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Biomarkers and their application in oral squamous cell carcinoma

A technology for squamous cell carcinoma and oral cavity, which is applied in the field of protein markers, can solve the problems of not finding high-sensitivity and specificity biomarkers

Active Publication Date: 2016-03-23
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since 2007, a number of molecular diagnostic / molecular typing commercial kits for solid tumors (including prostate cancer, breast cancer, etc.) In the field of translational medicine, there are no effective commercialized molecular diagnostic products, and the individualized diagnosis and treatment of oral oropharyngeal squamous cell carcinoma urgently requires in-depth research on new key genes
[0005] There is no biomarker with high sensitivity and specificity that can be used to predict cervical lymph node metastasis of oral oropharyngeal squamous cell carcinoma in the prior art

Method used

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  • Biomarkers and their application in oral squamous cell carcinoma
  • Biomarkers and their application in oral squamous cell carcinoma
  • Biomarkers and their application in oral squamous cell carcinoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1, GPD1L and HIF1α protein expression and its correlation analysis and verification with cervical lymph node metastasis

[0040] (1) Selection of clinical cases

[0041] Randomly selected 125 patients with primary oral squamous cell carcinoma who were hospitalized in the Department of Oral and Maxillofacial Surgery of Peking University Hospital of Stomatology from June 1993 to May 2010 and received neck dissection at the same time. ., 2010), as a neck dissection group, for the analysis of potential biomarkers related to cervical lymph node metastasis.

[0042] In addition, 106 cases of primary early oral squamous cell carcinoma of the neck "sitting and watching" were randomly selected as the verification group, and the delayed cervical lymph node metastasis rate of patients in this group was observed. The value of the molecular markers identified in the "Group" in guiding the treatment of early oral squamous cell carcinoma of the neck.

[0043] The cut-off dat...

Embodiment 2

[0102] Example 2. The synergistic effect of GPD1L and HIF1α protein expression is an independent predictor for predicting cervical metastasis of oral squamous cell carcinoma

[0103] In this example, the data of 231 cases of patients in the two groups in Example 1 were first summarized, and single factor survival analysis was used to screen the patients with cervical metastasis of oral squamous cell carcinoma (cervical metastasis at the same time in the neck clearing group + delayed cervical metastasis in the verification group). Alternative factors include age, gender, site of disease, T stage, pathological grade, smoking and alcohol history, lymph node status, histological high-risk factors, and the synergistic effect of GPD1L and HIF1α expression. The results showed that including preoperative T stage (P<0.001), pathological grade (P=0.001), drinking history (P=0.015), histological risk factors (P=0.009), growth pattern (P=0.005) and GPD1L and HIF1α Six factors including th...

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Abstract

The invention provides a biological marker of oral cavity oropharynx squamous-cell carcinoma and application of the biological marker. The biological marker is GPD1L and / or HIF1 alpha, and especially a combination of the GPD1L and the alpha. According to the invention, by detecting expression levels of the GPD1L and / or the HIF1 alpha, oral cavity oropharynx squamous-cell carcinoma auxiliary diagnosis, oral cavity oropharynx squamous-cell carcinoma patient prognosis, and / or prognosis cervical lymph node metastasis prediction can be performed.

Description

technical field [0001] The invention belongs to the field of biotechnology, and specifically relates to a protein marker related to the prediction of cervical lymph node metastasis of oral squamous cell carcinoma and / or oropharyngeal squamous cell carcinoma and its application. Background technique [0002] In my country, more than 90% of oral oropharyngeal cancers are squamous cell carcinomas, and the epidemiological statistics have gradually increased in recent years. Because it is located in an important position in the respiratory tract and digestive tract, it plays an important role in body language, eating, and breathing. Severe lesions can cause disfigurement, swallowing, chewing, pronunciation and other dysfunctions, affecting the quality of life of patients, and even endangering their lives. The diagnosis and treatment status of oral oropharyngeal squamous cell carcinoma patients are as follows: ①Surgery-based treatment is the only curative method, and the tumor is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/57407G01N2800/52G01N2800/7028
Inventor 冯芝恩郭传瑸
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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