49 results about "Left anterior cruciate ligament" patented technology

A prosthetic knee implant for implantation into a mammal, which accommodates an anterior cruciate ligament substitute to provide stability to the knee implant. The prosthetic knee implant includes a femoral component having a pair of condylar surfaces and a tibial component having a surface portion adapted to slidably engage the femoral component upon rotation of the same. The femoral component further includes a recess between the condyles defining an aperture through the femoral component. The tibial component further includes a center portion defining an aperture through the tibial component substantially at its center. The femoral aperture and the tibial aperture are adapted to receive an anterior cruciate ligament substitute for biasing the mammalian femur and tibia together. Also disclosed is a method used to replace the total knee joint in a mammal with the improved prosthetic knee implant of the present invention.

A prosthetic knee implant for implantation into a mammal, which accommodates an anterior cruciate ligament substitute to provide stability to the knee implant. The prosthetic knee implant includes a femoral component having a pair of condylar surfaces and a tibial component having a surface portion adapted to slidably engage the femoral component upon rotation of the same. The femoral component further includes a central femoral recess between the condyles providing access to the femur for drilling a channel through which a cruciate ligament substitute may be integrated into the femur. The tibial component further includes a center portion defining an aperture through which the ligament substitute maybe threaded through the tibia and integrated therein, or anchored upon its surface. Also disclosed is a method used to replace the total knee joint in a mammal with the improved prosthetic knee implant of the present invention.

A prosthetic knee implant for implantation into a mammal, which accommodates an anterior cruciate ligament substitute to provide stability to the knee implant. The prosthetic knee implant includes a femoral component having a pair of condylar surfaces and a tibial component having a surface portion adapted to slidably engage the femoral component upon rotation of the same. The femoral component further includes a recess between the condyles defining an aperture through the femoral component. The tibial component further includes a center portion defining an aperture through the tibial component substantially at its center. The femoral aperture and the tibial aperture are adapted to receive an anterior cruciate ligament substitute for biasing the mammalian femur and tibia together. Also disclosed is a method used to replace the total knee joint in a mammal with the improved prosthetic knee implant of the present invention.

The simulation of physiological functions for monitoring and evaluation of bodily strength and flexibility includes a method and system for automated biomechanical analysis for simulated bodily joint movements. In one use, the simulation supports anterior cruciate ligament (ACL) injury prevention and recovery. The disclosure includes processing an automated and simulated biometric analysis algorithm on a computer processor and recording measurements relating to a plurality of physical therapy tests. The disclosure tracks the movement of joints on the subject's body from the subject's trunk downward to the subject's toes and calculates the results of the physical therapy tests for analyzing angles, movement quality, and related interrelationships amongst said joints. The method and system further derive and provide reports of comparisons of results with normative values and associate indicators for the comparisons to the potential of the subject to experience biomechanical conditions of injury or development.

The invention relates to an artificial anterior cruciate ligament stretching and twisting combined load fatigue simulation device and a testing method thereof, and belongs to the technical field of biomechanical property testing devices for biomedical textiles. The device comprises a computer, a fabric strength tester, a tensile torsional fatigue testing device, a mechanical sensor and an upper end clamp, according to the invention, the stress environment of a human autologous anterior cruciate ligament under complex conditions is simulated in vitro; a tensile and torsional combined load fatigue simulation test is carried out on artificial anterior cruciate ligament samples with different fixed elongation rates, torsional angles and coating conditions; the blank of the artificial anteriorcruciate ligament stretching and torsion combined load fatigue performance test is filled, and a qualitative and quantitative theoretical basis is provided for the development of artificial anterior cruciate ligament products and the selection of clinicians.

A system and method of diagnosing tissue integrity related to a joint of a patient may include imaging a first bone of the joint of the patient, determining a bone density profile of the first bone based on results of the imaging step, comparing the bone density profile of the first bone to at least one reference bone density profile of a reference first bone, and predicting an integrity of a tissue with respect to the first bone based on the comparison. The first bone may be a tibia and the bone density profile of the tibia may include a bone density profile of a sulcus of a medial tibial condyle of the tibia. The tissue may be an anterior cruciate ligament (“ACL”) and the predicting step may include predicting the integrity of both an anteromedial bundle and a posterolateral bundle of the ACL.

