Instant adhesive tissue patch and preparation method thereof

A tissue and patch technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve problems such as greater inflammatory response, insufficient softness of materials, erosion of abdominal wall organs, etc., to avoid nerve damage and save operation time Effect

Inactive Publication Date: 2020-07-28
天津百和至远医疗技术有限公司
View PDF6 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, the commonly used clinical hernia repair patch is usually made of polypropylene material, which has many advantages such as low density, corrosion resistance, and moderate inflammatory stimulation, but also has disadvantages: if it cannot be used with Viscera are in direct contact, easy to adhere, and erode the abdominal wall organs; the material is not soft enough, which may cause a greater inflammatory reaction, etc.
The commonly used method of mesh mesh fixation is to fix the mesh to the tissue with absorbable or non-absorbable surgical sutures or "puck pins", but either way may cause tissue or Patients with postoperative chronic pain due to nerve damage
[0004] In addition, it has been reported in the literature that folding and displacement of the mesh mesh due to poor fixation after implantation, resulting in hard and sharp edges, caused patients with a strong sense of foreign body and discomfort after surgery, and even intestinal fistula, Severe complications such as bladder fistula

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Instant adhesive tissue patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Preparation of fibrinogen mixed solution

[0044] Fibrinogen is dissolved in phosphate buffer, and XIII factor, fibronectin, polyethylene glycol (PEG), glycerol and aprotinin solution are added, and the concentration of fibrinogen in the prepared mixed solution is 110 mg / ml, and the concentration of XIII factor The concentration is 40U / ml, the concentration of fibronectin is 6mg / ml, the concentration of polyethylene glycol is 50mg / ml, the concentration of glycerol is 300mg / ml, and the concentration of aprotinin is 300KU / ml. Adjust the pH of the solution to 7.0.

[0045] 2. Extraction and purification of prothrombin

[0046] Take an appropriate amount of fresh pig blood and centrifuge for 10 minutes at 3°C ​​and 5500r / min to remove blood cells. Next, the collected plasma was diluted with 10-fold deionized water and stirred, and then the pH of the solution was adjusted to 5.0 with 2 mol / L acetic acid. Then the solution was transferred to a refrigerator, and stood at...

Embodiment 2

[0056] 1. Preparation of fibrinogen mixed solution

[0057] Dissolve fibrinogen in phosphate buffer, add XⅢ factor, fibronectin, polyethylene glycol (PEG), glycerol and aprotinin solution, the concentration of fibrinogen in the prepared mixed solution is 200mg / ml, XⅢ factor The concentration is 80U / ml, the concentration of fibronectin is 10mg / ml, the concentration of polyethylene glycol is 100mg / ml, the concentration of glycerol is 100mg / ml, and the concentration of aprotinin is 200KU / ml. Adjust the pH of the solution to 6.5.

[0058] 2. Extraction and purification of prothrombin

[0059] Take an appropriate amount of fresh pig blood and centrifuge for 10 minutes at 3°C ​​and 5500r / min to remove blood cells. Next, the collected plasma was diluted with 10-fold deionized water and stirred, and then the pH of the solution was adjusted to 5.0 with 2 mol / L acetic acid. Then the solution was transferred to a refrigerator, and stood at 4° C. for 12 hours, and the precipitate was c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to an instant adhesive tissue patch and a preparation method thereof, and belongs to the technical field of medical materials. The instant adhesive tissue patch comprises a meshsubstrate, the mesh substrate is coated with a fibrinogen complex layer and a prothrombin layer, and the fibrinogen complex layer and the prothrombin layer are frozen at an ultralow temperature. The instant adhesive tissue patch can be rapidly attached to tissue without suture lines or drawing pins, so that nerve injury caused by fixation can be avoided and operation time is greatly saved; the patch is directly placed at an operation defect part in use, and thrombin and fibrinogen are crosslinked in a body fluid wet environment to quickly form fibrin glue for fixing the patch to the tissue; and the effects of rapid hemostasis and wound healing can be achieved at the same time.

Description

technical field [0001] The invention relates to the technical field of medical materials, more specifically, the invention relates to an instant adhesive tissue patch and a preparation method thereof. Background technique [0002] Tension-free repair using a mesh mesh is widely accepted in soft tissue defect repair. During the tissue healing process after the mesh mesh is implanted, the extracellular matrix produced by the granulation tissue penetrates and grows into the mesh structure of the mesh, thereby strengthening the tissue at the surgical site and serving the purpose of hernia repair. [0003] In the prior art, the commonly used clinical hernia repair patch is usually made of polypropylene material, which has many advantages such as low density, corrosion resistance, and moderate inflammatory stimulation, but also has disadvantages: if it cannot be used with The viscera are in direct contact with each other, which is easy to adhere and erode the abdominal wall organ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/40A61L27/22A61L27/18A61L27/54
CPCA61L27/18A61L27/225A61L27/227A61L27/54A61L2300/252A61L2300/254A61L2300/418A61L2430/34C08L71/02C08L89/00
Inventor 张世超尹俊娇
Owner 天津百和至远医疗技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap