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Production method for coating tilmicosin by agar

A technology of tilmicosin and production method, which is applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, digestive system, etc., can solve the problems of agar-containing tilmicosin, improve immunity, and improve animal gastrointestinal motility performance effect

Inactive Publication Date: 2015-11-04
芜湖神农百草生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tilmicosin coated with agar has not been reported so far

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0015] A kind of production method of agar-coated tilmicosin, comprises the following steps:

[0016] Step A, weigh 20mg tilmicosin powder;

[0017] Step B, weigh 1.2g of agar powder, add 80ml of distilled water, heat to make it melt completely, and obtain an agar solution;

[0018] Step C, when the agar solution obtained in step B is cooled to 50° C., add 20 mg of tilmicosin powder, at this time, add an appropriate amount of distilled water to make the total volume of the solution reach 100 ml, stir evenly and let it stand until it is fully solidified to obtain the product;

[0019] Step D, the product that obtains in the step C is carried out sampling inspection, detection product covers up bitter taste and slow-release effect: In addition, make a portion of 1.2 agar that does not contain tilmicosin as contrast; Prepare pig artificial gastric juice (NaCl6.915g, KCl0 .445g, distilled water 1000mL, adjust pH=2 with hydrochloric acid); Make tilmicosin standard curve (prepare a...

specific Embodiment 2

[0021] A kind of production method of agar-coated tilmicosin, comprises the following steps:

[0022] Step A, weigh 20 mg of tilmicosin powder, then dissolve it in phosphate buffer (NaCl137mmol / L, KCl2.7mmol / L, Na2HPO410mmol / L, KH2PO42mmol / L) and settle to 20ml to prepare tilmicosin Mother liquor;

[0023] Step B, weigh 1.2g of agar powder, add 80ml of distilled water, heat it to melt, and obtain an agar solution;

[0024] Step C, when the agar solution obtained in step B is cooled to 55° C., add 20 ml of tilmicosin mother solution to make the final concentration of agar 1.5%, stir evenly and let it stand until it is fully solidified to obtain the product;

[0025] Step D, the product obtained in the step C is sampled and detected, and the product is tested to cover the bitter taste and the slow-release effect (the detection method is the same as in Example 1): 1.2% agar is coated with 20 mg tilmicosin powder (total volume 100 ml) 1.57, 2.30, 2.85, 3.34, 3.71, 4.17, 4.58, 4....

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PUM

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Abstract

The invention relates to the field of veterinary drugs and preparation, in particular to a production method for coating tilmicosin by agar. The method includes the following steps that A, tilmicosin powder is weighed or high-concentration tilmicosin phosphate solution is prepared; B, agar powder is weighed, distilled water is added to the agar powder, and the mixture is heated to be melted; C, when the agar solution is cooled to be not hot and kept in the solution state, a proper amount of tilmicosin powder or tilmicosin mother solution is added to the agar solution, the final concentration of the agar is made to be larger than 0.8% (coating the tilmicosin powder) or larger than 0.5% (coating the tilmicosin phosphate solution), the mixture is evenly mixed and then poured into a container in a required shape, and a product is obtained after the mixture is fully cooled and solidified; D, sample detection is conducted on the product, and the effects of covering up the bitter taste and slow release of the product are detected; E, packaging is conducted. According to the production method, the tilmicosin is coated by the agar, the bitter taste of the tilmicosin is covered up, meanwhile the slow release function is achieved, and the coating medium agar further has the effects of improving the animal intestine and gastrointestinal motility, improving the immunity and the like.

Description

technical field [0001] The invention relates to the field of veterinary medicine and preparations, in particular to a production method of agar-coated tilmicosin. Background technique [0002] Due to the high density and other reasons, the large-scale animal breeding process often faces the threat of serious diseases, especially infectious diseases. Tilmicosin is mainly used for infectious diseases of cattle, dairy cows, goats, pigs, chickens and other animals, especially for livestock and poultry respiratory diseases such as livestock actinobacillus pleuropneumonia, pasteurellosis and chicken mycoplasma. It has inhibitory effect on gram-positive bacteria, some gram-negative bacteria, mycoplasma and spirochetes. As a special antibiotic for animals, tilmicosin is more and more favored by people because of its definite curative effect, remarkable effect and safe use in the treatment of livestock and poultry infections. In addition, the latest research shows that tilmicosin a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K31/706A61K31/729A61P1/14A61P37/04
Inventor 安静蔡春标安子健
Owner 芜湖神农百草生物科技有限公司
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