The invention discloses a safe transmission method of a physical layer in wireless communication, which is characterized by comprising the following steps of: a single-antenna desired user firstly transmits unencrypted request information to a multi-antenna base station; the base station receives the request information and estimates a signal path between the base station and the desired user with a frequency piloting sequence; the base station modulates bit to be transmitted into a constellation point symbol b (n) with a known phase position modulating mode, designs a fast-variable weighting coefficient, weights the constellation point symbol b (n) to be transmitted, and transmits the weighted symbol on selected Jrand antennas according appointed gross power; the desired user receives the weighted symbol, i.e. a weighting symbol, and decodes with a maximum likelihood method; and a wiretap user fast changes the weighting coefficient due to the process of the base station, can not decode with a blind equalization method, and can not decode with the maximum likelihood method, so that the method finally realizes the safe transmission.