37 results about "Sex Hormone Binding Protein" patented technology

There are provided methods for assaying biological specimens for steroids (androgens and estrogens), Sex Hormone-Binding Globulin (SHBG) and Albumin in order to calculate the free and bioavailable steroid concentration based on the laws of mass action and association constants predicated on the identification that one molar equivalent of SHBG contains two molar equivalents of steroid binding sites.

The present invention relates to antisense oligonucleotides that modulate the expression of and / or function of Sex Hormone Binding Globulia (SHBG), in particular, by targeting natural antisense polynucleotides of Sex Hormone Binding Globulin (SHBG). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of SHBG.

The invention relates to a Chinese medicinal composition for a kidney-yang deficiency and phlegm-retention type polycystic ovary syndrome. The Chinese medicinal composition comprises the following medicinal materials of epimedium, caladium, semen psoraleae, sliced deerhorn, sea horse, tortoise plastron and the like, does not contain rhubarb and Chinese angelica. The Chinese medicinal composition can reduce the level of androgens and androgen receptors of polycystic ovanian syndrome (PCOS) patients, improve the level of sex hormone binding globulin, reduce the level of free testosterone, improve the level of in-vivo estrogens, improve the growth and development of follicles and improve the ovulation rate and pregnancy rate of patients.

The invention discloses a method for using serum SHBG (Sex hormone-binding globulin) as serum markers of pulmonary tuberculosis patients and an application thereof. The expression levels of the serum SHBG in serum of the smear negative pulmonary tuberculosis patients, the smear positive pulmonary tuberculosis patients and the multi-drug resistant pulmonary tuberculosis patients are obviously increased, detection can be carried out with the iTRAQ and MALDI-TOF / MS combined technology, mass spectrometric detection shows that the expression levels of five peptide fragments of the SHBG in the serum of the smear negative pulmonary tuberculosis patients, the smear positive pulmonary tuberculosis patients and the multi-drug resistant pulmonary tuberculosis patients are obviously higher than the expression levels in the serum of pneumonia patients and the normal, and ELISA and immunohistochemistry also verify that the SHBG is highly expressed in the serum and tissues of the pulmonary tuberculosis patients. The method and the application are suitable for auxiliary detection of pulmonary tuberculosis serum, pathogenesis researching and tuberculosis resisting drug development.

The present invention is directed to a method of identifying a patient having heart failure as likely to respond to a therapy comprising a statin. The method is based on measuring the level of at least one marker selected from GDF-15 (Growth Differentiation Factor 15), Urea, SHBG (Sex Hormone-Binding Globulin), Uric acid, PLGF (Placental Growth Factor), IL-6 (Interleukin-6), Transferrin, a cardiac Troponin, sFlt-1 (Soluble fms-like tyrosine kinase-1), Prealbumin, Ferritin, Osteopontin, sST2 (soluble ST2), and hsCRP (high sensitivity C-reactive protein) in a sample from a patient. Further envisaged is a method of predicting the risk of a patient to suffer from death or hospitalization, wherein said patient has heart failure and undergoes a therapy comprising a statin. The method is also based on the measurement of the level of at least one of the aforementioned markers.

A method for predicting the degree of weight loss in male subject attainable by applying one or more dietary interventions to a subject, said method comprising determining the level of one or more biomarkers in one or more samples obtained from the subject, wherein the biomarkers are selected from sex hormone-binding globulin, beta-2-microglobulin and serum paraoxonase / arylesterase.

The invention provides a pharmaceutical composition for treating polycystic ovary syndrome (PCOS). The pharmaceutical composition consists of a traditional Chinese medicine composition and chemical drugs, wherein the traditional Chinese medicine composition comprises the medicinal materials such as anemarrhena, fritillary bulb, tortoise plastron, fleece-flower root, lilyturf root, hippocampus andthe like; and the chemical drugs comprise one or more compound molecules of dexamethasone, spirolactone, ethinyloestradiol, estradiol valerate, conjugated estrogen and pharmaceutically acceptable salt. The pharmaceutical composition has the advantages of reducing the level of androgens and androgen receptors of patients suffering from PCOS, improving the level of sex hormone-binding globulin (SHBG), lowering the level of free testosterone (F-TESTO), further raising the level of in-vivo estrogens, improving growth and development of follicles and increasing ovulation rate and pregnancy rate ofthe patients.

The present invention relates to antisense oligonucleotides that modulate the expression of and / or function of Sex Hormone Binding Globulin (SHBG), in particular, by targeting natural antisense polynucleotides of Sex Hormone Binding Globulin (SHBG). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of SHBG.

The invention discloses a preservation solution of sex hormone-binding globulin, a preparation method thereof, a detection agent and a kit for detecting sex hormone-binding globulin, and belongs to the technical field of in vitro diagnostic reagents. The preservation solution includes a buffer, sex hormones, IIA and / or IIB family ions, osmotic agents, animal serum, surfactants and protein stabilizers, wherein the concentration of the sex hormones in the preservation solution is 1- 10 μM, the concentration of the group IIA and / or group IIB ions in the preservation solution is 10-60 mM. Both the detection agent and the kit contain the preservation solution of the present invention. The preservation solution of the sex hormone binding globulin of the present invention can keep the dimer structure and biological activity of the sex hormone binding globulin dissolved in the preservation solution stable. The detection agent and kit can ensure the detection accuracy of sex hormone binding globulin, and are convenient and fast.