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Nerve graft and nerve graft system using same

A graft and nerve technology, which is applied in the field of nerve grafts and nerve graft systems using the same, can solve the problems of the structure of nerve grafts and the low degree of bionic microenvironment, and achieve the effects of improving the effect of nerve repair and improving the matching rate.

Active Publication Date: 2017-06-13
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of nerve graft, to alleviate the technical problem of the structure of the nerve graft and the microenvironment bionic degree existing in the prior art

Method used

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  • Nerve graft and nerve graft system using same
  • Nerve graft and nerve graft system using same
  • Nerve graft and nerve graft system using same

Examples

Experimental program
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Effect test

Embodiment 1

[0057] figure 2 The schematic diagram of the structure of the nerve graft provided in this embodiment, such as figure 2 As shown, the sensory nerve bundle channel 1 and the motor nerve bundle channel 2 converge to form a mixed nerve bundle channel 3, forming a "Y"-shaped structure. In this embodiment, the sensory nerve bundle channel tube 11 and the motor nerve bundle channel tube 21 and the tube wall thickness of the mixed nerve bundle channel tube 31 are both 0.23mm. The sensory nerve bundle channel filler 12 is composed of hydrogel and NGF, wherein the concentration of NGF is 85ng / mL; the motor nerve bundle channel filler 22 is composed of hydrogel and GDNF, wherein the concentration of GDNF is 80ng / mL; The beam channel filler 32 was composed of hydrogel and NGF and GDNF, wherein the concentrations of NGF and GDNF were 85 ng / mL and 80 ng / mL, respectively.

[0058] The preparation method of hydrogel in the present embodiment is:

[0059] Step (a), taking the peripheral ...

Embodiment 2

[0068] The nerve graft provided by embodiment 2 is an improvement on the basis of embodiment 1. Compared with embodiment 1, the nerve graft provided by embodiment 2 is also provided with sensory nerve bundle passage support 13, motor nerve bundle passage support 23 and Mixed nerve bundle channel holder 33, such as image 3 with Figure 4 as shown, image 3 Schematic diagram of the structure of the nerve graft provided in this embodiment; Figure 4 The cross-sectional schematic diagram of the motor nerve bundle channel 2 provided for the present embodiment; wherein image 3 with Figure 4 It only represents a schematic diagram of a nerve graft, and does not limit the number or diameter of a specific stent.

[0069] In the nerve graft provided in this embodiment, the sensory nerve bundle channel bracket 13, the motor nerve bundle channel bracket 23 and the mixed nerve bundle channel bracket are respectively arranged inside the sensory nerve bundle channel 1, the motor nerve ...

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Abstract

The invention provides a nerve graft and a nerve graft system using the same, and relates to the technical field of medical engineering. The nerve graft provided by the invention comprises a sensory nerve bundle passage, a moving nerve bundle passage and a mixed nerve bundle passage; all nerve bundle passages are matched with the nerve bundles of the corresponding sections of normal nerve, and are respectively filled with NGF (nerve growth factor), GDNF (glial cell-line derived neurotrophic factor), and NGF and GDNF. The nerve graft provided by the invention is matched with the nerve section to be restored in appearance; the inside nerve bundle passage trend is also precisely matched with the nerve bundle to be restored. Secondly, different nerve nutrition factors are respectively loaded in the nerve graft; the promotion and the direction guide can be performed for the nerve bundles with different functions; the matching rate of the nerve graft and the receptor nerve can be improved; the classified guidance on different nerve bundles can be realized; the nerve restoration effect is improved. In addition, the invention also provides the nerve graft system using the nerve graft so as to treat complicated nerve defect diseases and patients.

Description

technical field [0001] The invention relates to the technical field of medical engineering, in particular to a nerve graft and a nerve graft system using the same. Background technique [0002] The current clinical gold standard for repairing peripheral nerve defects is autologous nerve transplantation, that is, sacrificing other relatively insignificant nerves and using them as bridges to repair nerves with relatively important functions, which usually achieves better repair results. Other viable nerve grafts include nerve conduits and decellularized nerve allografts. Nerve conduits are hollow conduits made of degradable natural or synthetic materials, which can guide and support the regeneration of peripheral nerves, prevent nerves from growing laterally, limit the growth of myofibroblasts, and reduce scar formation. Another product category is decellularized nerve allografts. In 1998, Sondel et al. reported for the first time that the rat sciatic nerve was decellularize...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61L27/52A61L27/36A61L27/54A61L27/50
CPCA61L27/227A61L27/3675A61L27/3687A61L27/50A61L27/52A61L2300/252A61L2300/414A61L2430/32C08L89/00
Inventor 朱庆棠全大萍刘小林毛海泉顾立强戚剑郑灿镔邹剑龙刘晟曾晨光杨习锋王涛
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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