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Making method of sandwich-type composite membrane stent

A sandwich-type, production method technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of directional drug release and low drug loading, and achieve the effect of preventing the formation of cerebrospinal fluid leakage and improving the effect of action

Inactive Publication Date: 2017-10-17
无锡市锡山人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] 2. Provide a new manufacturing method for the drug-loading system to solve the problems of directional drug release and low drug-loading capacity

Method used

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  • Making method of sandwich-type composite membrane stent
  • Making method of sandwich-type composite membrane stent
  • Making method of sandwich-type composite membrane stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 1) Make polylactic acid with a certain molecular weight (mass average molecular weight is 5000-1000000, preferably 5000-100000), dissolved in an organic solvent (organic solvents include 1,4-dioxane, acetone, chloroform / ethanol mixed Solvent, dichloromethane, tetrahydrofuran, and a mixed solvent of the above solvents), the concentration is 0.1-10 wt%, and the polylactic acid film is prepared by spin coating, drip coating, etc., as the outer sealing layer;

[0042] 2) Dissolving a chitosan film with a certain molecular weight (mass average molecular weight 5000-1000000, preferably 5000-100000) into an acidic aqueous solution (acids used include hydrochloric acid, acetic acid, nitric acid) at a concentration of 0.1-10 wt%, Prepare chitosan film by spin coating, drip coating, etc., as the inner controlled release layer and stem cell scaffold;

[0043] 3) The stem cell suspension is evenly immersed in the chitosan film in the previous step for cultivation by layer-by-layer ...

Embodiment 2

[0047] Compared with Example 1, the difference of Example 2 is that 5) each layer is adhered with medical bio-glue capable of penetrating nerve growth stimulating factor and stem cells.

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Abstract

The invention provides a manufacturing method of a sandwich-type composite membrane support, constructing a polylactic acid / bioactive glass / chitosan sandwich-type composite membrane carrier loaded with biologically active factors; comprising the following steps: Mesoporous bioactive glass with active factors, chitosan membrane loaded with seed cells as the outer sealing layer, sandwich layer and inner controlled release and stem cell scaffold layer; 2) The sandwich layer of bioactive glass loaded with bioactive factors is covered on the polymer On the lactic acid film, the chitosan membrane loaded with seed cells was covered on the bioactive glass layer to construct a sandwich composite membrane carrier. To solve the problem that a single nerve bundle that has been damaged (but not dead) cannot be repaired and treated by the existing technology; the existing drug-loading system cannot achieve the directional release of the drug and cannot guarantee the high concentration of the damaged local factors.

Description

technical field [0001] The invention relates to a manufacturing method of a sandwich type composite membrane support. Background technique [0002] Currently, the most common route of administration of nerve growth-promoting or nerve regenerative drugs is intravenous or intrathecal injection. There are also gel-binding active factor patches applied on the surface of the spinal cord, and L-polylysine-binding active factor as a scaffold implanted in the spinal cord to solve the problem of factors passing through the blood-brain barrier. [0003] Both drug delivery systems and stem cell bioscaffolds can be used to treat spinal cord injuries, but the combination of the two has not been seen so far. A similar combination has been used in the method and material of stem cell three-dimensional scaffold for bridging nerves, such as (a composite repair material and its scaffold for bridging defective nerves CN201510716279.8). However, the current treatment methods for bridging ne...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/20A61L27/10A61L27/18A61L27/54A61L27/22A61L27/38A61L27/50
CPCA61L27/20A61L27/10A61L27/18A61L27/227A61L27/3834A61L27/50A61L27/54A61L2300/412A61L2300/602A61L2430/32
Inventor 顾军纪立军宋晓丽冯晓军范健徐林
Owner 无锡市锡山人民医院
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