The invention discloses a viral hepatitis treatment drug interferon production technology which comprises the following steps: (1) acquisition of a target gene; (2) amplifying by PCR (polymerase chain reaction), to be more specific, in a microcentrifuge tube, using the 1 g / mL target gene obtained by the step (1) as template DNA, adding a right amount of a buffer solution, 4 kinds of dNTP (diethyl-nitrophenyl thiophosphate) mixtures, 0.5 2.5U / 50 muL DNA polymerase system, a pair of 0.1-0.5 mumol / L synthesized DNA primer to make the system pH 6.8-7.8; (3) gene recombination; (4) transformation; (5) separation and purification; (6) gene expression; (7) modification; and (8) freeze-drying, mass viral hepatitis treatment drug interferon can be produced in a short period of time, after modifying with polyethylene glycol, the half-life of the interferon is prolonged, hepatitis virus targeting property is improved, the antigenicity is weak, no human body immune response is caused, drug efficacy is good, production is fixed, stability is good, and the viral hepatitis treatment drug interferon production technology is suitable for popularization and application.