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34 results about "Tilmicosin phosphate" patented technology
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Tilmicosin phosphate is a antibiotic, is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia (Pasteurella) haemolytica.
Method for synthesizing tilmicosin and tilmicosin phosphate through using tylosin broth
ActiveCN102659878ALow costReduce manufacturing costSugar derivativesSugar derivatives preparationOrganic solventPhosphorylation
A method for synthesizing tilmicosin and tilmicosin phosphate through using a tylosin broth is disclosed. The method is characterized in that the method comprises the following process steps: preprocessing the tylosin broth to obtain a tylosin filtrate; allowing the tylosin filtrate to undergo extraction, ammonification, reextraction, hydrolysis, acidification liquid extraction and vacuum drying to obtain tilmicosin; and allowing the obtained tilmicosin to undergo phosphorylation and spray drying to obtain tilmicosin phosphate. The method, which directly extracts the tylosin broth which is the initial raw material to synthesize the tilmicosin and the tilmicosin phosphate, allows the production procedure to be simplified, the product production time to be shortened, reaction conditions of the whole technology to be mild, the operation to be simple, the production process to be safe and reliable, and the organic solvent loss to be less, and has the advantages of energy saving and consumption reduction, high finished product yield, low production cost, high working efficiency and the like.
Owner:宁夏泰瑞制药股份有限公司
Tilmicosin phosphate enteric granules and preparation method thereof
InactiveCN103622919AAvoid destructionProlong the action timeAntibacterial agentsOrganic active ingredientsEmulsionAdhesive
The invention discloses tilmicosin phosphate enteric granules and a preparation method thereof. The enteric granules comprise 70-80 wt% of elemental granule and 20-30 wt% of coating, wherein the elemental granules are at least prepared from the following components in percentage by mass: 5-40% of tilmicosin phosphate, 30-55% of microcrystalline cellulose, 1-5% of sodium carboxymethyl starch, 26.9-30% of starch, 0.1-1% of surfactant and 2-4% of adhesive; and the coatings are at least prepared from the following components in percentage by mass: 78.9-90.9% of I acrylic resin emulsion, 2.3-7.9% of triethyl citrate and 6.8-13.2% of talcum powder. The coatings are coated outside the tilmicosin phosphate elemental granules, so that the tilmicosin phosphate enteric granules are basically not released in the livestock or fowl stomach, but are gradually and completely released in the livestock or fowl intestinal tract, thereby obviously enhancing the treatment effect of the tilmicosin phosphate.
Owner:HUBEI LONGXIANG PHARMA TECH CO LTD
Compound doxycycline hyclate suspension injection and preparation method thereof
InactiveCN102440998AFacilitated releaseHigh speedAntibacterial agentsTetracycline active ingredientsDoxycycline HyclateAntioxidant
The invention discloses a compound doxycycline hyclate suspension injection and a preparation process thereof. The suspension injection is prepared by taking doxycycline hyclate and tilmicosin phosphate as main medicines and adding appropriate medical accessories. The compound doxycycline hyclate suspension injection comprises the following components: 5-20 percent (W / V) of doxycycline hyclate, 5-20 percent (W / V) of tilmicosin phosphate, 0.5-2 percent (W / V) of a suspending aid, 0.01-0.2 percent (W / V) of an antioxidant, 0.1-2 percent (V / V) percent of a thickening agent and injection oil which supplements the balance to reach 100 percent. According to the invention, the doxycycline hyclate and the tilmicosin phosphate are evenly suspended into a solvent by a special process, and therefore the compound doxycycline hyclate suspension injection has good dispersibility and high bioavailability. Meanwhile, a feasible approach is provided for broadened production, and the advantages of increasing medical efficacy, reducing medication frequency and saving manpower and material resources are achieved.
Owner:TIANJIN RINGPU BIO TECH
Improved extended-action tilmicosin and use thereof in treatment of bovine respiratory disease complex (BRD) and in dry cow period
InactiveUS20160367580A1Improved extended actionFacilitated releaseAntibacterial agentsOrganic active ingredientsAlcoholMedicine
The invention relates to an improved long-acting or extended-release tilmicosin formulation comprising: tilmicosin phosphate in a concentration between 35 and 50% by weight of the total composition; a first co-solvent in a concentration between 8 and 20% by volume, said first co-solvent being propylene glycol; a second co-solvent in a concentration between 5 and 15% by volume, said second co-solvent being ethyl alcohol; and an emulsifier in a concentration between 1.5 and 15% by weight of the total composition, said emulsifier being poloxamer. The invention also relates to the method for producing said improved long-acting tilmicosin formulation.
