43 results about "Oral Cavity Squamous Cell Carcinoma" patented technology

Provides an auxiliary marker for disease identification consisting of decanoylcarnitine, cysteine ​​and bile acids. The present invention also provides a method for constructing a disease identification model, which includes: step 1, obtaining a training case set, and the subjects in the training case set include oral lichen planus patients and oral squamous cell carcinoma patients. In step 2, the serum sample of the subject is collected, and the serum sample is subjected to ultra-high performance liquid chromatography-quadrupole / electrostatic field orbitrap tandem high-resolution mass spectrometry analysis to obtain oral lichen planus and oral squamous cell carcinoma. Multiple differential metabolites; step 3, using variable weight importance ranking and receiver operating characteristic curves to determine decanoylcarnitine, cysteine ​​and bile acids from multiple differential metabolites as a disease discrimination model. The invention provides a disease identification model, which can identify and distinguish oral lichen planus and oral squamous cell carcinoma at an early stage, and has the advantages of minimally invasive and high accuracy.

The invention discloses a deep learning method for identifying oral squamous cell carcinoma based on visual features, including: 1) establishing a development set and a test set; 2) constructing data training samples; 3) training a target detection network model; 4) passing the The target detection model performs batch initial positioning on the oral photos of the development set, and constructs classification network data samples using the positioned image areas; 5) expands the classification network data samples; 6) DenseNet is used as the backbone network of the classification network, and DenseNet is improved to make the model Focus more on difficult misclassified samples; 7) train the classification network on the expanded samples to obtain an oral squamous cell carcinoma classification network; 8) test the classification network; 9) apply the classification network to classify oral photos. The method has high sensitivity and good specificity for detecting oral squamous cell carcinoma from oral cavity photographs, and is suitable for detection and screening of various oral squamous cell carcinomas.

The invention provides a reagent kit for diagnosing oral squamous cell carcinoma. The reagent kit comprises specific antibodies for detecting HOXA10, specific antibodies for detecting HOXA11, specific antibodies for detecting HOXC6 or compositions with more than one or two optional specific antibodies for detecting the expression quantities of HOXC8. The reagent kit has the advantages that sequencing results for mRNA [messenger RNA (ribonucleic acid)] of the oral squamous cell carcinoma and normal oral tissues in TCGA (the cancer genome atlas) databases are statistically analyzed, data of 32 cases of normal oral tissues and 341 cases of oral squamous cell carcinoma tissues are incorporated, obvious difference of expression of partial genes in HOX families in the oral squamous cell carcinoma and the normal tissues is discovered, and accordingly the reagent kit is suitable to be applied to diagnosing the oral squamous cell carcinoma; expression of genes in the HOX families is detected in oral squamous cell carcinoma tissue pathological sections by the aid of immunohistochemical processes, and accordingly positive expression of the genes in the oral squamous cell carcinoma and application values of the genes in diagnosis can be determined.