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Application of Cranemenine in Biomedicine

A technology of Crane and medicine, which is applied in the field of medicine and can solve problems such as reports on the anti-tumor activity of Crane.

Active Publication Date: 2020-12-01
北京麦迪海药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is no report on the anti-tumor activity of citrusine

Method used

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  • Application of Cranemenine in Biomedicine
  • Application of Cranemenine in Biomedicine

Examples

Experimental program
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Embodiment Construction

[0017] The substantive content of the present invention will be specifically introduced below in conjunction with the embodiments. Due to space reasons, the description of the experimental process cannot be done in great detail. All the parts not described in detail in the experiment are routine operations well known to those skilled in the art.

[0018] 1. Experimental materials

[0019] Human lung adenocarcinoma cell H2228, human bladder cancer cell T24, human liver cancer cell SMMC-7721, human breast cancer cell MCF-7, human gastric cancer cell MGC-803, and human oral squamous cell carcinoma Tca8113 were treated with 10% fetal bovine serum The RPMI-1640 culture is based on 37 ℃, 5% CO 2 Cells were routinely cultured in a cell incubator, and cells in logarithmic growth phase were used in experiments.

[0020] Cranemenine is self-made with a purity of >98%.

[0021] RPMI-1640 medium and fetal bovine serum were purchased from Gibco.

[0022] 2. Experimental method

[0023]...

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PUM

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Abstract

The invention discloses application of argyreia aceta alkali in biological medicines. The whole herb of argyreia aceta has medicinal value, and argyreia aceta is widely distributed in many places of Guangxi, such as Guigang, Yulin, Fangcheng Gang and Wuming, and is used as a traditional Chinese medicine for treating acute and chronic bronchitis, tuberculosis, liver cirrhosis, nephritis edema, sores and furuncles, acute mastitis, skin eczema, traumatic bleeding and other symptoms. The argyreia aceta alkali is a chemical component separated from argyreia aceta. According to the invention, through the tests for the proliferation inhibition effect of the argyreia aceta alkali on human lung adenocarcinoma cell H2228, human bladder cancer cell T24, human hepatoma carcinoma cell SMMC-7721, humanbreast cancer cell MCF-7, human gastric carcinoma cell MGC-803 and human oral squamous cell carcinoma Tca8113, the argyreia aceta alkali is found to have an excellent inhibiting effect on human bladder cancer cell T24 and human oral squamous cell carcinoma Tca8113 and has no obvious inhibiting effect on other tested tumor cells, so that the argyreia aceta alkali can be used for preparing drugs fortreating bladder cancer or oral squamous cell carcinoma.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the new application of known natural products, in particular to the new application of scutrine. Background technique [0002] The whole herb of Argyreia aceta is used for medicinal purposes. According to the "Guangxi Medicinal Plant List", it is distributed in Guigang, Yulin, Fangchenggang, Wuming and other places in Guangxi. Traditional Chinese medicine is used to treat acute and chronic bronchitis, tuberculosis, liver cirrhosis, nephritis and edema , boils, mastitis, skin eczema, traumatic bleeding embolism. Siberine is a chemical component isolated from Siberian vine (Lu Rumei et al., A new alkaloid in Siberian vine, Chinese herbal medicine volume 49, issue 15, August 2018). [0003] So far, there has been no report on the anti-tumor activity of citrusine. Contents of the invention [0004] The purpose of the present invention is to provide a new application of siltrine. [0005] R...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/706A61P35/00
CPCA61K31/706A61P35/00
Inventor 刘华平李月群金荣
Owner 北京麦迪海药业有限责任公司
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