Construction methods, markers and applications of disease identification models

Abstract

Provides an auxiliary marker for disease identification consisting of decanoylcarnitine, cysteine ​​and bile acids. The present invention also provides a method for constructing a disease identification model, which includes: step 1, obtaining a training case set, and the subjects in the training case set include oral lichen planus patients and oral squamous cell carcinoma patients. In step 2, the serum sample of the subject is collected, and the serum sample is subjected to ultra-high performance liquid chromatography-quadrupole / electrostatic field orbitrap tandem high-resolution mass spectrometry analysis to obtain oral lichen planus and oral squamous cell carcinoma. Multiple differential metabolites; step 3, using variable weight importance ranking and receiver operating characteristic curves to determine decanoylcarnitine, cysteine ​​and bile acids from multiple differential metabolites as a disease discrimination model. The invention provides a disease identification model, which can identify and distinguish oral lichen planus and oral squamous cell carcinoma at an early stage, and has the advantages of minimally invasive and high accuracy.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for constructing a disease identification model, markers and applications thereof, in particular to a method for establishing a model for identification of oral lichen planus and oral squamous cell carcinoma, markers and applications. Background technique [0002] Oral lichen planus (OLP) is a common oral mucosal disease with a high incidence in oral mucosal diseases, with certain gender and age distribution characteristics, most commonly affecting middle-aged women. Its lesions progress slowly and can cause great pain, and these lesions rarely resolve spontaneously. Oral mucosal lesions of OLP often occur symmetrically, and can occur in any part of the lips, cheeks, tongue, floor of the mouth, etc., and are most common in the cheeks, mostly with white or off-white patterns, which enlarge and combine to form a reticular, Circular and dendritic patterns can also form wh...

AI Technical Summary

Problems solved by technology

[0004] Currently, it is difficult to distinguish OSCC from OLP, so in the early diagnosis of OSCC and the prediction of tumor invasion, better methods are urgently needed to improve diagnosis and treatment

Images