The invention provides an integral annular suspension artificial ligament, which comprises a ligament woven part (1) and a traction line (2), wherein the ligament woven part (1) has an enclosed annular structure; and the traction line (2) is connected to the ligament woven part (1). The invention further provides a corresponding preparation method. The integral annular suspension artificial ligament has the beneficial effects that: fixation of the artificial ligament can be enhanced, and the contact area between the artificial ligament and a bone tunnel can be increased during reconstruction of a human anterior cruciate ligament by using the artificial ligament, so that healing of the artificial ligament and the bone tunnel is facilitated; and moreover, the integral annular suspension artificial ligament is simple in structure, and is convenient to use.

The invention discloses application of DGCR8 in preparing products for treating and / or preventing osteoarthritis of animals. It shows that the DGCR8 has the following functions of treating and / or preventing the osteoarthritis of the animals, treating and / or preventing osteoarthritis induced by anterior cruciate ligament transaction of the animals, delaying senescence of mesenchymal stem cells, delaying replicative senescence of the mesenchymal stem cells, and delaying pathological senescence of the mesenchymal stem cells. Experiments show that the DGCR8 has the clear function of delaying senescence of the mesenchymal stem cells and has the clear treatment effect in osteoarthritis diseases, thus a new thought is provided for development of gene therapy for osteoarthritis, and the selectingrange of clinical gene therapy is expanded.

The invention relates to an artificial ligament in-vitro simulation fatigue simulation and online mechanical monitoring synchronous test device and test method, and belongs to the technical field of biomedical textile fatigue performance test devices. The test device comprises a computer, a fabric strength instrument, an online mechanical monitoring assembly, a tensile fatigue testing device assembly, a buckling fatigue testing device assembly and a torsional fatigue testing device assembly. According to the invention, the stress environment of stretching, buckling and twisting multiple loadsof a human autologous anterior cruciate ligament is simulated in vitro; the fatigue resistance of the artificial ligament in the conditions of different constant-force tensile loads, buckling angles and torsion angles is investigated, a relatively simulated test method is provided for the in-vitro fatigue simulation test of the artificial ligament, and meanwhile, the stress condition of the artificial ligament is monitored and acquired in real time to predict the service life of the artificial ligament such that a certain theoretical reference basis is provided for the research and developmentof the artificial ligament.

The present invention relates to a medicine composition for effectively curing injury of anterior cruciate ligament of knee joint. Said medicine composition contains trans forming growth factor, matrix metal proteinase inhibitor and inflammation bloker, and the optimum components of said medicine composition are transforming growth factor + vitamin A acid + tetracycline + NF -k B inhibitor.

A real time visualization method and system for evaluating and monitoring recovery progress of Anterior Cruciate Ligament reconstructed / injured subject is provided. The method includes receiving multiple super-imposed bio-signals from an electromyogram (EMG) for muscles of limbs of the patient and signals pertaining to three dimensional kinematics measurement from a motion sensor set, processing the signals to extract wavelet features and evaluating the wavelet features to determine the extent of rehabilitation and a recovery classification of the patient's limb from ACL injury. The system includes an input interface circuit, a processing module, a comparator module and an output interface circuit for providing an estimate of the extent of rehabilitation the patient's limb from ACL injury.

A knee brace includes a sleeve; and a plurality of flaps including a first lateral flap coupled to a first side of the sleeve and configured to extend toward a center of the sleeve; a second lateral flap coupled to a second side of the sleeve substantially opposite to the first side and configured to extend toward a center of the sleeve and overlap with the first transverse flap; a first transverse flap and a second transverse flap coupled to a rear side of the sleeve and configured to wrap around the first side and the second side of the sleeve, respectively, and overlap the first and second lateral flaps. Additionally, the knee brace may include a lower flap as an anterior cruciate ligament support and first and second transverse straps configured to extend over the plurality of flaps.

The [Ligament End Feel Simulator] has the sole purpose of teaching athletic training students and other medical professionals what laxity of the anterior cruciate ligament feels like without the need for a live injured patient to be present. The novelty of the present invention comes from the non-existence of the present invention in the athletic training profession. Although a person not knowledgeable in the art can look at the present invention and recognize it as being a knee; the average person and even most medical professionals will not know that the device is meant to be used in conjunction with the Lachman manual special test.

