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Low-cost antimicrobial and hemostasis ointment and preparation method thereof

A low-cost, molecular sieve technology, used in pharmaceutical formulations, pharmaceutical science, drug delivery, etc., can solve problems such as cost of use and poor mechanical properties, and achieve good hemostatic effects, good bacteriostatic properties, and easy portability.

Inactive Publication Date: 2016-10-12
王泽陆
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a low-cost antibacterial hemostatic plaster and its preparation method for existing hemostatic materials in terms of hemostatic effect, poor use cost and mechanical properties.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The hemostatic paste described in this embodiment is composed of the following components by weight: 40 parts of hydroxymethyl chitosan, 11 parts of corn starch, 7 parts of aminodextran, 4 parts of potassium alginate, 4 parts of earthworm dry powder, 4 parts of molecular sieve 8 parts of water-soluble polysaccharide, 14 parts of tricalcium phosphate, 8 parts of vitamin E acetate, 7 parts of lanthanum phosphate, 12 parts of glycerin, 62 parts of double distilled water;

[0024] The water-soluble polysaccharide is hydroxymethylcellulose.

[0025] The molecular sieve is ETS-10 molecular sieve.

[0026] The preparation method of the low-cost antibacterial hemostatic plaster described in this embodiment comprises the following preparation steps:

[0027] (1) Put water-soluble polysaccharides, tricalcium phosphate, aminodextran, potassium alginate, lanthanum phosphate, molecular sieve, and earthworm dry powder in double distilled water, stir them evenly, and place them in a ...

Embodiment 2

[0032] The hemostatic paste described in this embodiment is composed of the following components by weight: 60 parts of hydroxymethyl chitosan, 18 parts of cornstarch, 15 parts of aminodextran, 10 parts of potassium alginate, 12 parts of earthworm dry powder, 9 parts of molecular sieve 16 parts of water-soluble polysaccharide, 30 parts of tricalcium phosphate, 15 parts of vitamin E acetate, 12 parts of lanthanum phosphate, 27 parts of glycerin, 90 parts of double distilled water;

[0033] The water-soluble polysaccharide is alginate.

[0034] The molecular sieve is ZSM-5 molecular sieve.

[0035] The preparation method of the low-cost antibacterial hemostatic plaster described in this embodiment comprises the following preparation steps:

[0036] (1) Put water-soluble polysaccharides, tricalcium phosphate, aminodextran, potassium alginate, lanthanum phosphate, molecular sieve, and earthworm dry powder in double distilled water, stir evenly, and place in a constant temperature...

Embodiment 3

[0041] The hemostatic paste described in this embodiment consists of the following components by weight: 50 parts of hydroxymethyl chitosan, 15 parts of cornstarch, 11 parts of aminodextran, 7 parts of potassium alginate, 8 parts of earthworm dry powder, and 6 parts of molecular sieves , 12 parts of water-soluble polysaccharide, 22 parts of tricalcium phosphate, 12 parts of vitamin E acetate, 10 parts of lanthanum phosphate, 20 parts of glycerin, 76 parts of double distilled water;

[0042] The water-soluble polysaccharide is hydroxymethylcellulose and guar gum, and the mass ratio of the two is 1:3.

[0043] The molecular sieve is ETS-10 molecular sieve.

[0044] The preparation method of the low-cost antibacterial hemostatic plaster described in this embodiment comprises the following preparation steps:

[0045] (1) Put water-soluble polysaccharides, tricalcium phosphate, aminodextran, potassium alginate, lanthanum phosphate, molecular sieve, and earthworm dry powder in doub...

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PUM

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Abstract

The invention discloses a low-cost antimicrobial and hemostasis ointment and a preparation method thereof. The hemostasis ointment is prepared from, by weight 40-60 parts of cafboxymethyl chitosan, 11-18 parts of corn starch, 7-15 parts of aminated dextran, 4-10 parts of potassium alginate, 4-12 parts of earthworm dry powder, 4-9 parts of molecular sieves, 8-16 parts of water-soluble polysaccharide, 14-30 parts of tricalcium phosphate, 8-15 parts of vitamin E acetate, 7-12 parts of lanthanum phosphate, 12-27 parts of glycerinum and 62-90 parts of double distilled water. The hemostasis ointment is short in hemostasis time and small in bleeding amount, the antimicrobial rate is larger than 98.7%, the good hemostasis effect and the good antimicrobial performance in the preliminary stage of a wound are shown, the biological compatibility is good, and the hemostasis ointment is convenient to carry and has the good application prospect.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a low-cost antibacterial hemostatic plaster and a preparation method thereof. Background technique [0002] In daily life, whether it is emergency treatment of various sudden accidents or trauma hemostasis in the process of treatment, it is very important for patients to effectively and quickly stop bleeding locally; The death rate from the cause of hemorrhage remains high. Therefore, it is of great significance to develop an effective rapid hemostatic material to accelerate the speed of coagulation, and to reduce the mortality rate caused by excessive blood loss. [0003] Currently commonly used hemostatic materials are: gelatin sponge and gelatin fiber mesh, alginate, collagen, chitosan and its derivatives, cellulose and oxidized regenerated cellulose, starch and zeolite. However, these hemostatic materials have more or less deficiencies and defects in environm...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/0023A61L2300/112A61L2300/232A61L2300/30A61L2300/404A61L2300/418A61L2400/04C08L5/02C08L3/02
Inventor 王泽陆
Owner 王泽陆
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