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A kind of preparation method of novel medical hemostatic gel dressing

A hemostatic gel and human-like collagen technology, applied in the field of medical materials, can solve the problems of poor air permeability and easy adhesion of wounds, etc., and achieve the effects of good biocompatibility, strengthening cross-linking, and promoting cross-linking reaction.

Active Publication Date: 2020-02-18
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the defects of poor gas permeability and easy adhesion to wounds of hemostatic materials on the market, the present invention prepares a new type of medical hemostatic gel dressing that can quickly stop bleeding and does not adhere to tissues. The method is simple in process and the prepared material is biocompatible Good performance, it is expected to be widely used in wartime first aid kits, clinical operation hemostasis, etc.

Method used

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  • A kind of preparation method of novel medical hemostatic gel dressing
  • A kind of preparation method of novel medical hemostatic gel dressing
  • A kind of preparation method of novel medical hemostatic gel dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of medical hemostatic porous gel dressing

[0026] Step 1: Dissolve the water-soluble human-like collagen HLC in 10 mL distilled water to obtain a solution with a concentration of 100 mg / mL, and add cross-linking agent β-diimine zinc complex and 1,2,7 , 1 mL each of 8-dioxoctane, then add 2 mL of 10 mg / mL KCl, mix well, and adjust the pH of the solution to 4.5 with dilute hydrochloric acid and sodium hydroxide;

[0027] Step 2: Divide the mixed solution in step 1 into molds, keep at 50°C for 2 hours, then transfer to a high-pressure steam sterilizer and keep at 121°C for 20 minutes to obtain the primary gel product;

[0028] Step 3: soak and wash the primary gel in step 2 with distilled water for 5 days, change the washing water every 6 hours to remove salt and residual cross-linking agent; transfer the washed primary gel to an autoclave to continue Keep at 121°C for 2 h, then soak and wash with distilled water for 2 days again, control the total ...

Embodiment 2

[0033] Example 2 Preparation of medical hemostatic porous gel dressing

[0034] Step 1: Dissolve the water-soluble human-like collagen HLC in 10 mL distilled water to obtain a solution with a concentration of 100 mg / mL, and add 2% cross-linking agent β-diimine zinc complex and 1,2,7 , 1 mL each of 8-dioxoctane, and then add 10 mg / mL Na 2 SO 4 Solution 2mL, mix well, and adjust the pH of the solution to 4 with dilute hydrochloric acid and sodium hydroxide;

[0035] Step 2: Divide the mixed solution in step 1 into molds, keep it in a water bath at 60°C for 2 hours, then transfer it to a high-pressure steam sterilizer and keep it at 110°C for 20 minutes to obtain the primary gel product;

[0036] Step 3: soak and wash the primary gel in step 2 with distilled water for 5 days, change the washing water every 6 hours to remove salt and residual cross-linking agent; transfer the washed primary gel to an autoclave to continue Keep at 110°C for 2 h, then soak and wash with distilled w...

Embodiment 3

[0039] Example 3 Preparation of medical hemostatic porous gel dressing

[0040] Step 1: Dissolve the water-soluble human-like collagen HLC in 20 mL distilled water to obtain a solution with a concentration of 200 mg / mL, and add cross-linking agent β-diimine zinc complex and 1,2,7 , 4 mL each of 8-dioxoctane, and then add 10 mg / mL NaH 2 PO 4 Solution 2mL, mix well, and adjust the pH of the solution to 5.5 with dilute hydrochloric acid and sodium hydroxide;

[0041] Step 2: Divide the mixed solution in step 1 into molds, keep it at 70°C for 2 hours, then transfer it to a high-pressure steam sterilizer and keep it at 121°C for 20 minutes to obtain the primary gel product;

[0042] Step 3: soak and wash the primary gel in step 2 with distilled water for 4 days, change the washing water every 6 hours to remove salt and residual cross-linking agent; transfer the washed primary gel to an autoclave to continue Keep at 121°C for 3 h, then soak and wash with distilled water for 1 day...

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Abstract

The invention relates to a method for preparing a medical hemostatic gel dressing. Human-like collagen (LHC) is dissolved in ultrapure water to prepare a protein solution, and inorganic salts and complex cross-linking agents β-diimine zinc complex and 1,2,7,8-Diepoxyoctane, adjust the pH value of the solution to 2-5.5, stir evenly and place the mixed solution in a 40-80°C water bath for 0.5-5h, and then undergo two high-temperature steam treatments in sequence After washing with water, drying and Co-60 irradiation sterilization, a new type of sterile medical hemostatic gel dressing can be obtained. The medical hemostatic gel dressing prepared by the invention has good air permeability and antibacterial properties, will not cause wound infection, and can significantly shorten the hemostasis time. The hemostatic material will not adhere to the wound after hemostasis is completed, which significantly reduces the patient's pain.

Description

technical field [0001] The invention relates to a preparation method of a medical hemostatic gel dressing, which belongs to the field of medical materials. Background technique [0002] Bleeding due to war, traffic accidents, sports or disease and other factors that cause various epidermal or tissue traumas in the body. In recent years, many studies have shown that a large proportion of patients died of excessive blood loss clinically. Therefore, it is an urgent need to prepare a hemostatic material that can quickly stop bleeding without sticking to the tissue to gain time for later rescue and treatment. solved problem. [0003] The main characteristics of ideal dressings currently used for wounds are generally: non-toxic, non-sensitive, and non-allergic; closely attached to the wound, and have good hygroscopic properties, which can keep the environment moist between the wound and the dressing; frequent dressings are not required. Replacement; impermeable to microorganisms...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00A61L24/10A61L24/00C08J3/24C08L89/00
CPCA61L24/0031A61L24/0036A61L24/102A61L26/0033A61L26/008A61L26/0085A61L2400/04C08J3/243C08J2389/00
Inventor 郑晓燕范代娣惠俊峰朱晨辉马晓轩姜西娟
Owner NORTHWEST UNIV
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