided with a cutting sharp edge; the second needle body or the first needle body is driven by the movable device so that the second needle body and the first needle body can move relative to each other, and a first work station and a second work station are formed respectively; when the needle knife is located on the first work station, the needle edge or the dull edge goes beyond the cutting sharp edge so that the needle edge or the dull edge can work and the cutting sharp edge cannot work; when the needle knife is located on the second work station, the cutting sharp edge goes beyond the needle edge or the dull edge so that the cutting sharp edge can work and the needle edge or the dull edge cannot work. The combined needle knife can provide the function of free switching between the dull edge and the cutting sharp edge, and all parts of the needle knife are allowed to move in a retractable mode so as to provide quick selective operation of sharp, dull and special functions of the needle knife for a doctor.

The invention relates to an instant adhesive tissue patch and a preparation method thereof, and belongs to the technical field of medical materials. The instant adhesive tissue patch comprises a meshsubstrate, the mesh substrate is coated with a fibrinogen complex layer and a prothrombin layer, and the fibrinogen complex layer and the prothrombin layer are frozen at an ultralow temperature. The instant adhesive tissue patch can be rapidly attached to tissue without suture lines or drawing pins, so that nerve injury caused by fixation can be avoided and operation time is greatly saved; the patch is directly placed at an operation defect part in use, and thrombin and fibrinogen are crosslinked in a body fluid wet environment to quickly form fibrin glue for fixing the patch to the tissue; and the effects of rapid hemostasis and wound healing can be achieved at the same time.

A new method employing a known compound, bupropion hydrochloride (.±.)-1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride, and its analogues, in a new use for the treatment of TNF-related disorders is described.

A three-dimensional fracture fixation device is provided for treating clavicle fracture with the intent to protect the supraclavicular nerve from later iatrogenic transsection injury that may occur when the fixation bone plate is removed. The essential components of the three-dimensional fracture fixation device include at least one fixation locking plate, a nerve protection scutum (shield), junctional hooks connecting the fixation locking plate and supporting the nerve protection scutum (shield), and bone screws, which are assembled to form a defined space to accommodate the supraclavicular nerve during open reduction and internal fixation.

Provided are a medical insertion apparatus including a screw body to be inserted into a body, and a conductive portion provided in the screw body and including an externally exposed portion, wherein the conductive portion may extend in a longitudinal direction of the screw body and form a single closed loop, and a medical insertion apparatus including a screw body to be inserted into a body, a driver to engage with the screw body to be used to fasten or loosen the screw body, and a conductive portion provided in the screw body and the driver and including an externally exposed portion on one side of the screw body, wherein a portion of the conductive portion disposed in the screw body and another portion of the conductive portion disposed in the driver may be electrically connected to each other.

The invention relates to the technical field of tissue engineering, in particular to a Schwarm progenitor cell derived from a marrow neural crest cell and application of the Schwarm progenitor cell to promotion of nerve regeneration. The rat marrow-derived neural crest cell N1, namely, BM-NCC clone N1, is provided, the preservation number is CCTCC NO:C201647, and the rat marrow-derived neural crest cell N1 has the performance of the Schwarm progenitor cell (SCP). The invention further provides a subculture method of the BM-NCC clone N1 and a method for induced directional differentiation to the Schwarm cell (SC). The BM-NCC clone N1 is expected to be applied to nerve regeneration promotion therapy based on cells.

This invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for preventing neurological damage associated with glucocorticoid therapy in ventilator-dependent low birth weight preterm infants. Mifepristone, a potent glucocorticoid receptor antagonist, can be used in these methods.

The invention discloses a surgical lateral-position peripheral nerve and skin injury protection device, which comprises a bed body and a leg pneumatic cushion. A signal transceiving device is clampedat one end of the bed body. The device is reasonable in design and convenient to use; by arrangement of the leg pneumatic cushion and hand pneumatic cushions, a patient with hands on the hand pneumatic cushions and legs on the leg pneumatic cushion can conveniently lie on side after surgical completion; by pneumatic massage for simulating hand massage, workload of operating room nurses is reduced,and an optimal nerve injury prevention effect is achieved; by arrangement of the signal transceiving device, a control chip and a heater, remote control with mobile phone APP can be realized conveniently through the signal transceiving device, convenience and quickness in use are achieved, manual adjustment is avoided, the heater is capable of conveniently heating the leg pneumatic cushion and the hand pneumatic cushion, and convenience in constant-temperature massage is achieved. The surgical lateral-position peripheral nerve and skin injury protection device is simple, convenient and suitable for extensive popularization.

The invention discloses a lumbar endoscopic fusion technology assisted by electromagnetic navigation, and particularly relates to the technical field of lumbar minimally invasive surgeries. The technology comprises the following specific steps: 1 carrying out image matching; 2 registering an open-circuit cone; 3 registering a puncture needle, a guide rod and a working channel; 4 registering a trephine; and 5 registering an instrument under the microscope. The steps 1 to 5 are combined with an electromagnetic navigation technology, visualization of the whole surgery process is achieved, surgical instruments are continuously tracked, intraoperative fluoroscopy is avoided, the surgery time is shortened, intraoperative radiation of patients and medical staff is reduced, an operation path is planned before operation, the angle and the position of the instruments can be adjusted in time according to a holographic image presented by the electromagnetic navigation system during the surgery, so that the precision of the surgery is realized, repeated adjustment of a pipeline, excessive traction of muscles and unnecessary excision of a bony structure are avoided, nerve injury is avoided, and the surgery effect is ensured.

