46 results about "Teichoic acid" patented technology

The invention provides a production process of a soy sauce flavor type soybean sauce. The soy sauce flavor type soybean sauce is prepared by using vinasse as a raw material, and aspergillus oryzae strains and bifidobacterium strains as strains. The production process is characterized in that with vinasse as the raw material, the production cost is reduced; and meanwhile, with bifidobacterium as a fermenting strain, the prepared soybean sauce contains nutritional ingredients such as lipoteichoic acid, membrane teichoic acid and peptidoglycan, so that the soybean sauce is endowed with a unique flavor, and the soybean sauce has the efficacies of enhancing the immunologic function and anti-tumour effect of the organism, relieving and removing fatigue, adjusting balance of intestinal microflora and improving the liver function, has nutritional benefits, and also has the efficacies of relieving uremia, resisting anaphylaxis, increasing the appetite, reducing blood pressure and blood cholesterol, preventing arteriosclerosis and the like, so as to promote health of a human body. The soybean sauce prepared by the production process is dark in color, and thick in juice, contains sugar but is not sweet, contains salt but is not salty, contains acid but is not sour, and has the unique thick soy sauce flavor.

Provided herein are compositions designed to reduce or prevent bacterial infections (for example pneuomococcal infections), nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a pneumococcal neuraminidase, phosphocholine, pneumococcal teichoic acid, pneumococcal lipoteichoic acid, or an antigenic portion of either neuraminidase, phosphocholine, pneumococcal teichoic acid, pneumococcal lipoteichoic acid. Optionally, the composition can comprise any combination of a pneumococcal neuraminidase, a phosphocholine, a pneumococcal teichoic acid, a pneumococcal lipoteichoic acid or an antigenic portion of any one of these. Optionally the agents are detoxified. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein. Also provided are methods of reducing or preventing nasal carriage or pneumococcal infection in a subject comprising administering to the subject a composition taught herein.

The invention discloses a preparation method of a functional lactobacillus acidophilus peptidoglycan and an anti-inflammatory activity use of the functional lactobacillus acidophilus peptidoglycan. The preparation method comprises the following steps of inoculating a MRS culture medium with lactobacillus acidophilus having an accession number of CGMCC No. 8920 according to an inoculation ratio of 2.0-4.0% by volume, carrying out anaerobic cultivation at a temperature of 37 DEG C for 18-24h, carrying out centrifugation under a centrifugation force of 4000-8000g for 15-20min so that a fermentation broth is removed, adding 4wt% of a SDS solution into the precipitated acidophilus peptidoglycan, carrying out high-temperature pyrolysis at a temperature of 100 DEG C for 30min to remove a protein component, adding 10wt% of a trichloroacetic acid solution into the precipitates to remove teichoic acid, carrying out overnight dialysis desalination on the precipitates at a temperature of 4 DEG C, carrying out pre-refrigeration on the precipitates at a temperature of -80 DEG C for 6h, fast putting the refrigerated precipitates into a drying device, and carrying out drying treatment under the pressure of 80-120Pa for 24h to obtain a powdery product. The functional lactobacillus acidophilus peptidoglycan has good inhibition and conditioning effects on LPS-caused inflammation.

The invention discloses an antibacterial wound-protecting hydrogel dressing and a preparation method thereof. The antibacterial wound-protecting hydrogel dressing comprises the following main components: a water-soluble chitosan derivative, matrix glue and a water-soluble high-molecular polymer. The preparation method comprises the following steps: preparing a chitosan derivative from purified water, fully and uniformly mixing the components, adding the chitosan derivative into a mold, adding a liquid matrix gel and an acrylamide solution, sequentially adding a crosslinking agent, an initiatorand an accelerator to form gel, and rinsing the gel with deionized water to remove the redundant crosslinking agent, thereby obtaining the hydrogel dressing. The dressing can absorb wound exudate andsecreta. The chitosan derivative has polycation, so that when being combined with negatively charged protein, teichoic acid and the like on the surface of thallus, the chitosan has strong antibacterial activity, and has unique advantages in prevention and treatment of wound infection. Matrix glue is one of extracellular matrixes, contains various bioactive components and plays an important role in the wound healing process. The hydrogel dressing can be applied to protection and repair of various types of wounds such as burns, wounds, pressure sores and the like.

The invention discloses a integrated peptidoglycan which can suppress tumor growth effectively and can be widely used in antitumor drugs due to the integrated spatial structure of the peptidoglycan extracted. The invention further discloses a method for extracting the integrated peptidoglycan, which comprises the following steps of: extracting teichoic acid to enhance membrane permeability, degreasing to remove fatty substances on the cell membranes, removing protein substances in the cells through an enzymatic solution, and finally centrifuging and cleaning to remove impurities and freeze-drying to obtain the whole peptidoglycan. The invention has the advantages that the cell wall has a whole structure since the integrated peptidoglycan is extracted, thereby having excellent antitumor effect. The preparation method has the advantages of strong practicability, simple operation, short period, simple and reasonable steps, low cost and high yield, and is suitable for large-scale production.

