47 results about "Low molecular weight protein" patented technology

The present invention relates to methods and compositions designed for treatment, management, or prevention of a hyperproliferative cell disease, particular cancer. The methods of the invention comprise the administration of an effective amount of a composition that targets cells expressing low molecular weight protein tyrosine kinase (“LMW-PTP”) in particular using moieties that bind an Eph family receptor tyrosine kinase, such as EphA2 or EphA4, and inhibits or reduces LMW-PTP expression and / or activity. In one embodiment, the method of the invention comprises administering to a subject a composition comprising an EphA2 or EphA4 targeting moiety attached to a delivery vehicle, and one or more agents that inhibit LMW-PTP expression and / or activity operatively associated with the delivery vehicle. In another embodiment, the method of the invention comprises administering to a subject a composition comprising a nucleic acid comprising a nucleotide sequence encoding an EphA2 or EphA4 targeting moiety and an agent that inhibits or reduces LMW-PTP expression and / or activity. In yet another embodiment, the method of the invention comprises administering to a subject a composition comprising an EphA2 or EphA4 targeting moiety and a nucleic acid comprising a nucleotide sequence encoding an agent that inhibits or reduces LMW-PTP expression and / or activity, where the nucleic acid is operatively associated with the delivery vehicle. Pharmaceutical compositions are also provided by the present invention.

A composition and method of use therefor that allows for permanent straightening or curl of human hair that is not irritating to the skin, that does not have an obnoxious odor, that is significantly less damaging to hair, that allows for the immediate shampooing of hair thereafter and that provides for re-treatment of the hair without additional damage, primarily using urea and high temperatures to break and reform disulfide bonds as a means to allow for the penetration of low molecular weight proteins into the shaft of the hair.

Alzheimer's disease is characterized by the presence of senile plaques formed from beta amyloid (Abeta), and neurofibrillary tangles (NTFs) formed from paired helical filaments consisting of hyperphosphorylated tau. A number of studies have shown that the NTFs correlate better with the duration and severity of Alzheimer's disease than senile plaques. However, a criticism of the primary etiological role of NTFs in Alzheimer's disease is the absence of variants of kinases or phosphatases associated with Alzheimer's disease. Acid phosphatase, a product of the ACP 1 gene, is a ubiquitous low molecular weight protein tyrosine phosphatase. A common allele, ACP 1*A, is associated with a lower activity of acid phosphatase. It is due to an Arg 105 Gln substitution of the ACP1 locus and detected as a Taq I polymorphism. We report a significant association of the low activity 2 allele with sporadic early onset Alzheimer's disease (EOAD). These findings support the possibility that other variants of kinase and genes may be associated with sporadic Alzheimer's disease.

Disclosed is a soy phytochemical composition obtained by removing soluble components out of acidified soy molasses by settling, decantation and / or centrifugation to obtain a precipitated residue sediment containing not less than 6% of isoflavones, not less than 18% of saponins and not less than 13% of crude low molecular weight protein material on a dry matter basis.

The present invention is directed to five novel, low molecular weight proteins from Actinobacillus pleuropneumoniae (APP), which are capable of inducing, or contributing to the induction of, a protective immune response in swine against APP. The present invention is further directed to polynucleotide molecules having nucleotide sequences that encode the proteins, as well as vaccines comprising the proteins or polynucleotide molecules, and methods of making and using the same.

Herein are provided, inter alia, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods of using the same. In embodiments, the compound has a structure according to Formula (I-A).

Low molecular weight protein tyrosine phosphatase (LMW-PTP) is identified as a novel diagnostic and therapeutic target in cancer diagnosis, prognosis and treatment. The invention provides diagnostic and treatment methods useful in connection with cancers expressing LMW-PTP and, optionally, EphA2 receptor. Also provided is a screening method that utilizes changes in the amount and / or activity of LMW-PTP to identify candidate cancer therapeutic agents that effectively target the oncoprotein EphA2.

The invention discloses low molecular weight protein which is produced from vitamin K2 fermentation waste liquid, so that resource waste is reduced, and meanwhile, the problem of environmental pollution caused by the fermentation liquid is well solved; and a good application prospect is guaranteed. Meanwhile, a method provided by the invention is low in raw material cost, simple in equipment, convenient to operate, easy for implementation of large-scale production and capable of improving added value of the industry.

The invention relates to the technical field of a functional material, and discloses a preparation method of a magnetic mesoporous silica core-shell structure affinity microsphere based on metal ion modification. The method comprises the following steps of: 1) preparing magnetic particles from hexahydrate ferric trichloride; 2) preparing particle dispersion liquid by utilizing the magnetic particles; 3) adding ethanol solution containing ethyl silicate and titanium tetrabutoxide to the particle dispersion liquid, carrying out ultrasound, agitation and magnetic separation, and removing template molecules to obtain the magnetic mesoporous silica core-shell structure taking the magnetic particles as a core and the SiO2 as a shell. Polypeptide and protein with low molecular weight can be gathered and purified from a complicated biological sample by utilizing the magnetic mesoporous silica core-shell structure affinity microsphere based on the metal ion modification. The purification and separation processes of complicated low-abundance protein and low-molecular weight protein sample are greatly simplified by utilizing the magnetic property of an affinity material; and the operation time is also shortened.