Owner:UNIV NAT AUTONOMA DE MEXICO
Tilmicosin phosphate preparation method
ActiveCN105837648ASimple production processShorten the production cycleSugar derivativesSugar derivatives preparationOrganic solventPhosphorylation
The invention relates to a tilmicosin phosphate preparation method. The preparation method comprises that through hydrolysis under acidic conditions, alkalization extraction, amination, phosphorylation with phosphoric pentoxide and a small amount of water, full stirring salification, centrifugation separation after solid precipitation and vacuum drying, tilmicosin phosphate is prepared from tylosin tartrate as a raw material. According to the preparation method, phosphoric pentoxide and a small amount of water are directly added into an amination liquid, the mixture undergoes a phosphorylation reaction and tilmicosin phosphate is precipitated from the organic solvent. The preparation method has a final mole yield of 95% or more and a simple process route, can be operated easily, is free of spray drying production equipment, has a low production cost and realizes recycle of an organic solvent.
Owner:HUBEI LONGXIANG PHARMA TECH CO LTD
Milk fragrance type tilmicosin enteric microcapsule and preparation method thereof
The invention relates to a milk fragrance type tilmicosin enteric microcapsule, and belongs to the technical filed of veterinary drugs. The tilmicosin enteric microcapsule is composes of a capsule core layer and a capsule coat layer; wherein the capsule core layer is composed of tilmicosin or tilmicosin phosphate and proper auxiliary materials, and the capsule coat layer is composed of a composite enteric material. The milk fragrance type tilmicosin enteric microcapsule can radically cover the bitterness of tilmicosin, and has a high encapsulation rate and a small microcapsule particle size.
Owner:RINGPU TIANJIN BIOLOGICAL PHARMA
Tilmicosin solution and preparation method thereof
InactiveCN101584657AReduce manufacturing costAntibacterial agentsOrganic active ingredientsFiltrationSodium bisulfite
The invention relates to a tilmicosin solution, mainly comprising injection water, tilmicosin and sodium bisulfite; 100ml of injection water contains 7.5-20g of tilmicosin and 0.05-0.2g of sodium bisulfite. The invention further relates to a preparation method of the tilmicosin solution, comprising partially weighing the injection water, regulating pH value, adding the tilmicosin, then adding the sodium bisulfite, supplying the injection water, adding active carbon, decarbonization and filtration. The invention solves the problem that tilmicosin phosphate is required to prepare the tilmicosin solution in the prior art and makes up for the shortage of the prior art.
Owner:上海恒丰强生物技术有限公司
Detection method for residual solvent in tilmicosin phosphate
ActiveCN103645252AConstant temperature detection is simpleEasy to operateComponent separationChromatographic separationGas phase
A detection method for a residual solvent in tilmicosin phosphate comprises: preparing a reference substance solution, preparing a to-be-detected sample solution, employing a gas chromatography method, injecting the reference substance solution and the to-be-detected sample solution into a gas chromatograph by a headspace sampling manner, and calculating the residual quantity according to an external standard method. Through optimization of chromatographic conditions and the tests on preparation methods of the to-be-detected sample and the reference substance, a gas chromatograph method is established for detecting residues such as butyl acetate and n-butanol possibly existing in tilmicosin phosphate; through optimization of the chromatographic separation system, the detection method for the residual solvent in the veterinary drug tilmicosin phosphate; methodological verification tests show that the established method is high in accuracy, strong in specificity and good in reproducibility; and by controlling the content of the residual solvent in the veterinary drug tilmicosin phosphate, the safety of the veterinary drug tilmicosin phosphate is guaranteed, and thus infectious diseases of animals such as cattle, goat, sheep, cow, pig, chicken and the like are relatively effectively controlled.
