34 results about "Time to hemostasis" patented technology

Disclosed are methods and devices for obtaining patent hemostasis of the radial artery by compressing the uninstrumented ulnar artery to increase radial artery flow. The device comprises a band having an inflatable bladder for applying blunt pressure to the ulnar artery. The method comprises applying a pressure to the homolateral ulnar artery and applying a pressure to the radial artery at the access site to obtain hemostasis at the access site. The method further comprises administering an anticoagulant to a patient at a dose ranging from about 20 units per kg of body weight to about 30 units per kg of body weight.

Disclosed are methods and devices for obtaining patent hemostasis of the radial artery by compressing the uninstrumented ulnar artery to increase radial artery flow. The device comprises a band having an inflatable bladder for applying blunt pressure to the ulnar artery. The method comprises applying a pressure to the homolateral ulnar artery and applying a pressure to the radial artery at the access site to obtain hemostasis at the access site. The method further comprises administering an anticoagulant to a patient at a dose ranging from about 20 units per kg of body weight to about 30 units per kg of body weight.

The invention discloses a micro / nano graded porous microsphere, a preparation method and application thereof. The preparation method comprises the following steps: (1) preparing a mixed solution of chitin nanofibers and chitosan; (2) preparing Pickering emulsion; (3) preparing micro / nano graded porous microspheres. The preparation method of the present invention is simple, the reaction conditions are mild, and the cost is low. The prepared microspheres prevent red blood cells and platelets from entering the microspheres by controlling the size of the pores on the outer surface, thereby shortening the hemostasis time of wounds and promoting wound repair; the pore walls of the microspheres are made of chitin nano Fibrous junctions can simulate the collagen fiber morphology in the subendothelial matrix of vascular tissue, adhere to and activate platelets, help accelerate hemostasis, and effectively absorb wound blood to keep the wound dry; when chitosan contacts with blood, its polycation structure and The binding force between its molecules and the cell membrane makes whole blood coagulate, accelerates the process of hemostasis, inhibits wound infection and promotes cell proliferation at the same time.

The invention discloses a starch-based microporous hemostatic material with antibacterial properties, a preparation method and application thereof. The present invention first prepares starch-based microporous starch, and then loads amino ions, thereby finally preparing a pore size of 0.1-6 μm, a hemostasis time of 20s-4min, a bactericidal rate of 50%-100%, and 4h-10d that can be completely degraded in vivo Positively charged starch-based microporous hemostatic material. The material can quickly and effectively stop bleeding and also has antibacterial function, which can prevent infection of the wound site and accelerate wound healing, but has no damage to normal cells. The present invention adopts starch with wide sources and low price as raw material, and loads amino groups after microporation, thus preparing a hemostatic material with physical and chemical hemostatic mechanism, which has fast hemostatic speed, high viscosity and good biocompatibility. It degrades quickly in the body, has a wide range of applications, and has dual functions of hemostasis and antibacterial.

The invention relates to a method for preparing a porous hemostatic gel dressing based on human-like collagen and zeolite. The mass ratio of zeolite to human-like collagen is 1:10-1:20, adding an appropriate amount of zeolite to the LHC solution, adding inorganic salts and Stir the complex cross-linking agent β-diimine zinc complex and 1,2,7,8-diepoxyoctane evenly, adjust the pH value of the solution to acidic conditions, and place it in a 40-80°C water bath to maintain 0.5- After 5 hours, high-temperature steam treatment and water washing are repeated twice to remove salt and cross-linking agent residues. After drying and Co-60 sterilization, a zeolite-containing hemostatic gel dressing can be obtained. In addition to the good breathability, anti-adhesion and rapid hemostatic effect of this material, the gel medium itself disperses the zeolite particles, which greatly alleviates the exothermic problem caused by the zeolite during the hemostatic effect. Compared with the situation without introducing zeolite gel, the hemostasis time is significantly shortened to 15-25s on average.

