Method for preparing absorbable haemostatic composition for body and haemostatic composition prepared thereby

Abstract

The present disclosure relates to a method for preparing an absorbable haemostatic composition for the body and the haemostatic composition prepared thereby, and the present disclosure is for providing a method for preparing an absorbable haemostatic composition for the body and the haemostatic composition prepared thereby, wherein the haemostatic composition can be used directly on the wound site when bleeding occurs in the surgical area such as surgical operation, trauma, etc. so that hemostasis can be effectively performed, the haemostatic composition can perform wound sealing, tissue repairing promotion, wound surface tissue protection, infection prevention, etc., the haemostatic composition is contained in haemostatic products such as gauze (cotton yarn), sponge, etc. to accelerate the hemostasis speed of the bleeding site and enable rapid hemostasis to be able to shorten the hemostasis time at the same time.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the priority of Korean Patent Application No. 10-2020-0170826 filed on Dec. 8, 2020, in the Korean Intellectual Property Office, the disclosure of which is incorporated herein by reference.BACKGROUNDField[0002]The present disclosure relates to a method for preparing an absorbable haemostatic composition for the body and the haemostatic composition prepared thereby, and more particularly, to a method for preparing an absorbable haemostatic composition for the body, the composition which is contained in gauze, sponge, etc. used as haemostatic products in the surgical area to promote hemostasis and enable rapid hemostasis at the same time, and which contains gelatin and kaolin to effectively act on a bleeding site, thereby having excellent hemostasis action and haemostatic effect, and the haemostatic composition prepared thereby.Description of the Related Art[0003]Blood is composed of plasma, which is a liquid compone...

AI Technical Summary

Benefits of technology

The present disclosure provides a method for preparing an absorbable haemostatic composition for the body, which can be used directly on a wound site to effectively hemostasis, promote wound sealing, tissue repairing, and prevent infection. The haemostatic composition can be contained in haemostatic products such as gauze or sponge to accelerate the hemostasis speed. It is easily absorbed and decomposed in vivo, has excellent biocompatibility and non-toxic to the living body. It also acts quickly to prevent rebleeding, has a low manufacturing cost, and is more efficient in achieving a continuous haemostatic effect.

Problems solved by technology

However, when capillary bleeding from parenchymal organs or bleeding from vascular anastomosis occurs, there are cases where the above-described haemostatic methods are not effective.

Due to this, in the field of cardiovascular surgery, it may cause difficulties in hemostasis when surgery is performed using the anticoagulant heparin, when there is a tendency to bleed due to liver failure, or when performing a surgery accompanied by extensive dissection operation even during general surgery.

Here, the haemostatic agent made of cellulose has had advantages of being inexpensive and excellent in operability, but there has been a problem in that the haemostatic ability is not sufficient since the material itself does not have a physiologically active action, the haemostatic agent made of gelatin, when it contains blood, has had problems in that the surface is gelled and the adhesiveness of the bleeding wound is damaged so that it is easy to peel, the haemostatic agent made of aterocollagen has had a toxicity problem with respect to chemicals since a crosslinking agent is used to fiberize atherocollagen, and the haemostatic agent made of microfibrous collagen has had problems in that the haemostatic effect is not large since it is formed to allow the microfibers of collagen to flow and disperse into the bleeding wound site, and static electricity is generated so that it is attached to the hand or tweezers when used.

Therefore, there is a demand for a haemostatic agent which has high haemostatic ability, is non-toxic to the living body when used in bleeding sites, is similar to living tissue, has no antigenicity that invades the living body to form antibodies, is easily decomposed and absorbed in the living body, and has an inexpensive manufacturing cost.

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