Apparatus for locating an attachment position for a reconstructed anterior cruciate ligament on an attachment surface of a bone comprises locating means 51, 61 arranged to locate at least one reference surface 4 of the bone and guide means 53, 54 arranged to define the attachment position in two dimensions on the attachment surface relative to the reference surface.

Various exemplary methods, systems, and devices for blood flow are provided. In general, an implant can be configured to be implanted in bone and to delay clotting of blood flowing from the bone. The implant can include an anti-coagulation agent to delay the clotting of the blood. The anti-coagulation agent can be a coating on the implant, can be natural to a material forming the implant, or can be impregnated into a material forming the implant. In an exemplary embodiment, the implant is implanted in a bone in a surgical procedure for securing a soft tissue to bone, such as a rotator cuff repair procedure or an anterior cruciate ligament (ACL) repair procedure.

The invention provides a multivariate time sequence classification method based on deep learning, and the method employs a BaseCNN to capture the interaction between variables, also employs an LSTM with a long-distance dependence capability to construct a sub-network, employs the long-term memory characteristic of the sub-network, strengthens the global time sequence characteristics of a model, and helps the model to better capture the global time sequence characteristics. Besides, a three-step training mode is ingeniously designed, the functions of Center Loss and Triplet Loss are effectively played, the characteristics of volatility and specificity of the data set are processed, and good characteristic embedding is provided for a final classification network. The artificial intelligent anterior cruciate ligament auxiliary diagnosis method greatly promotes the research of the existing artificial intelligent anterior cruciate ligament auxiliary diagnosis, and has great clinical significance and practical application value.

The invention discloses a method and device for directly measuring articular surface pressure in real time, the device is composed of a flexible pressure sensor, a signal acquisition device and a signal output device, the flexible pressure sensor converts a pressure signal in a joint into an electric signal, and then the signal acquisition device and the signal output device are used for respectively acquiring and outputting electric signal data. By utilizing the characteristic that the sensor arranged in the joint can convert a pressure signal into an electric signal which can be output under a pressure condition, accurate measurement and real-time monitoring of the pressure change of the joint surface are realized. The device is suitable for various disease models, such as joint disc displacement, joint disc perforation, anterior cruciate ligament fracture, degenerative joint diseases and the like.

The invention discloses application of oxymatrine to preparation of a medicine for resisting osteoclast-mediated bone loss. According to the application, the oxymatrine is innovatively used for treating osteoclast-mediated osteolytic diseases and an inhibition effect of the oxymatrine on osteoclast differentiation is explained for the first time at a cellular level. Meanwhile, a bone and joint unstable model is manufactured by applying anterior cruciate ligament transection; the model has mouse knee joint subchondral bone loss and cells with an osteolysis effect are osteoclasts; an animal experiment result shows that the osteoclast differentiation-mediated subchondral bone loss can be remarkably reduced through intraperitoneal injection of the oxymatrine and the medicine has a remarkable protection effect on mouse joints. Finally, under in vivo conditions, the invention proves that the oxymatrine has no remarkable toxin on visceral organs in a whole body and an ideal new option is provided for treatment of the osteolytic diseases.

The invention provides a silk ligament and a preparation method thereof, and relates to the field of prosthetic materials. The silk ligament is prepared from natural silk serving as raw materials by stranding, twisting, degumming and bone morphogenetic protein (BMP) filling, and consists of lead wires (1), an inner core (2) and a core shell (3), wherein the lead wires (1), the inner core (2) and the core shell (3) are formed by weaving integrally; the core shell (3) is fixed on the middle part of the inner core (2); and the lead wires (1) are fixed at both ends of the inner core (2). Compared with the conventional artificial ligament, the mechanical property of the silk ligament are in stricter accordance with the properties of anterior cruciate ligaments (ACL) of human bodies, and after being filled with the BMP, the silk ligament rebuilding is more convenient.

The invention discloses an anterior cruciate ligament stump expander. The anterior cruciate ligament stump expander comprises a guide needle, an expansion head, a push rod and a handle, wherein one end of the guide needle is a guide needle head, and the other end of the guide needle is connected with the handle; the expansion head is of a hollow structure internally provided with an elastic framework; the expansion head sleeves the guide needle; one end, close to the guide needle head, of the expansion head is a fixed end fixedly connected with the guide needle, and the other end, far away from the guide needle head, of the expansion head is a sliding end in sliding connection with the guide needle; the push rod is of a hollow pipe body structure; the push rod is arranged between the expansion head and the handle and sleeves the guide needle; and one end of the push rod is connected with the sliding end of the expansion head, and a locking part is arranged at the other end of the push rod. The anterior cruciate ligament stump expander is applied to the cruciate ligament residue protection reconstruction operation, the purpose that the residual ACL ligament wraps the graft to the maximum degree can be simply and efficiently realized, the intercondylar fossa collision is avoided, thus the postoperative complications are reduced, and the prognosis of the patient is improved.

