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30 results about "Skov3 cell" patented technology

Herba balanophorae involucratae extract and application thereof to preparation of anticancer medicine

The invention provides a herba balanophorae involucratae extract. The extract is an extract of an alcohol-soluble substance position obtained after herba balanophorae involucratae is subjected to water extraction and then is subjected to alcohol precipitation treatment or an extract of an ethyl-acetate position obtained after a supernatant solution, which is obtained after the herba balanophorae involucratae is subjected to the water extraction and then is subjected to the alcohol precipitation treatment, is abstracted through ethyl acetate or an extract of a water-extracted and alcohol-precipitated position obtained after a precipitate, which is obtained after the herba balanophorae involucratae is subjected to the water extraction and then is subjected to the alcohol precipitation treatment, is washed through alcohol and dried. According to the herba-balanophorae-involucratae extract, the herba-balanophorae-involucratae extract is applied to the preparation of a medicine for treatingan ovarian cancer and shown by an experiment, the herba-balanophorae-involucratae extract can be used for inhibiting the growth of A2780 and SKOV3 cells for the ovarian cancer in vitro in a dose-dependent manner, can be used for obviously inhibiting the growth of an A2780 nude-mice transplantation tumor in vivo and has a better effect.
Owner:CHINA THREE GORGES UNIV

Application of Chenopodolin in preparation of medicines for treating ovarian cancer

The invention discloses an application of Chenopodolin in preparation of medicines for treating an ovarian cancer, and belongs to the field of medicines. An in vitro test proves that the Chenopodolin is capable of inhibiting proliferation activity of an ovarian cancer SKOV3 cell; an MTT result shows that distribution of a cell cycle is affected by the Chenopodolin; tumor cells are retarded at a G0 / G1 stage; meanwhile, the Chenopodolin can be combined with a tyrosine kinase phosphorylation ATP binding site of an EGFR / HER2 acceptor to inhibit phosphorylation of tyrosine kinase, so that cell apoptosis is induced by down-regulating expression of HER2 and P-HER2 protein; and the Chenopodolin can be further researched and developed into the medicines for treating the ovarian cancer.
Owner:吴正锋

Application of long-chain non-coding RNA LINC00205 in preparation of reagent for diagnosing ovarian cancer or medicament for treating ovarian cancer

MEHP treatment significantly increases the migration and invasion ability of tumor cells, and the results show that MEHP can induce epithelial-mesenchymal transition of ovarian cancer cells. SKOV3 cells treated by the MEHP with a concentration of 500nM are subjected to transcription group sequencing by a high-throughput sequencing method, the sequencing result is analyzed, and 39 confirmed long-chain non-coding RNAs are screened out; and in the differentially-expressed 39 lnc RNAs, the results show that linc00205 plays an important role in the ovarian cancer cell migration, invasion ability improvement and epithelial-mesenchymal transition induced by the MEHP.
Owner:ZHEJIANG UNIV

Application of timosaponin I in preparation of medicine for resisting human ovarian cancer

The invention provides application of timosaponin I in preparation of anti-human ovarian cancer drugs, and belongs to the technical field of new medical application of the timosaponin I. The molecular formula of the timosaponin I is C39H66O14, and the chemical structural formula of the timosaponin I is shown in the specification. The timosaponin I can effectively inhibit expression of mRNA of SHH signal channel related target genes and protein GLI1 and SUFU in human ovarian cancer cells SKOV3; the timosaponin I can effectively inhibit proliferation, epithelial-mesenchymal transition (EMT), migration and invasion of SKOV3 cells, and it is indicated that the timosaponin I is expected to be developed into an effective component of the medicine for resisting the human ovarian cancer. In addition, the medicine can be prepared into different preparation forms according to the requirements of patients, is convenient for the patients to take, and has better development and application prospects.
Owner:NANJING MEDICAL UNIV

Medical application of 7-aromadendrene-6-ketone or 4-aromadendrene in field of gynaecology