Owner:宁夏泰瑞制药股份有限公司
Veterinary compound florfenicol injection and preparation method thereof
ActiveCN102133213ADoes not affect weight gainQuick resultsAntibacterial agentsInorganic phosphorous active ingredientsDoxycycline HyclatePhosphoric acid
The invention discloses compound florfenicol injection and a preparation method thereof. The compound florfenicol injection comprises the following components: 500g of florfenicol, 500g of doxycycline hyclate, 500g of tilmicosin phosphate, 3,000g of polyvinylpyrrolidone, 4,000g of N, N-dimethylacetylamide, 200g of magnesium chloride, 20g of sodium formaldehyde sulphoxylate and 10,000 milliliters of water for injection. The preparation method comprises the following steps of: (1) preparing; (2) adding doxycycline into the polyvinylpyrrolidone, heating to 80 DEG C, stirring until a mixture is clarified, adding the tilmicosin phosphate, and stirring until a mixture is clarified; (3) heating dimethylacetylamide to 50 DEG C, adding the florfenicol, and stirring for dissolving; (4) adding 1,000 milliliters of water for injection, adding the magnesium chloride and the sodium formaldehyde sulphoxylate in turn, and stirring for dissolving; and (5) mixing solution prepared in the step (2) and the step (3), gradually adding solution prepared in the step (4) under stirring, replenishing the water for injection until the total volume of the water for injection is 10,000 milliliters, uniformly stirring, filtering, filling nitrogen, encapsulating, and sterilizing at the temperature of between 110 and 115 DEG C for 30 minutes to prepare the compound florfenicol injection.
Owner:HUBEI WUDANG ANIMAL PHARMA
Preparation method of tilmicosin phosphate crystal
ActiveCN103288904AAvoid pollutionReduce pollutionSugar derivativesSugar derivatives preparationPhosphoric acidEthyl acetate
The invention relates to a preparation method of a tilmicosin phosphate crystal. The method comprises the following steps of: firstly fully dissolving tilmicosin phosphate powder in ethyl acetate, then slowly dripping isopropyl ether under the temperature condition of 0-5 DEG C in a stirring state for mixing, keeping the stirring state for 30-60min after the end of dripping, and performing solid-liquid separation, leaching and vacuum drying. According to the preparation method disclosed by the invention, tilmicosin phosphate is prepared into crystal particles, and the crystal particles are used for replacing the powder; as the specific gravity of the crystal particles is lager, the dust pollution can be avoided during packaging and using processes; furthermore, drinking water for animals is added, the crystal particles are easy to settle down into the water bottom, the dispersion is better, the dissolution speed is higher, the content is higher, and the crystal particles can be directly added into animal feed or the drinking water for the animals; and in addition, a solvent is very easy to recover, and the tilmicosin phosphate crystal further has certain application prospects in production.
Owner:宁夏泰瑞制药股份有限公司
Tilmicosin-plant essential oil composition
InactiveCN106729720AImprove palatabilityIncrease production capacityAntibacterial agentsOrganic active ingredientsDiseaseFeed conversion ratio
The invention discloses a tilmicosin-plant essential oil composition. The composition contains the following components in percentage by weight: 5%-30% of a tilmicosin raw material, 1%-10% of a plant essential oil raw material and the balance of auxiliary materials, wherein the tilmicosin raw material is tilmicosin or tilmicosin phosphate or tilmicosin tartrate or salt of other tilmicosin. By virtue of compatibility of the tilmicosin and one or more plant essential oil in use, the use amount of an antibiotic can be effectively reduced, drug pollution and residue can be reduced, furthermore, animal diseases can be effectively prevented and treated, the immunity of animals can be enhanced, the feed conversion ratio can be decreased, and the productivity of the animals can be improved, so that the use effect is greatly improved, the raising cost is lowered, and the tilmicosin-plant essential oil composition has wide application prospects in the animal breeding industry.
Owner:FOSHAN STANDARD BIO TECH
Method for producing tilmicosin and tilmicosin phosphate by utilizing tylosin fermentation broth
InactiveCN108864227ARepeatedly adjust the pHThe production process route is short and efficientSugar derivativesSugar derivatives preparationOrganic solventPhosphoric acid
The invention belongs to the field of pharmacy and particularly discloses a method for producing tilmicosin and tilmicosin phosphate by utilizing a tylosin fermentation broth. The method comprises thefollowing steps of performing hydrolysis pretreatment and filtering on the tylosin fermentation broth to obtain a tylosin B filtrate, then performing extraction separation on the tylosin B filtrate,performing catalyzed synthesis to obtain the tilmicosin, performing water-phase extraction, decoloration, crystallization and solid-liquid separation to obtain a wet tilmicosin solid, and drying the wet tilmicosin solid to obtain a tilmicosin product, or dissolving the wet tilmicosin solid with strong phosphoric acid to prepare a tilmicosin phosphate product. In the method, by directly taking thetylosin fermentation broth as a starting material to extract and synthesize the tilmicosin product or the tilmicosin phosphate product, the production technology is simplified, the production time isremarkably shortened, the production efficiency is improved, the yield of the product is increased, the quality of the product is improved, the production cost is lowered, loss of an organic solvent is reduced, emission of the three wastes is remarkably reduced, and the method has the advantages of energy conservation, consumption reduction, safe environment, excellent quality, cost reduction andthe like.
