The present invention relates to methods and compositions designed for treatment, management, or prevention of a hyperproliferative
cell disease, particular
cancer. The methods of the invention comprise the administration of an effective amount of a composition that targets cells expressing
low molecular weight protein tyrosine kinase (“LMW-PTP”) in particular using moieties that bind an Eph family
receptor tyrosine kinase, such as EphA2 or EphA4, and inhibits or reduces LMW-PTP expression and / or activity. In one embodiment, the method of the invention comprises administering to a subject a composition comprising an EphA2 or EphA4 targeting
moiety attached to a
delivery vehicle, and one or more agents that inhibit LMW-PTP expression and / or activity operatively associated with the
delivery vehicle. In another embodiment, the method of the invention comprises administering to a subject a composition comprising a
nucleic acid comprising a
nucleotide sequence encoding an EphA2 or EphA4 targeting
moiety and an agent that inhibits or reduces LMW-PTP expression and / or activity. In yet another embodiment, the method of the invention comprises administering to a subject a composition comprising an EphA2 or EphA4 targeting
moiety and a
nucleic acid comprising a
nucleotide sequence encoding an agent that inhibits or reduces LMW-PTP expression and / or activity, where the
nucleic acid is operatively associated with the
delivery vehicle. Pharmaceutical compositions are also provided by the present invention.