54results about How to "Avoid nerve damage" patented technology

Neurophysiological instruments and techniques are improved through various enhancements. Stimulation of an instrument is possible while it is advancing into the spine or elsewhere, alerting the surgeon to the first sign the instrument or device (screw) may be too near a nerve. A directional probe helps surgeons determine the location of the hole in the pedicle. Electrically insulating sleeves prevent shunting into the soft tissues. According to a different improvement, the same probe to be used to stimulate different devices, such as screws and wires. Electrical impulses may be recorded from non-muscle regions of the body, including the spine and other portions of the central nervous system as opposed to just the extremities.

The subject invention provides methods of treating a subject afflicted with Parkinson's disease, memory disorder, depression, hyperactive syndrome, Attention Deficit Disorder, dementia, brain ischemia, stroke, head trauma injury, spinal trauma injury, neurotrauma, neurodegenerative disease, neurotoxic injury, multiple sclerosis, nerve damage, affective illness, schizophrenia or symptoms of withdrawal from an addictive substance, using the mesylate salt of R(+)-N-propargyl-1-aminoindan.

Macrocyclic derivative compounds that inhibit protein kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and / or disturbed kinase activity such as cancers, psoriasis, viral and bacterial infections, inflammatory and autoimmune diseases.

Neurophysiological instruments and techniques are improved through various enhancements. Stimulation of an instrument is possible while it is advancing into the spine or elsewhere, alerting the surgeon to the first sign the instrument or device (screw) may be too near a nerve. A directional probe helps surgeons determine the location of the hole in the pedicle. Electrically insulating sleeves prevent shunting into the soft tissues. According to a different improvement, the same probe to be used to stimulate different devices, such as screws and wires. Electrical impulses may be recorded from non-muscle regions of the body, including the spine and other portions of the central nervous system as opposed to just the extremities.

The invention relates to an artificial temporal-mandibular joint replacement prosthesis. The replacement prosthesis comprises a glenoid fossa prosthesis and a mandible ramus prosthesis; the glenoid fossa prosthesis is made of supra polymer polyethylene polymer and comprises a tissue surface in contact with the glenoid fossa and a function surface in contact with the mandible ramus prosthesis, the tissue surface comprises a wing plate which is in contact with the zygomatic arch and is fixed to the zygomatic arch and a protrusion part in contact with the glenoid fossa, and the function surface comprises a sunken part in contact with the mandible ramus prosthesis and stopping plates arranged at the two ends of the sunken part; and the mandible ramus prosthesis comprises a condyloid process head and a mandible ramus fixing handle, the condyloid process head is cylindral and is in contact with the sunken part, the mandible ramus fixing handle is attached to the outer lateral face of the mandible ramus. By means of the artificial temporal-mandibular joint replacement prosthesis, the standard form artificial joint prosthesis is more suitable for the dissection appearance of the Chinese and is better attached to the jaw, complications in and after an operation are effectively reduced, the using effect of the standard form artificial joint prosthesis is improved, and the service life of the standard form artificial joint prosthesis is prolonged.

An optical nerve stimulation system for optically stimulating and locating a nerve, includes: a laser radiation source positioned adjacent to the nerve and configured to deliver laser radiation to the nerve through one or more optical fibers, thereby heating it; wherein the laser radiation source is operated in a continuous-wave mode; and a temperature sensor positioned adjacent to the nerve and a feedback loop configured to control the laser radiation source such that a predetermined temperature is maintained. The laser radiation source is one or more of an infrared laser and a near-infrared laser. Optionally, the laser radiation has a wavelength of between 1400 and 1900 nm. The one or more optical fibers are one or more single-mode fibers. The ONS probe includes one or more SMFs with chemically-etched tips and lenses for providing collimation and / or beam shaping to provide a flat-top spatial beam profile.