Owner:CHINA ANIMAL HUSBANDRY IND
Production method for improving quality of tilmicosin phosphate
PendingCN114133417AShorten the timeQuality improvementSugar derivativesSugar derivatives preparationAcetic acid butyl esterMedicinal chemistry
The invention relates to a production method for improving the quality of tilmicosin phosphate, which is characterized in that anhydrous sodium sulfate is added into extract liquor for stirring treatment after butyl acetate extraction for 20-40 minutes and before amination synthesis, so that on one hand, the standing water separation time of butyl acetate extraction is greatly shortened, and the standing water separation time of the extraction in the original process needs 5-6 hours; and after the anhydrous sodium sulfate is added, the water separation time is 30-60 minutes, so that the production time is shortened. On the other hand, moisture in the extract liquor is greatly removed, and a specific amount of anhydrous sodium sulfate is added at a specific time, so that the moisture in the extract liquor is lower than 2.0%, the subsequent inadequate amination reaction is avoided, the amination reaction is thorough, the mass of tilmicosin phosphate is improved, and the total impurity content is reduced by 3.0%.
Owner:QILU PHARMA INNER MONGOLIA
Compound tilmicosin phosphate-ambroxol nanoemulsion preparation
InactiveCN105012332ATransparent appearanceConvenient clinical administrationAntibacterial agentsOrganic active ingredientsActive agentSurface-active agents
The invention discloses a compound tilmicosin phosphate-ambroxol nanoemulsion preparation and a preparation method thereof. The nanoemulsion preparation is oil-in-water type, has a particle size of 1-100nm, and is prepared from tilmicosin phosphate, ambroxol, a surfactant, a co-surfactant, ethyl acetate and distilled water. The drug is a light yellow clarified liquid, and ahs the characteristics of simple preparation process, low production cost, obvious absorption effect and high stability, and can improve the bioavailability of drugs.
Owner:HEBEI KEHENG BIOTECH
Composition for treating porcine respiratory tract infection and preparation method of composition
InactiveCN107441111AReduce chance of drug resistanceImprove antibacterial propertiesTetracycline active ingredientsAntiinfectivesChlortetracycline HydrochlorideFumaric acid
The invention relates to a composition for treating porcine respiratory tract infection and a preparation method of the composition. The composition is prepared from the following raw materials in percentage by weight: 1-5 % of marbofloxacin, 1-5 % of tiamulin fumarate, 5-15 % of tilmicosin phosphate, 5-15 % of lincomycin hydrochloride, 5-15 % of chlortetracycline hydrochloride, the balance of anhydrous glucose. All the components are grinded, the obtained powder is screened by adopting a No.5 sieve, the screened powder is sufficiently and uniformly mixed, and thus the composition for treating porcine respiratory tract infection is obtained. Compared with the prior art, the composition has the advantages that the plurality of medicines which can be mixed for use are comprehensively selected, the situation that some pathogenic bacteria have drug resistance to some medicines, consequently, treatment failure is caused, is avoided, the drug resistance probability of pathogens is reduced, so that the pathogenic microorganism resisting range is wide, the antibacterial effect is strong, and disease recovery is facilitated.
