Construction method of disease identification model, marker and application thereof

Abstract

The invention provides an auxiliary marker for identifying diseases. The auxiliary marker consists of decanoyl carnitine, cysteine and bile acid. The invention also provides a construction method of adisease identification model, which comprises the following steps of: firstly, acquiring a training case set, the subjects in the training case set comprising oral lichen planus disease subjects andoral squamous cell carcinoma disease subjects; secondly, collecting serum samples of the subjects, and carrying out ultra-high performance liquid chromatography quadrupole / electrostatic field orbitraptandem high-resolution mass spectrometry analysis on the serum samples to obtain a plurality of differential metabolites of oral lichen planus and oral squamous cell carcinoma; and thirdly, determining decanoyl carnitine, cysteine and bile acid from the plurality of differential metabolites as a disease identification model by utilizing variable weight importance sorting and a subject working characteristic curve. The invention provides a disease identification model which can be used for identifying and distinguishing oral lichen planus and oral squamous cell carcinoma in the early stage andhas the advantages of being minimally invasive and high in accuracy.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for constructing a disease identification model, markers and applications thereof, in particular to a method for establishing a model for identification of oral lichen planus and oral squamous cell carcinoma, markers and applications. Background technique [0002] Oral lichen planus (OLP) is a common oral mucosal disease with a high incidence in oral mucosal diseases, with certain gender and age distribution characteristics, most commonly affecting middle-aged women. Its lesions progress slowly and can cause great pain, and these lesions rarely resolve spontaneously. Oral mucosal lesions of OLP often occur symmetrically, and can occur in any part of the lips, cheeks, tongue, floor of the mouth, etc., and are most common in the cheeks, mostly with white or off-white patterns, which enlarge and combine to form a reticular, Circular and dendritic patterns can also form wh...

AI Technical Summary

Problems solved by technology

[0004] Currently, it is difficult to distinguish OSCC from OLP, so in the early diagnosis of OSCC and the prediction of tumor invasion, better methods are urgently needed to improve diagnosis and treatment

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