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44 results about "Nerve bundle" patented technology

Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditions

A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.
Owner:MEDTRONIC INC

Method and apparatus for selective control of nerve fibers

A method and apparatus particularly useful for pain control by selectively blocking the propagation of body-generated action potentials travelling through a nerve bundle by using a tripolar electrode device to generate unidirectional action potentials to serve as collision blocks with the body-generated action potentials representing pain sensations in the small-diameter sensory fibers. In the described preferred embodiments there are a plurality of electrode devices spaced along the length of the nerve bundle which are sequentially actuated with delays corresponding to the velocity of propagation of the body-generated action potentials through the large-diameter fibers to produce a "green wave" effect which minimizes undesired anodal blocking of the large-diameter fibers while maximizing the collision blocking of the small-diameter fibers.
Owner:MEDTRONIC INC

Surgical forceps

This application presents a bifurcated, optimally-angled surgical forceps. In one example, this surgical forceps may enable a more natural maneuver for initial clamping of the vas deferens through the scrotal skin. This may be more comfortable for users and easier to maintain, and may provide greater tactile surface contact between the thumb and vas deferens. This device also may provide the surgeon with an entire segment of vas deferens upon which the vasectomy may be performed, thus reducing the need for frequent repositioning of instruments. The device may also be applied to other surgical procedures that may benefit from the features of the device and where a section of a tubular anatomical structure may need clamping at two points along its length. Examples include blood and lymphatic vessels, ducts of the digestive system, and large nerves or nerve bundles.
Owner:ALFRED E MANN INST FOR BIOMEDICAL ENG AT THE UNIV OF SOUTHERN CALIFORNIA

Digital stereotaxic manipulator with interfaces for use with computerized brain atlases

A system is disclosed that allows stereotaxic procedures being performed on lab animals to interact, on a “live” or “real-time” basis, with information that has been compiled in stereotaxic brain atlases. For example, during an invasive procedure, a researcher can see, on a cross-sectional brain map displayed on a full-sized computer monitor, the location and travel of an instrument tip, indicated by means such as a bright blinking cursor or icon. If desired, important brain structures (such as major nerve bundles) can been prominently labeled and / or colored, to clearly indicate their locations, and help the researcher ensure that they are avoided. This system can be provided by coupling a digital stereotaxic manipulator to a dedicated controller with touch-screen capability, and coupling the PLC processor to a computer having a monitor screen that is large enough to display a brain map with good resolution. Alternately, the digital stereotaxic manipulator can be coupled directly to a computer, via an interface card or other device.
Owner:SCOUTEN CHARLES W +2

Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditions

A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.
Owner:MEDTRONIC INC

Implantable electrostimulation limb movement function regulation device

The invention discloses an implantable electrostimulation limb movement function regulation device. A body surface detecting electrode is adopted to collect body surface myoelectric action potential signals during movement at a site corresponding to a healthy limb, the body surface myoelectric action potential signals are amplified and filtered by a signal processing circuit, pulse amplitude modulation technology is utilized to modulate the body surface myoelectric action potential signals onto high-frequency carriers, high-frequency signals after being modulated are applied onto an in-vitro coil to generate a high-frequency electromagnetic field, the in-vitro coil is coupled on a coil of an in-vivo implantable electrode to generate high-frequency voltage, stimulating voltage pulse is formed after amplitude detection, the stimulating voltage pulse is applied onto an in-vivo electrode contacting with a controlled nerve bundle, and action potential is excited in the nerve bundle so as to realize movement of a paralytic limb. The body surface electrode is pasted on the healthy limb to acquire movement related myoelectric signals, so that the device has the advantage of non-intrusion; the in-vivo implantable electrode is adopted for functional electrostimulation, so that the device has the advantages of low stimulation voltage, high control sensitivity and high selectivity.
Owner:NANJING SHENQIAO MEDICAL EQUIP

Nerve graft and nerve graft system using same

The invention provides a nerve graft and a nerve graft system using the same, and relates to the technical field of medical engineering. The nerve graft provided by the invention comprises a sensory nerve bundle passage, a moving nerve bundle passage and a mixed nerve bundle passage; all nerve bundle passages are matched with the nerve bundles of the corresponding sections of normal nerve, and are respectively filled with NGF (nerve growth factor), GDNF (glial cell-line derived neurotrophic factor), and NGF and GDNF. The nerve graft provided by the invention is matched with the nerve section to be restored in appearance; the inside nerve bundle passage trend is also precisely matched with the nerve bundle to be restored. Secondly, different nerve nutrition factors are respectively loaded in the nerve graft; the promotion and the direction guide can be performed for the nerve bundles with different functions; the matching rate of the nerve graft and the receptor nerve can be improved; the classified guidance on different nerve bundles can be realized; the nerve restoration effect is improved. In addition, the invention also provides the nerve graft system using the nerve graft so as to treat complicated nerve defect diseases and patients.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV +2