Owner:JIANGXI AOXIN BIOTECH CO LTD +1
Traditional Chinese and western medicine compound oral liquid for treating porcine respiratory disease, and preparation method and application of compound oral liquid
InactiveCN107998265AMask bitternessOvercome the major difficulty of severe decline in feed intakeOrganic active ingredientsDispersion deliveryDiseaseSucrose
The invention relates to traditional Chinese and western medicine compound oral liquid for treating a porcine respiratory disease, and a preparation method and an application of the compound oral liquid, and belongs to the field of veterinary medicines. The preparation method of the traditional Chinese and western medicine compound oral liquid comprises the following steps of dissolving a folium eriobotryae extract, a fritillaria cirrhosa extract, tilmicosin phosphate, menthol, essence, sucrose and an auxiliary material. The preparation method is simple, good in condition controllability, lowin production cost and high in stability and has good application prospects. The traditional Chinese and western medicine compound oral liquid prepared by the method can effectively cover bitterness of an ordinary tilmicosin medicine, overcome the great difficulty of serious reduction of porcine feed intake caused by an ordinary tilmicosin pharmaceutical preparation and avoid resistance to the tilmicosin medicine, and has the advantages that the oral liquid takes effect quickly, is absorbed well, and is low in waste and cost. The oral liquid is used for preparing a medicine for treating or preventing the porcine respiratory disease, and has a better treatment effect on the porcine respiratory disease and only smaller influence on the porcine feed intake.
Owner:FUJIAN AONONG BIOLOGICAL TECH GRP CO LTD +1
Three-stage composition for preventing and controlling porcine respiratory diseases and application thereof
ActiveCN106721319APrevent and manage the risk of respiratory diseasesReduce morbidityOrganic active ingredientsFood processingComposition BRespiratory disease
The present invention discloses a three-stage composition for preventing and controlling porcine respiratory diseases. The composition comprises a composition A used in weaning period of piglets, a composition B used in conservation period and a composition C used in fattening period. The composition A comprises fermented licorice extract, folium artemisiae argyi extract, loquat leaf extract, a coated tilmicosin phosphate preparation and zeolite powder; the composition B comprises echinacea purpurea extract and radix astragali extract; and the composition C comprises corns, soybean meal, wheat bran and homemade special premixes. In addition, the present invention also discloses an application of the three-stage composition used for preparing feed additives or feeds for preventing and controlling the porcine respiratory diseases. According to the occurrence regularity of the respiratory diseases of live pigs, the different compositions in the three stages are firstly used to prevent and control the occurrence of the porcine respiratory diseases. The three-stage composition is very ideal in effects, can effectively prevent and control the occurrence of the respiratory diseases and has the characteristics of being accurate in curative effects, not easy to produce drug resistance and relapse, etc.
Owner:CHANGSHA LVYE BIOTECHNOLOGY CO LTD
Production method for coating tilmicosin by agar
InactiveCN105012958APromote gastrointestinal motilityImprove immunityOrganic active ingredientsDigestive systemHigh concentrationMotility
The invention relates to the field of veterinary drugs and preparation, in particular to a production method for coating tilmicosin by agar. The method includes the following steps that A, tilmicosin powder is weighed or high-concentration tilmicosin phosphate solution is prepared; B, agar powder is weighed, distilled water is added to the agar powder, and the mixture is heated to be melted; C, when the agar solution is cooled to be not hot and kept in the solution state, a proper amount of tilmicosin powder or tilmicosin mother solution is added to the agar solution, the final concentration of the agar is made to be larger than 0.8% (coating the tilmicosin powder) or larger than 0.5% (coating the tilmicosin phosphate solution), the mixture is evenly mixed and then poured into a container in a required shape, and a product is obtained after the mixture is fully cooled and solidified; D, sample detection is conducted on the product, and the effects of covering up the bitter taste and slow release of the product are detected; E, packaging is conducted. According to the production method, the tilmicosin is coated by the agar, the bitter taste of the tilmicosin is covered up, meanwhile the slow release function is achieved, and the coating medium agar further has the effects of improving the animal intestine and gastrointestinal motility, improving the immunity and the like.
Owner:芜湖神农百草生物科技有限公司
Detection method for residual solvent in tilmicosin phosphate
ActiveCN103645252BConstant temperature detection is simpleEasy to operateComponent separationBiotechnologyChromatographic separation
Owner:宁夏泰瑞制药股份有限公司
Tilmicosin phosphate immune colloidal gold detection card and preparation method thereof
The invention provides a tilmicosin phosphate immune colloidal gold detection card and a preparation method thereof, and relates to the technical field of detection of antibiotics. According to the present invention, the tilmicosin phosphate immune colloidal gold detection card comprises a PVC glue plate, a sample pad, a colloidal gold conjugation pad, a coating membrane and a water absorbing pad, wherein the colloidal gold membrane is a glass cellulose membrane containing tilmicosin phosphate monoclonal antibody, the coating membrane is a nitrocellulose membrane and is provided with a T line and a C line, a tilmicosin phosphate protein conjugate is coated on the T line, and a goat anti-mouse IgG antibody is coated on the C line; and the detection card is effectively used for tilmicosin phosphate detection, and has advantages of convenience, rapidness, and accurate result.