The invention discloses a novel method for a drug loading system constructed by means of sensitization blood platelets for treating immune thrombocytopenia. The method comprises the steps that firstly, whole blood is anti-coagulated and centrifuged to obtain platelet rich plasma, then, deep centrifuging washing is performed to obtain washed platelets, the washed platelets react with CD41 monoclonal antibody oscillation, and centrifuging is performed to obtain the CD41 monoclonal antibody modified target macrophage sensitization blood platelets; then, the sensitization blood platelets and an immunosuppressor or a chemically modified cytotoxic drugs are mixed and incubated, centrifuging and purifying are performed, and finally the sensitization blood platelet drug loading system carrying drug for resisting immune thrombocytopenia is obtained. The drug loading system has the advantages of being abundant in source, high in drug loading rate, good in biocompatibility, high in targeting, long in cycle time and the like, the drug can precisely target macrophage, and the concentration of the drug inside the macrophage is increased, so that the drug curative effect is improved, and meanwhile the toxic and side effect on normal tissue is effectively relieved.

The invention relates to the technical field of tissue engineering, in particular to a Schwarm progenitor cell derived from a marrow neural crest cell and application of the Schwarm progenitor cell to promotion of nerve regeneration. The rat marrow-derived neural crest cell N1, namely, BM-NCC clone N1, is provided, the preservation number is CCTCC NO:C201647, and the rat marrow-derived neural crest cell N1 has the performance of the Schwarm progenitor cell (SCP). The invention further provides a subculture method of the BM-NCC clone N1 and a method for induced directional differentiation to the Schwarm cell (SC). The BM-NCC clone N1 is expected to be applied to nerve regeneration promotion therapy based on cells.

The invention provides a nerve block anesthesia medicine injection pressure measurement alarm device under ultrasound, and relates to the field of medical equipment. The nerve block anesthesia medicine injection pressure measurement alarm device under ultrasound comprises an injection device, a three-way pipe is arranged on the right side of the injection device, an ultrasonic device is arranged above the three-way pipe, an injection device is arranged on the right side of the three-way pipe, and a control device is arranged on the right side of the injection device. Through the arrangement ofa pressure sensor and an alarm lamp, during anesthesia medicine injection, the pressure of injection liquid can be monitored, high-pressure injection is avoided, and nerve injuries or neurological dysfunction are avoided. The anesthetic injection position is detected through ultrasound, precise anesthesia is achieved, extra pain caused by repeated blind detection to a patient is avoided, the anesthesia efficiency and safety are improved, and the medication cost is reduced. The injection speed is controlled through a motor, and low-pressure anesthetic injection can be conducted smoothly.

The invention discloses an intraspinal anesthetic and a preparation method and an application thereof. The intraspinal anesthetic comprises dexmedetomidine, epinephrine, betamethasone and water for injection. The preparation method comprises the following steps: (1) after the betamethasone and the epinephrine are mixed and 50% of water for injection of the full dose are added, uniformly mixing; (2) after the dexmedetomidine is mixed in a mixing solution in step (1), adding the water for injection to full dose, and uniformly mixing; (3) filtrating and sterilizing the mixing solution in step (2) to obtain the intraspinal anesthetic. The invention further provides the application of the intraspinal anesthetic in the preparation of the intraspinal anesthetic. According to the intraspinal anesthetic provided by the invention, the neurovirulent effect caused by using local anesthetics to the intraspinal anesthesia can be prevented; furthermore, the intraspinal anesthetic has the effects of analgesia, calm, muscle relaxation and adverse areflexia and shiver prevention, can evade the adverse effects of the vein use and can be used for special patients.

It is disclosed a needle (1) for a syringe, including a tip (2) at one end (3) of the needle, adapted to penetrate a body tissue during usage of the syringe, and a hub (4) at the other end (5) of the needle, to attach the needle to the syringe. A pressure sensor (6) is in the needle; means (7) are provided to transmit outside the needle a pressure value sensed by the pressure sensor (6) in the needle.

The invention relates to a variable-angle V-shaped double-channel working sheath for spine endoscopic surgery. The variable-angle V-shaped double-channel working sheath comprises a working sheath grab handle body, wherein a clamping ring is arranged on the working sheath grab handle body and used for being connected with a detachable connecting grab handle or a robot or a mechanical arm, and the working sheath grab handle body is provided with a working sheath channel I and a working sheath channel II which are independent of each other; and the bottoms of the working sheath channel I and the working sheath channel II are connected side by side through an elastic rotating shaft, the tops of the working sheath channel I and the working sheath channel II are jointly connected to an elastic opening structure, and an endoscope locking depth adjuster is further embedded in the upper end of the working sheath channel I. The angles of the two channels of the working sheath can be adjusted, the depth of the connected endoscope can be adjusted in real time, windows are formed in the tail ends of the instrument channels, the flexibility of instrument operation is improved, the endoscope is prevented from being damaged, the injury risk generated by surgical instruments is reduced, and the situation that the surgical instruments cannot be observed by the endoscope in the surgical process is avoided.