35 results about "Quinone Reductases" patented technology

An active agent capable of reducing quinone reductase 2 activity, for use in improvement of cognition in a subject is provided. Such an active agent may be a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 or an inhibitor of quinone reductase 2 activity. A vector comprising a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 and a pharmaceutical composition comprising an active agent capable of reducing quinone reductase 2 activity or said vector are provided as well.

A supplement including a blend of turmeric, quercetin and rosemary, or holy basil, wasabi, and broccoli seed extract which are present in a balanced and predetermined ratio, and which stimulate the Antioxidant Response Element (ARE), Quinone Reductase, and / or induce related gene expression, for example, heme oxygenase-1 (HMOX-1) expression. The blend of ingredients can be formed as or in a dietary supplement adapted for administration to a subject. The dietary supplement can be formulated so that the turmeric, quercetin and rosemary are present in a predetermined ratio of 1:3:5, or holy basil, wasabi, and broccoli seed extract in a predetermined ratio of 1:1:0.2. Additional ingredients can be included in the supplement. The supplement can synergistically affect natural antioxidant response pathways within cells of a subject to whom the supplement is administered. A related method of use is also provided.

The invention discloses the application of effective parts of common andrographis herbs in preparing medicaments with a cancer chemoprevention function. Because effective parts of common andrographis herbs can induce expression of quinone reductase so as to achieve a cancer chemoprevention effect, the effective part of common andrographis herbs can be used for preparing medicaments with a cancer chemoprevention function. According to the invention, effective parts of common andrographis herbs are prepared into a tablet form, and pharmacological experiments prove that the prepared tablet has a strong quinone reductase inducing activity, therefore, the tablet can achieve a better cancer chemoprevention effect. The method for preparing effective parts of common andrographis herbs comprises the following steps: carrying out extraction on all herbs or leaves of andrographis paniculata by using an extraction solvent so as to obtain an extracting solution; concentrating the extracting solution, adding water into the concentrated extracting solution to dissolve, carrying out extraction on the dissolved solution by using a extraction solvent, collecting extract liquor, and then concentrating the extract liquor so as to obtain the effective parts of common andrographis herbs with stable properties and a high pharmacological activity; and the method is simple in preparation process, easy to implement, and easy to operate and control, therefore, the method has extremely broad application prospects.

The present invention relates to a pharmaceutical composition for preventing cancer or improving liver function, containing Youngia denticulata extract, a fraction thereof, or one or more compounds as an active ingredient selected from a group consisting of chlorogenic acid, 3,5-di-O-caffeoylquinic acid, Youngiaside A, Youngiaside B, and Youngiaside C which are isolated therefrom. The Youngia denticulata extract, a fraction thereof, or a compound isolated therefrom according to the present invention enhances activation of detoxifying enzymes in the liver, including quinone reductase(QR) of a marker enzyme for preventing cancer and an antioxidant response element(ARE) of an antioxidant responsive factor. The extract, fraction, or compound is not cytotoxic as well protects the liver from liver injury induced by ethanol or acetaminophen. Therefore, the composition according to the present invention can be useful in medicinal products and health foods for preventing cancer or improving liver function.

The invention discloses a compound having quinone reductase induced activity, which has a structure shown in Formula I. The compound has quinone reductase induced activity and can be used for preventing cancer. The invention also discloses a preparation method of the compound having quinone reductase induced activity, which is simple, reliable, easy to implement, high in operability and favorable in controllability. Formula I is shown in the specification.

The invention belongs to the technical filed of medicines, and relates to the preparation of three new hopane-type triterpenes and applications thereof. The new hopane-type triterpene saponins have the following structure shown in the specification. The new hopane-type triterpene compounds have quinone reductase induced activity, and can be used for development and application of anti-tumor drugs and tumor chemoprevention drugs.

An active agent capable of reducing quinone reductase 2 activity is for use in improvement of cognition in a subject. Such an active agent can be a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 or an inhibitor of quinone reductase 2 activity. A pharmaceutical composition can contain the active agent or a vector containing the active agent.

The invention discloses a compound for preventing cancers. The structure of the compound is shown in the formula II, wherein R represents Alpha-OH or Beta-OH. The compound has the quinone reductase inducing activity and can be used for preventing cancers. The invention further discloses a preparation method of the compound for preventing cancers. The method is simple, reliable, easy to implement, strong in operability and good in controllability.

The present invention provides transgenic plants transformed with exogenous nucleic acid encoding a Dunaliella salt-inducible or salt-responsive protein selected from the group consisting of eukaryotic initiation factor 3 (eIF3) subunit, NADPH dependent quinone reductase (QOR), aldo-keto reductase (AKR), bifunctional aspartate kinase-homoserine reductase (AK-HSD) and mitochondrial import membrane translocase subunit (TIM9), or a fragment, homolog or variant thereof. The transgenic plants have increased tolerance to salt as compared to corresponding non-transgenic plants. The present invention further provides nucleic acids, constructs and vectors encoding the Dunaliella salt-inducible or otherwise salt-responsive proteins, and to a method of producing transgenic plants having an increased tolerance to salt, a method of modifying plant capacity to survive salt shock, and a method of modifying plant recovery after exposure to salt stress, by introducing the nucleic acids, constructs and / or vectors into one or more cells of the plant.