Owner:JIANGSU WISE SCI & TECH DEV
Preparation method of tilmicosin phosphate crystal
ActiveCN103288904BAvoid pollutionReduce pollutionSugar derivativesSugar derivatives preparationPhosphoric acidEthyl acetate
Owner:宁夏泰瑞制药股份有限公司
Tilmicosin phosphate preparation method
InactiveCN107383114APlay a role in purificationHigh puritySugar derivativesSugar derivatives preparationCentrifugationPhosphoric acid
The invention relates to a tilmicosin phosphate preparation method, which comprises: adding tilmicosin to a certain proportion of purified water, heating, adding phosphoric acid in a dropwise manner to adjust the pH value so as to dissolve, filtering, cooling, adding a sedimentation agent to precipitate a crystal, carrying out centrifugation, and drying, wherein the obtained product is tilmicosin phosphate. According to the present invention, the preparation method has advantages of safety, environmental protection, good product quality and low cost, and can be used for industrial production; and the produced product has advantages of high purity and good stability.
Owner:SHANDONG JIULONG HISINCE PHARMA CO LTD
Method for preparing efficient tilmicosin premixing agent through adsorption crystallization and application of efficient tilmicosin premixing agent
ActiveCN114712313AImprove adsorption capacityCrystallize fastAntibacterial agentsOrganic active ingredientsPhosphoric acidPharmaceutical drug
The invention relates to A61K, in particular to a method for preparing an efficient tilmicosin premixing agent through adsorption crystallization and application of the efficient tilmicosin premixing agent. Comprising the following steps: adsorption crystallization: spraying a tilmicosin mixed solution into a porous material, and carrying out boiling drying at 50-100 DEG C for 10-15 minutes; by controlling the water content and the adsorption capacity of the porous material, adsorption of the tilmicosin mixed solution is promoted, and meanwhile, solvent water and the like in the tilmicosin mixed solution are controlled to be taken out by sucking and discharging boiling dry airflow at a certain temperature in a pore channel of the porous material with high adsorption capacity; therefore, the tilmicosin or the tilmicosin phosphate is promoted to rapidly crystallize in a short time and is adsorbed in the pore channels of the porous material to form adsorption crystals. Plant extract components can be further added after adsorption and crystallization, so that the effects of enhancing immunity, resisting inflammation, resisting oxidation, improving drug effects, reducing side effects of drugs and the like are achieved, or the taste of the preparation is improved, and the first-mouth selectivity and the long-term feed intake are improved.
Owner:HUNAN DANWEI BILOGICALTECH
Preparation method of tilmicosin phosphate microsphere specifically for use on animals
ActiveCN102302456BHigh encapsulation efficiencySimple preparation processAntibacterial agentsOrganic active ingredientsParaffin waxAcrylic resin
Owner:长沙施比龙动物药业有限公司
A kind of tilmicosin phosphate soluble powder preparation and preparation method thereof
ActiveCN105796499BImprove stabilityImprove palatabilityAntibacterial agentsOrganic active ingredientsSolubilityPhosphate
The invention relates to a tilmicosin phosphate soluble powder preparation and a preparation method thereof. The soluble powder preparation is prepared from the following components in parts by weight: 5-30 parts of tilmicosin phosphate, 2-30 parts of a sweetening agent, 2-20 parts of an adhesive and 20-91 parts of parts of a water-soluble diluent. The tilmicosin phosphate soluble powder provided by the invention has mobility, solubility and palatability; moisture absorption and agglomeration are not easily generated; and the stability is obviously superior to that of existing soluble powder.