The invention provides new methods for treating certain disorders resulting from neurodegeneration and for treating depression which comprise administration of NR2B subunit selective NMDA antagonists. The disorders that can be treating by the invention include hearing loss, vision loss, neurodegeneration caused by epileptic seizures, neurotoxin poisoning, Restless Leg Syndrome, multi-system atrophy, non-vascular headache, and depression.

The invention discloses a lumbar endoscopic fusion technology assisted by electromagnetic navigation, and particularly relates to the technical field of lumbar minimally invasive surgeries. The technology comprises the following specific steps: 1 carrying out image matching; 2 registering an open-circuit cone; 3 registering a puncture needle, a guide rod and a working channel; 4 registering a trephine; and 5 registering an instrument under the microscope. The steps 1 to 5 are combined with an electromagnetic navigation technology, visualization of the whole surgery process is achieved, surgical instruments are continuously tracked, intraoperative fluoroscopy is avoided, the surgery time is shortened, intraoperative radiation of patients and medical staff is reduced, an operation path is planned before operation, the angle and the position of the instruments can be adjusted in time according to a holographic image presented by the electromagnetic navigation system during the surgery, so that the precision of the surgery is realized, repeated adjustment of a pipeline, excessive traction of muscles and unnecessary excision of a bony structure are avoided, nerve injury is avoided, and the surgery effect is ensured.

The invention discloses a novel method for a drug loading system constructed by means of sensitization blood platelets for treating immune thrombocytopenia. The method comprises the steps that firstly, whole blood is anti-coagulated and centrifuged to obtain platelet rich plasma, then, deep centrifuging washing is performed to obtain washed platelets, the washed platelets react with CD41 monoclonal antibody oscillation, and centrifuging is performed to obtain the CD41 monoclonal antibody modified target macrophage sensitization blood platelets; then, the sensitization blood platelets and an immunosuppressor or a chemically modified cytotoxic drugs are mixed and incubated, centrifuging and purifying are performed, and finally the sensitization blood platelet drug loading system carrying drug for resisting immune thrombocytopenia is obtained. The drug loading system has the advantages of being abundant in source, high in drug loading rate, good in biocompatibility, high in targeting, long in cycle time and the like, the drug can precisely target macrophage, and the concentration of the drug inside the macrophage is increased, so that the drug curative effect is improved, and meanwhile the toxic and side effect on normal tissue is effectively relieved.

The invention relates to the technical field of tissue engineering, in particular to a Schwarm progenitor cell derived from a marrow neural crest cell and application of the Schwarm progenitor cell to promotion of nerve regeneration. The rat marrow-derived neural crest cell N1, namely, BM-NCC clone N1, is provided, the preservation number is CCTCC NO:C201647, and the rat marrow-derived neural crest cell N1 has the performance of the Schwarm progenitor cell (SCP). The invention further provides a subculture method of the BM-NCC clone N1 and a method for induced directional differentiation to the Schwarm cell (SC). The BM-NCC clone N1 is expected to be applied to nerve regeneration promotion therapy based on cells.

The invention discloses an intraspinal anesthetic and a preparation method and an application thereof. The intraspinal anesthetic comprises dexmedetomidine, epinephrine, betamethasone and water for injection. The preparation method comprises the following steps: (1) after the betamethasone and the epinephrine are mixed and 50% of water for injection of the full dose are added, uniformly mixing; (2) after the dexmedetomidine is mixed in a mixing solution in step (1), adding the water for injection to full dose, and uniformly mixing; (3) filtrating and sterilizing the mixing solution in step (2) to obtain the intraspinal anesthetic. The invention further provides the application of the intraspinal anesthetic in the preparation of the intraspinal anesthetic. According to the intraspinal anesthetic provided by the invention, the neurovirulent effect caused by using local anesthetics to the intraspinal anesthesia can be prevented; furthermore, the intraspinal anesthetic has the effects of analgesia, calm, muscle relaxation and adverse areflexia and shiver prevention, can evade the adverse effects of the vein use and can be used for special patients.