The invention relates to a soil heavy metal treating agent and an application thereof. The soil heavy metal treating agent consists of bacillus subtilis fermentation liquor, montmorillonite, furfural residues, gypsum powder and humic acid. According to the soil heavy metal treating agent, by virtue of special fermentation culture on bacillus subtilis, cell walls of the bacillus subtilis contain rich teichoic acid and peptidoglycan. Moreover, the montmorillonite, the furfural residues, the gypsum powder and the humic acid are combined, so that heavy metals in the soil can be quickly and efficiently reduced by the soil heavy metal treating agent.

The invention provides a soy sauce flavor type vinegar making process. Distillers' grains are utilized as the raw material to make the soy sauce flavor type vinegar, so that raw material cost is reduced, meanwhile a raw material alcoholic fermentation step is reduced, and the made vinegar has soy sauce flavor. Acetic acid strain and bifidobacterium strain are utilized as the vinegar making fermentation strain, and the made vinegar contains nutrient contents such as lactic acid, acetic acid, multivitamin, lipoteichoic acid, teichoic acid and peptidoglycan by means of control of temperature, oxygen and the like of all fermentation periods. The vinegar not only has the specific flavor of itself but also achieves the effects of enhancing the immunity of a human body, restraining cancer, remitting and removing fatigue, adjusting the balance of enteric microbial flora, improving the liver function, improving the nutrition effect, remitting the uremia, resisting allergy, increasing appetite, reducing blood pressure and cholesterol in blood, preventing arteriosclerosis and the like, so that the vinegar can further promote human body health, enhances national physical health and has good social and economical benefits. Therefore, the bifidobacterium vinegar is the modern novel healthcare vinegar which can enhance human body health and is cheap and fine.

The invention relates to a polyamine derivative medicinal salt and its preparation method and use in preparation of a drug for treating pyemia. The novel compound has good antagonistic action on a plurality of pyemia-causing pathogen-related molecules such as bacterial lipopolysaccharide (endotoxin), bacterial genome DNA, peptidoglycan, teichoic acid, virus RNA and zymosan, and can be used for preparation of a drug for treating pyemia.

The invention relates to a method for separating and refining isobomyl acetate. The method is characterized in that: an acetic acid solution containing water is produced on the top of a crude ester rectification tower; a mixture of camphene and acetic acid is mainly obtained through side take-off; a crude product of the isobomyl acetate is produced from the tower; and the crude product enters a refined ester evaporator, is whitened and then enters a refined ester vapor-liquid separation tank for separation so as to obtain high-purity isobomyl acetate. The disadvantages of high energy consumption of batch separation, low product yield and the like existing in the prior art are overcome; acid water is produced from the top of the crude ester rectification tower, crude ester is produced fromthe tower, the clear segmentation is realized by using a single tower, teichoic acid is produced from one side and only contains the acetic acid and the camphene, and when the teichoic acid is used for the circular reaction, the selectivity of the reaction is improved and the service life of a catalyst is prolonged, so the process is advanced and the energy consumption is low; and the method has the advantages of continuous production, compact flow, low energy consumption and the like, and the product is high in yield and has stable quality.

The invention provides a shampoo for treating seborrheic dermatitis, and belongs to the technical field of daily chemical products. The shampoo comprises a shampoo composition comprising a common bombax flower extract, a tea oil cake extract, monohydroxyethyl rutin and L-cysteic acid, a flaxseed extract and rice extract. The invention also provides a shampoo for repairing scalp damage and a methodof using the same. The shampoo for treating seborrheic dermatitis can promote staphylococcus epidermidis to secrete lipoteichoic acid, inhibiting phosphorylation induction of malassezia furfur to P65protein in the keratinocyte NF-kB pathways; the expression of partial glyceride lipase of malassezia globosa is inhibited to suppress the growth of the malassezia globosa, thereby alleviating the inflammatory response of the scalp and improving the treatment effect on the scalp seborrheic dermatitis.

The invention relates to a method for extracting peptidoglycan from Lactobacillus helveticus MB2-1. The method is characterized in that the permeability of cell walls is increased by physical and chemical methods, the physical method adopts an ultrasonic crushing method, and the chemical method adopts a trichloroacetic acid method to extract teichoic acid so as to increase the permeability of cell membranes. Fat substances on cell membranes are removed through degreasing of an organic reagent, protein substances in cells are removed through composite enzymatic hydrolysate, finally, impurities are removed through centrifugal cleaning, and freeze-drying is conducted to obtain peptidoglycan. The preparation method has the advantages that the extracted complete peptidoglycan with the probiotic effect is high in practicability, simple to operate, short in period, simple, convenient and reasonable in step, low in cost, high in yield and suitable for large-scale production.

The invention provides lactic acid bacteria teichoic acid gel for auxiliary therapy of vaginal diseases. The gel is finely prepared from the components including, by weight, 1-5 parts of lactic acid bacteria lipoteichoic acid, 10-50 parts of maltose oligosaccharide, 20-100 parts of kudzu root powder, 5-50 parts of hyaluronic acid, 5-10 parts of glycerin, and 500-5000 parts of distilled water. The lactic acid bacteria lipoteichoic acid in the gel can be adhered to vaginal epithelial cell acceptors to occupy ecological sites, thereby inhibiting adhesion of pathogenic bacteria; meanwhile, the kudzu root powder contains isoflavones that can be combined with steroid estrogen acceptors at low affinity to achieve the functions of the estrogen, thus improving proliferation of vaginal mucosa epithelium and reducing the pH in vagina. The gel has the effects of repairing damaged vagina and improving elasticity.