A kind of preparation method of hemostatic gel dressing containing zeolite

A technology of hemostatic gel and zeolite, applied in pharmaceutical formulations, bandages, drug delivery, etc., can solve the problems of patient pain, increase the difficulty of cleaning wounds for doctors, and burn wounds, shorten the hemostasis time, optimize the pore-forming effect, and promote communication. The effect of linked reactions

Active Publication Date: 2020-04-21
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the external hemostatic products currently on the market are zeolite hemostatic powder. When in use, zeolite hemostatic powder can be directly sprinkled on the wound, but it has the following disadvantages: first, directly sprinkle zeolite on the patient's wound, because zeolite will absorb water and release it. Second, zeolite is directly sprinkled on the wound, and it needs to be cleaned up after hemostasis, which not only increases the difficulty for doctors to clean up the wound, but also the remaining wound remains Zeolite particles may cause clogged blood vessels

Method used

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  • A kind of preparation method of hemostatic gel dressing containing zeolite
  • A kind of preparation method of hemostatic gel dressing containing zeolite
  • A kind of preparation method of hemostatic gel dressing containing zeolite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of zeolite-containing hemostatic gel dressing

[0024] Step 1: Take 10 mL of water-soluble human-like collagen solution with a mass concentration of 100 mg / mL, add zeolite at a mass ratio of 1:10 between zeolite and water-soluble human-like collagen, and then add a cross-linking agent with a concentration of 1%. Add 1 mL of β-diimine zinc complex and 1,2,7,8-dioxoctane each, then add 2 mL of 10 mg / mL KCl, mix well, and adjust the pH of the solution with dilute hydrochloric acid and sodium hydroxide solution to 4.5;

[0025] Step 2: Divide the mixed solution in step 1 into molds, keep at 50°C for 2 hours, then transfer to a high-pressure steam sterilizer and keep at 121°C for 20 minutes to obtain the primary gel product;

[0026] Step 3: soak and wash the primary gel in step 2 with distilled water for 5 days, change the washing water every 6 hours to remove salt and residual cross-linking agent; transfer the washed primary gel to an autoclave to co...

Embodiment 2

[0030] Example 2 Preparation of zeolite-containing hemostatic gel dressing

[0031] Step 1: Take 10 mL of water-soluble human-like collagen solution with a mass concentration of 200 mg / mL, add zeolite at a mass ratio of 1:15 between zeolite and water-soluble human-like collagen, and then add a cross-linking agent with a concentration of 1%. 2 mL each of β-diimine zinc complex and 1,2,7,8-dioxoctane, and then add 10 mg / mL Na 2 SO 4 2mL, mix well, and adjust the pH of the solution to 4 with dilute hydrochloric acid and sodium hydroxide solution;

[0032] Step 2: Divide the mixed solution in step 1 into molds, keep it in a water bath at 60°C for 2 hours, then transfer it to a high-pressure steam sterilizer and keep it at 110°C for 30 minutes to obtain the primary gel product;

[0033]Step 3: soak and wash the primary gel in step 2 with distilled water for 5 days, change the washing water every 6 hours to remove salt and residual cross-linking agent; transfer the washed primary...

Embodiment 3

[0036] Example 3 Preparation of zeolite-containing hemostatic gel dressing

[0037] Step 1: Take 10 mL of water-soluble human-like collagen solution with a mass concentration of 400 mg / mL, add zeolite at a mass ratio of 1:20 between zeolite and water-soluble human-like collagen, and then add a cross-linking agent with a concentration of 1%. Add 4 mL of β-diimine zinc complex and 1,2,7,8-dioxoctane each, then add 2 mL of 10 mg / mL NaCl, mix well, and adjust the pH of the solution with dilute hydrochloric acid and sodium hydroxide solution to 5;

[0038] Step 2: Divide the mixed solution in step 1 into molds, keep it in a water bath at 70°C for 2 hours, then transfer it to a high-pressure steam sterilizer and keep it at 121°C for 15 minutes to obtain the primary gel;

[0039] Step 3: soak and wash the primary gel in step 2 with distilled water for 5 days, change the washing water every 6 hours to remove salt and residual cross-linking agent; transfer the washed primary gel to an...

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Abstract

The invention relates to a method for preparing a porous hemostatic gel dressing based on human-like collagen and zeolite. The mass ratio of zeolite to human-like collagen is 1:10-1:20, adding an appropriate amount of zeolite to the LHC solution, adding inorganic salts and Stir the complex cross-linking agent β-diimine zinc complex and 1,2,7,8-diepoxyoctane evenly, adjust the pH value of the solution to acidic conditions, and place it in a 40-80°C water bath to maintain 0.5- After 5 hours, high-temperature steam treatment and water washing are repeated twice to remove salt and cross-linking agent residues. After drying and Co-60 sterilization, a zeolite-containing hemostatic gel dressing can be obtained. In addition to the good breathability, anti-adhesion and rapid hemostatic effect of this material, the gel medium itself disperses the zeolite particles, which greatly alleviates the exothermic problem caused by the zeolite during the hemostatic effect. Compared with the situation without introducing zeolite gel, the hemostasis time is significantly shortened to 15-25s on average.

Description

technical field [0001] The invention relates to a preparation method of a zeolite-containing hemostatic gel dressing, which belongs to the technical field of medical hemostatic materials. Background technique [0002] Zeolite is a general term for porous hydrous aluminosilicate crystals with a framework structure. Zeolite has a strong skeleton structure, and there are large-volume voids such as cavities and channels inside. At the same time, there are many micropores and channels of uniform size inside the crystal lattice, and the volume can account for more than 50% of the volume of zeolite. The micropores and channels are interconnected, giving the zeolite a large surface area. Therefore, zeolite has high water absorption rate and water absorption capacity. When zeolite is used in hemostatic materials, it can absorb water in blood, concentrate platelets and coagulation factors, and achieve the purpose of hemostasis. The use of zeolite hemostatic dressings has been widely...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08J3/24C08L89/00
CPCA61L26/0004A61L26/0033A61L26/008A61L26/0085A61L2400/04C08J3/243C08J2389/00C08L89/06
Inventor 郑晓燕范代娣惠俊峰段志广李伟娜姜西娟
Owner NORTHWEST UNIV
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