Owner:HUBEI LONGXIANG PHARMA TECH CO LTD
A kind of preparation method of tilmicosin phosphate
ActiveCN105837648BSimple production processShorten the production cycleSugar derivativesSugar derivatives preparationOrganic solventPhosphorylation
The invention relates to a tilmicosin phosphate preparation method. The preparation method comprises that through hydrolysis under acidic conditions, alkalization extraction, amination, phosphorylation with phosphoric pentoxide and a small amount of water, full stirring salification, centrifugation separation after solid precipitation and vacuum drying, tilmicosin phosphate is prepared from tylosin tartrate as a raw material. According to the preparation method, phosphoric pentoxide and a small amount of water are directly added into an amination liquid, the mixture undergoes a phosphorylation reaction and tilmicosin phosphate is precipitated from the organic solvent. The preparation method has a final mole yield of 95% or more and a simple process route, can be operated easily, is free of spray drying production equipment, has a low production cost and realizes recycle of an organic solvent.
Owner:HUBEI LONGXIANG PHARMA TECH CO LTD
Method for synthesizing tilmicosin and tilmicosin phosphate through using tylosin broth
ActiveCN102659878BLow costReduce manufacturing costSugar derivativesSugar derivatives preparationOrganic solventPhosphorylation
Owner:宁夏泰瑞制药股份有限公司
Veterinary compound florfenicol injection and preparation method thereof
ActiveCN102133213BDoes not affect weight gainQuick resultsAntibacterial agentsInorganic phosphorous active ingredientsDoxycycline HyclatePhosphoric acid
The invention discloses compound florfenicol injection and a preparation method thereof. The compound florfenicol injection comprises the following components: 500g of florfenicol, 500g of doxycycline hyclate, 500g of tilmicosin phosphate, 3,000g of polyvinylpyrrolidone, 4,000g of N, N-dimethylacetylamide, 200g of magnesium chloride, 20g of sodium formaldehyde sulphoxylate and 10,000 milliliters of water for injection. The preparation method comprises the following steps of: (1) preparing; (2) adding doxycycline into the polyvinylpyrrolidone, heating to 80 DEG C, stirring until a mixture is clarified, adding the tilmicosin phosphate, and stirring until a mixture is clarified; (3) heating dimethylacetylamide to 50 DEG C, adding the florfenicol, and stirring for dissolving; (4) adding 1,000 milliliters of water for injection, adding the magnesium chloride and the sodium formaldehyde sulphoxylate in turn, and stirring for dissolving; and (5) mixing solution prepared in the step (2) and the step (3), gradually adding solution prepared in the step (4) under stirring, replenishing the water for injection until the total volume of the water for injection is 10,000 milliliters, uniformly stirring, filtering, filling nitrogen, encapsulating, and sterilizing at the temperature of between 110 and 115 DEG C for 30 minutes to prepare the compound florfenicol injection.
Owner:HUBEI WUDANG ANIMAL PHARMA
Water-soluble tilmicosin phosphate as well as preparation method and application thereof
InactiveCN107383132AImprove palatabilityDoes not affect feedingAntibacterial agentsSugar derivativesBiotechnologyDisease
The invention relates to water-soluble tilmicosin phosphate as well as a preparation method and application thereof. The preparation method comprises the steps of adding a substance containing a phosphate radical into water for dissolving, heating to 50-70 DEG C, adding tilmicosin for dissolving, adjusting the pH value to 5.0-8.0 by virtue of an alkaline substance, maintaining the temperature for 15-30 minutes, adding a solid adsorbent, stirring, filtering, concentrating, and drying, so as to obtain water-soluble tilmicosin phosphate. Prepared water-soluble tilmicosin phosphate is used for preventing and treating respiratory tract infection of animal stud stocks and pets. Compared with the prior art, the preparation method has the advantages that water is taken as a solvent, so that the environmental pollution caused due to use of organic solvents such as DMF, toluene and dichloromethane is avoided; and a preparation prepared from water-soluble tilmicosin phosphate has good palatability, so that the ingestion of animals is not influenced; and water-soluble tilmicosin phosphate is applied to the prevention and control of animal diseases and has good mass uniformity and stability and very good application prospects.
Owner:JIANGXI AOXIN BIOTECH CO LTD +1
A "three-stage" composition for preventing and controlling porcine respiratory diseases and its application
ActiveCN106721319BEffective collaborative prevention and control of respiratory diseasesCollaborative prevention and control of respiratory diseasesOrganic active ingredientsFood processingBiotechnologyDisease
Owner:CHANGSHA LVYE BIOTECHNOLOGY CO LTD
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