The invention discloses medical application of 7-aromadendrene-6-ketone or 4-aromadendrene in the field of gynaecology. The invention discovers that gweicurculactone, isorupestonic acid, 7-aromadendrene-6-ketone and 4-aromadendrene have an excellent proliferation inhibition effect on human ovarian cancer SKOV3 cells and human cervical cancer Hela cells; despite that ledene is a dehydrated productof ledol in chemical structure, and has a relatively similar chemical structure, ledene shows great difference in the proliferation inhibition activity on the human ovarian cancer SKOV3 cells and human cervical cancer Hela cells, wherein the ledene realizes an obvious proliferation inhibition effect on the human cervical cancer Hela cells but an unapparent proliferation inhibition effect on the human ovarian cancer SKOV3 cells, while the ledol realizes an obvious proliferation inhibition effect on the human ovarian cancer SKOV3 cells but an unapparent proliferation inhibition effect on the human cervical cancer Hela cells. The ledene, the ledol, the gweicurculactone, the isorupestonic acid, the 7-aromadendrene-6-ketone and the 4-aromadendrene all can be used for treating gynecological tumors.
Owner:淮安培元基因科技有限公司

Benzylamino-substituted fatty acid derivative as well as preparation method and application thereof

The invention belongs to the technical field of medicines, and particularly relates to a benzylamino-substituted fatty acid derivative as well as a preparation method and application thereof. The benzylamino-substituted fatty acid derivative disclosed by the invention is (R, E) 5-(benzyloxy)-2-hexylhexadecane-2-olefine acid, and is obtained by synthesizing a raw material 3-hexyltetrahydro-4-hydroxy-6-undecyl-2H-pyran-2-ketone, and the raw material has the following structural formula shown in the description. Under the test concentration of 40 [mu] M, the inhibition rate of the prepared derivative on pancreatic cancer PANC-1, head and neck cancer TCA8113 and breast cancer MCF-7 cells is up to 80% or above, the inhibition rate on liver cancer HepG2, nasopharynx cancer CNE-2, kidney cancer A498 and bladder cancer T24 cells is 70-80%, the inhibition activity on ovarian cancer SKOV3 cells can reach 65.8%, and the derivative can be applied to preparation of antitumor drugs.
Owner:ZHONGSHAN WANHAN PHARM CO LTD

Wenwang Yibi Extract and Its Application in the Preparation of Anticancer Drugs

The invention provides a herba balanophorae involucratae extract. The extract is an extract of an alcohol-soluble substance position obtained after herba balanophorae involucratae is subjected to water extraction and then is subjected to alcohol precipitation treatment or an extract of an ethyl-acetate position obtained after a supernatant solution, which is obtained after the herba balanophorae involucratae is subjected to the water extraction and then is subjected to the alcohol precipitation treatment, is abstracted through ethyl acetate or an extract of a water-extracted and alcohol-precipitated position obtained after a precipitate, which is obtained after the herba balanophorae involucratae is subjected to the water extraction and then is subjected to the alcohol precipitation treatment, is washed through alcohol and dried. According to the herba-balanophorae-involucratae extract, the herba-balanophorae-involucratae extract is applied to the preparation of a medicine for treatingan ovarian cancer and shown by an experiment, the herba-balanophorae-involucratae extract can be used for inhibiting the growth of A2780 and SKOV3 cells for the ovarian cancer in vitro in a dose-dependent manner, can be used for obviously inhibiting the growth of an A2780 nude-mice transplantation tumor in vivo and has a better effect.
Owner:CHINA THREE GORGES UNIV

Compound with chemotherapy and phototherapy anti-tumor effects as well as preparation method and application of compound

The invention discloses a compound with chemotherapy and phototherapy anti-tumor effects. The chemical name of the compound is monochloro-chloro-(9-anthracene-N4-methylthiosemicarbazide)-pentamethylcyclopentadienyl rhodium (III), and the structural formula of the compound is shown in the description. The compound has good inhibitory effects on human prostate cancer PC3 cells, human ovarian cancerSKOV3 cells, and high blood pressure, and can be used for preparing drugs for treating prostate cancer, ovarian cancer and hypertension.
Owner:GUANGXI UNIV OF CHINESE MEDICINE
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