The invention discloses an absorbable rapid bleeding stopping material and a preparation method thereof. The material comprises medicine carrying calcium alginate porous microspheres, oyster shell powder and sodium carboxymethylcellulose. The medicine carrying calcium alginate porous microspheres and the oyster shell powder have the following two functions: firstly, the medicine carrying calcium alginate porous microspheres and the oyster shell powder serve as a molecular sieve, and can rapidly absorb the water in blood when making contact with the blood, so that visible components in the blood can be rapidly concentrated; secondly, the medicine carrying calcium alginate porous microspheres and the oyster shell powder can release a large number of calcium ions for acting on blood coagulation factors which are concentrated on the material surface, blood coagulation is accelerated, bleeding stopping time is shortened, and the amount of bleeding is reduced. The adopted materials are natural macromolecule polysaccharide and inorganic salt, and the characteristics of good biocompatibility, biodegradability, safety, non-toxicity, absorbability, bleeding stopping ability and the like are achieved. The preparation process is simple, the medicine can be released continuously and steadily within a certain period of time, and the absorbable rapid bleeding stopping material can bring great benefits to the medical field and the society.

The invention provides a fluid hemostatic glue and a preparation method thereof. The fluid hemostatic glue comprises cross-linked chitosan or a derivative thereof, cross-linked water-soluble protein or polypeptide, and a lubricant. The hemostatic glue according to the present invention does not contain coagulation factors, is in the form of a flowable ointment, has a suitable swelling degree, can be used directly without any time-consuming reconstruction steps, has short hemostasis time, fast wound healing, and is easy to use. Fast, degradable in vivo, and good biocompatibility.

A hemostatic material based on a combination of chitosan and tissue factor and a preparation method thereof, aiming at short hemostatic time and good hemostatic effect; the main components of the hemostatic material and their formula in parts by mass are: 100 parts of chitosan, human Recombinant tissue factor 0.1-0.2 milliparts, phospholipids 0.04-0.06 parts, trehalose 0.1-0.2 parts, CaCl 2 0.04-0.08 part; the preparation method is to prepare human recombinant tissue factor and phospholipids into an emulsion under high pressure, and then add 0.02 ml of emulsion per gram of carboxymethyl chitosan to prepare carboxymethyl chitosan and human recombinant tissue Factor mixture; pre-freeze at -40°C to -80°C for 5-10 hours and then vacuum freeze-dry; at an ambient temperature of 15-20°C and a humidity of 30%, grind it through a 100-mesh sieve into powder for external use Rapid hemostasis material.

The invention belongs to the field of medical auxiliary instruments, and relates to a tourniquet capable of depressurizing automatically and regularly. The tourniquet comprises a tourniquet body, styptic cotton, a tightening unit, a control unit, a timer, sensors and an energy supplying unit, the tourniquet body is used for wrapping a wounded part of a user, the styptic cotton is used for stoppingbleeding of the wounded part of the user, the tightening unit is used for applying pressure on the styptic cotton to stop bleeding or relieving the pressure applied on the styptic cotton, the sensorsare used for acquiring data in a bleeding stopping process, and the control unit is used for controlling actions of the tightening unit according to the data acquired by the sensors. The tourniquet has the advantages that pressing strength and pressing time can be quantized, bleeding stopping time in the bleeding stopping process can be guaranteed effectively, a bleeding stopping effect can be affirmed in the bleeding stopping process, operations of medical workers is facilitated, medical efficiency can be increased effectively, and the circumstance of flooding or long-time blood stopping canbe avoided.

The present disclosure relates to a method for preparing an absorbable haemostatic composition for the body and the haemostatic composition prepared thereby, and the present disclosure is for providing a method for preparing an absorbable haemostatic composition for the body and the haemostatic composition prepared thereby, wherein the haemostatic composition can be used directly on the wound site when bleeding occurs in the surgical area such as surgical operation, trauma, etc. so that hemostasis can be effectively performed, the haemostatic composition can perform wound sealing, tissue repairing promotion, wound surface tissue protection, infection prevention, etc., the haemostatic composition is contained in haemostatic products such as gauze (cotton yarn), sponge, etc. to accelerate the hemostasis speed of the bleeding site and enable rapid hemostasis to be able to shorten the hemostasis time at the same time.