An amplifier circuit includes a power amplifier biased for saturated mode operation, and a controllable current source to provide supply current to the power amplifier. The controllable current source effects desired amplitude modulation of the output signal from the power amplifier by modulating the supply current it provides responsive to an amplitude information signal. In one or more embodiments, the current source includes a circuit that is configured to adjust one or more transmitter operating parameters responsive to detecting changes in the effective DC resistance of the power amplifier. For example, the circuit may generate a compensation signal that reduces the effective DC resistance responsive to detecting that the effective DC resistance has undesirably increased. By way of non-limiting examples, such compensation may be effected by changing a current mirror, an amplifier-to-antenna impedance matching, an amplifier bias or device size, or imposing some form of transmit signal back-off.