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Medical application of isorupestonic acid for treating gynecological tumors

A technology of gynecological tumor and artemitonic acid, applied in the field of medicine, can solve problems such as death and evolution

Inactive Publication Date: 2019-02-22
淮安培元基因科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although complete remission can be achieved after initial surgery and chemotherapy, most patients with advanced disease will still relapse within 2 to 3 years, and eventually become resistant to chemotherapy and die

Method used

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  • Medical application of isorupestonic acid for treating gynecological tumors
  • Medical application of isorupestonic acid for treating gynecological tumors

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Experimental program
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Embodiment Construction

[0015] The substantive content of the present invention will be described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0016] 1. Experimental materials

[0017] The structural formula of the test compound is as figure 1 As shown, including trumpetene, trumpet alcohol, cinnamonolide, isoartemisinic acid, 7-armentene-6-one and 4-arrene, the standard products are purchased or self-made, and the purity is ≥98%.

[0018] Human ovarian cancer SKOV3 cells and human cervical cancer Hela cells were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences.

[0019] DMEM / F12 medium, high-glucose DMEM medium, and fetal bovine serum were purchased from GIBCO.

[0020] Tetramethylazolazolium blue (MTT) and DMSO were purchased from SIGMA.

[0021] Double antibody solution and trypsin were purchased from Hyclone Company, USA.

[0022] 2. Experimental method

[0023] 1. Cell culture

[002...

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Abstract

The invention discloses a medical application of isorupestonic acid for treating gynecological tumors. The medical application discovers that Gui curcumalactone, isorupestonic acid, 7-aromadendrene-6-ketone and 4-aromadendrene have excellent proliferation-inhibiting effect for human ovarian cancer SKOV3 cells and human cervical cancer Hela cells; ledene is a dewatered product of ledol from chemical structure, the chemical structures are more similar, but the difference of the human ovarian cancer SKOV3 cells and the human cervical cancer Hela cells is larger in proliferation-inhibiting activity, wherein the ledene has obvious proliferation-inhibiting effect for the human cervical cancer Hela cells, and has no obvious proliferation-inhibiting effect for the human ovarian cancer SKOV3 cells,but the ledol has obvious proliferation-inhibiting effect for the human ovarian cancer SKOV3 cells, and has no obvious proliferation-inhibiting effect for the human cervical cancer Hela cells. All the ledene, the ledol, the Gui curcumalactone, the isorupestonic acid, the 7-aromadendrene-6-ketone and the 4-aromadendrene can be used for treating the gynecological tumors.

Description

technical field [0001] The invention belongs to the field of medicine, relates to gynecology, and specifically relates to the medical use of isoartemisinic acid for treating gynecological tumors. Background technique [0002] Gynecological tumor is a common and frequently-occurring disease that seriously threatens women's health, and can be divided into benign and malignant. Common gynecological benign tumors include ovarian benign tumors, ovarian tumor-like lesions (simple ovarian cysts and ovarian chocolate cysts, etc.), pelvic inflammatory masses, adenomyosis, and uterine fibroids. The specific methods include surgery, drugs, intervention, etc., among which surgery is the main treatment method, but its damage to ovarian function has been in recent years. has been gradually paid attention to. Traditional Chinese medicine treatment of gynecological benign tumors can control and reduce the tumor size for patients who do not meet the surgical indications, so as to avoid sur...

Claims

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Application Information

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IPC IPC(8): A61K31/015A61K31/045A61K31/365A61K31/19A61K31/122A61P35/00
CPCA61K31/015A61K31/045A61K31/122A61K31/19A61K31/365A61P35/00A61K2300/00
Inventor 张长林杨佳
Owner 淮安培元基因科技有限公司
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