Identification of ligands that enable endocytosis, using in vivo manipulation of neuronal fibers

In vivo screening is used to identify and isolate ligands that drive endocytosis (internalisation) of molecules into animal cells. These ligands can transport passenger molecules (drug or diagnostic compounds, genetic vectors, etc.) into targeted classes of cells. A population of candidate ligands, such as a phage display or combinatorial library, is placed in a rat leg, in contact with a sciatic nerve bundle, and a ligature is tightened around the same nerve bundle at the hip. After a delay, to enable ligands that bind to endocytotic receptors on the nerve fibers to be internalised and transported within the fibers, fiber segments are harvested from the ligature site in the hip. Ligands that entered the harvested nerve segments can be isolated, sequenced, reproduced, etc. If desired, rats can be transformed to express human endocytotic receptors, to allow selection of ligands that will be transported into targeted human cells.
Owner:FERGUSON IAN +1

Method for reconstructing sensory nerve functions of amputation upper limbs and method for sensory nerve and artificial limb interfaces

InactiveCN105769396AFeeling resolvedThe technical method is simpleProsthesisSomesthetic areaPlexus brachialis
The invention discloses a method for reconstructing sensory nerve functions of amputation upper limbs and a method for reconstructing sensory nerve and artificial limb interfaces.The method for reconstructing the sensory nerve functions of the amputation upper limbs includes steps of separating sensory branches of various nerve bundles of remaining brachial plexus nerves of amputation patients and connecting the nerve sensory branches with sensory nerves in target sensory regions; adding different sensory sensors into nerve artificial limbs, timely transmitting external stimulation in contact with the artificial limbs to the target sensory regions of the limbs of the amputees by the aid of a stimulation input process and further transmitting the external stimulation in contact with the artificial limbs to sensory center regions of the brains of the amputees by the aid of the reconstructed target sensory regions of the limbs.The methods have the advantages that the brachial plexus nerves remained after the upper limbs of the amputation patients are amputated are connected into the selected target sensory regions, sensory innervation regions of the limbs can be reconstructed in the target sensory regions by the brachial plexus nerves, the limb sensory functions lost due to amputation can be reconstructed, and accordingly interfaces functions of remaining limb sensory and multifunctional nerve artificial limb sensory can be implemented.
Owner:ZUNYI MEDICAL UNIVERSITY

Extraneural cuff with flexible interconnects for stimulation and recording

An electrode system for neuromodulation and for recording of signals indicative of nerve activity is provided. The system can include a plurality of electrodes provided on a flexible, non-conductive substrate. The substrate can be rolled into a cuff for encircling a nerve bundle of a patient. The plurality of electrodes on the cuff can be interconnected using flexible conductors provided on the substrate. In one implementation, the electrodes can be interconnected using conductors that have spring-like configuration. Flexibility of the conductors allows the cuff to expand and contract with the nerve without causing excessive stress / strain at the nerve-cuff interface.
Owner:GALVANI BIOELECTRONICS LTD

Transvascular reshaping lead system

ActiveUS7979141B2Increase the usable areaReducing a threshold bias for stimulating the nerve trunkSpinal electrodesTransvascular endocardial electrodesLead systemBiological activation
A system for selective activation of a nerve trunk using a transvascular reshaping lead is provided. One aspect of this disclosure relates to a system for spreading nerve bundles in a nerve trunk. The system includes a lead adapted to be chronically implanted in a blood vessel proximate a nerve trunk, and having an expandable portion adapted to be expanded to reshape the blood vessel to an elongated shape and to reshape the nerve trunk into an elongated shape to spread nerve bundles of the nerve trunk. The system also includes a plurality of electrodes and an implantable device coupled to the lead, where an electrical signal is delivered from the implanted medical device to one of the plurality of electrodes to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk. Other aspects and embodiments are provided herein.
Owner:CARDIAC PACEMAKERS INC
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