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Blood purifying apparatus

A purifier and blood technology, applied in chemical instruments and methods, suction instruments, membranes, etc., can solve the problems of contamination of dialysate pipelines and dialyzers, and difficulty in fully preventing endotoxin effects.

Inactive Publication Date: 2004-12-15
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, in these known technologies, if the performance of the dialyzer is further improved, it may be difficult to sufficiently prevent the influence of endotoxin due to deterioration of the filter for removing endotoxin or contamination of the connecting part between the dialysate line and the dialyzer.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] 17% by weight of polysulfone (manufactured by AMOCO: P-1700) and 9% by weight of PVP (manufactured by ISP: K-90) were dissolved in 74% by weight of dimethylacetamide, stirred and dissolved for 10 hours to obtain a membrane-forming stock solution. The viscosity of this membrane-forming stock solution was 2400 mPa·s at 45°C. Secondly, use 30% dimethylacetamide aqueous solution as the hollow agent, discharge it from a ring nozzle with a slit width of 59.5 μm, and make it pass through the lower part of the nozzle hole after running at a spinning speed of 50 m / min. After being placed in a coagulation bath filled with water, it is rolled into a cylinder. Due to the adjustment of the discharge volume of the stock solution, the thickness of the hollow fiber membrane during drying reaches 45 μm, the discharge line speed of the stock solution reaches 45.5 m / min, and the draft ratio is 1.1. The hollow fiber bundle thus rolled into a tube was cut and washed by spraying hot water a...

Embodiment 2

[0118] 17% by weight of polysulfone (manufactured by AMOCO: P-1700) and 10% by weight of PVP (manufactured by ISP: K-90) were dissolved in 73% by weight of dimethylacetamide, stirred and dissolved for 10 hours to obtain a membrane-forming stock solution. The viscosity of this membrane-forming stock solution was 2650 mPa·s at 45°C. Secondly, use 35% dimethylacetamide aqueous solution as the hollow agent, discharge it from an annular nozzle with a slit width of 59.5 μm, and run the free-running part of 60 cm at a spinning speed of 50 m / min, and then make it pass through the lower part of the nozzle hole. After being placed in a coagulation bath filled with water, it is rolled into a cylinder. Due to the adjustment of the discharge volume of the stock solution, the thickness of the hollow fiber membrane during drying reaches 45 μm, the line speed of the stock solution discharge reaches 26.3 m / min, and the draft ratio is 1.9. After the hollow fiber bundle that is rolled into tubu...

Embodiment 3

[0121] 18% by weight of polysulfone (manufactured by AMOCO: P-1700) and 9% by weight of PVP (manufactured by ISP: K-90) were dissolved in 73% by weight of dimethylacetamide, stirred and dissolved for 10 hours to obtain a membrane-forming stock solution. The viscosity of this membrane-forming stock solution was 3320 mPa·s at 45°C. Secondly, use 32% dimethylacetamide aqueous solution as the hollow agent, discharge it from a ring nozzle with a slit width of 59.5 μm, and make it pass through the lower part of the nozzle hole after running at a spinning speed of 50 m / min. After being placed in a coagulation bath filled with water, it is rolled into a cylinder. Due to the adjustment of the discharge volume of the stock solution, the thickness of the hollow fiber membrane during drying reaches 45 μm, the line speed of the stock solution discharge reaches 38.5 m / min, and the draft ratio is 1.3. After the hollow fiber bundle that is rolled into tubular shape like this is processed in ...

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Abstract

A blood purifying apparatus having excellent purification performance (elimination of low molecular proteins, etc.) and being contaminated with little endotoxins flowing from the dialyzate side. Attention was paid to the solute permeability coefficient alpha and water permeability performance Lp of blood purifying apparatus and the relation between alpha and Lp has been examined. As a result, a blood purifying apparatus having excellent purification performance and substantially being free from invasion of endotoxins was obtained by regulating the value alpha / Lp to 6x10<-7> or above, or regulating alpha within a range of 8x10<-5> to 1.5x10<-3>, and the value alpha x Lp to 2.4x10<-2> or less. Also, a blood purifying apparatus having excellent purification performance and substantially being free from invasion of endotoxins was obtained by regulating the invasion ratio which is obtained by the polymer invasion test to 10% or less. The blood purifying apparatus has an excellent blood purifying performance expressed typically by the elimination ratio of low-molecular weight proteins and is substantially free from invasion of endotoxins from the dialyzate side, which makes it useful in, for example, treating patients with renal dysfunction.

Description

technical field [0001] The present invention relates to a blood purifier with high blood treatment ability for removing low-molecular protein and the like, and having less endotoxin flowing from the dialysate side. Background technique [0002] In the past, the purpose of blood purifiers used in hemodialysis therapy or filtration therapy was to remove metabolic breakdown products or harmful substances accumulated in blood from blood based on the principles of diffusion and filtration. For example, in 1943, Kolff et al. developed a drum type (drum Since type) hemodialyzers, membrane dialyzers have been used effectively in the treatment of patients with partial or complete loss of renal function. [0003] In general, the removal of metabolic decomposition products or harmful substances is mainly carried out by membranes. As membrane materials, membranes made of regenerated cellulose or membranes made of synthetic polymers such as polyacrylonitrile, polysulfone, and polyethylen...

Claims

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Application Information

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IPC IPC(8): A61M1/16B01D63/02B01D67/00B01D69/02B01D69/08B01D71/68
CPCB01D69/02B01D67/0086B01D2325/022B01D67/0011B01D71/68A61M1/16B01D69/08B01D63/02
Inventor 上住敏士吉田一
Owner ASAHI KASEI MEDICAL CO LTD
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