The invention discloses an anterior cruciate ligament stump end dilator, which relates to the technical field of medical instruments. The anterior cruciate ligament stump end dilator comprises a guide needle, a dilation head and a handle, wherein one end of the guide needle is a guide needle head, and the other end of the guide needle is connected with the handle; the dilation head is installed on the guide needle, the dilation head is fixedly connected with the guide needle, and the dilation head is arranged close to the guide needle head. According to the method, the residual ACL ligament can wrap the graft to the maximum extent simply and efficiently.

The invention provides an adjustable anti-shearing rehabilitation protector, which comprises a flexible sleeve used for simultaneously covering thighs and shanks on the same side of a human body and bending and stretching along with the thighs and the shanks; the brace assembly is fixedly connected to the outer side of the flexible sleeve and used for being matched with the flexible sleeve to move along with the legs of the human body; the shank protective cover is connected to the part, corresponding to the shank, of the flexible sleeve through a screw, a gasket is further arranged in front of the position, corresponding to the upper section of the tibia, between the flexible sleeve and the shank protective cover, so that the insertion end of the screw abuts against the gasket through the shank protective cover and is used for controlling the displacement of the tibia towards the front side. The structure has the advantages that the screw is screwed in and extrudes the gasket for limitation, so that the gasket does not fall off in the use process, and meanwhile, the structure has the effect similar to an anterior cruciate ligament.

The invention belongs to the field of biomaterials, and discloses a composite fiber for artificial anterior cruciate ligament, a preparation method and application thereof. In the present invention, polyhydroxyhexyl butyrate and polyglycolic acid are composited, and the obtained composite fiber combines the advantages of both, and has both the good biocompatibility of polyhydroxybutyrate and polyglycolic acid Endowed with excellent physical and mechanical properties and cell affinity and other properties. In addition, based on the synergistic reinforcement mechanism, the composite fiber has superior performance than the single component. When the composite fiber is used to prepare the artificial anterior cruciate ligament, the new composite ligament exhibits the characteristics of strong wear resistance, good tissue compatibility and cell affinity, and high mechanical properties, which can meet the basic requirements of the artificial anterior cruciate ligament .

The invention relates to an artificial anterior cruciate ligament tensile and torsion composite load fatigue simulation device and a testing method thereof, and belongs to the technical field of testing devices for biomechanical properties of biomedical textiles. Including computer, fabric strength tester, tensile torsion fatigue testing device, mechanical sensor and upper end fixture; the present invention simulates the stress environment of human anterior cruciate ligament under complex conditions in vitro, and has different elongation, torsion angle and coating The artificial anterior cruciate ligament specimen in the multi-layer condition is subjected to the tensile torsion composite load fatigue simulation test, which makes up for the blank of the artificial anterior cruciate ligament tensile torsion composite load fatigue performance test, and provides a basis for the development of artificial anterior cruciate ligament products and the selection of clinicians. Qualitative and quantitative theoretical basis.

The invention discloses the application of YAP in preparing products for treating and / or preventing animal osteoarthritis. The present invention finds that YAP has the following functions: treating and / or preventing animal osteoarthritis; treating and / or preventing animal anterior cruciate ligament cut-induced osteoarthritis; delaying the aging of mesenchymal stem cells; delaying the replication of mesenchymal stem cells Sexual aging; Delaying pathological aging of mesenchymal stem cells. The experiment of the present invention proves that YAP has a definite function of delaying the aging of mesenchymal stem cells, and YAP has a definite therapeutic effect in osteoarthritis diseases. The invention provides a new idea for the development of gene therapy for osteoarthritis, and expands the optional range of clinical gene therapy.

The present application relates to sutureless methods for repairing soft tissue defects in soft tissue including ligaments such as the anterior cruciate ligament (ACL). In particular, the present application relates to a sutureless method of repairing a soft tissue defect, said method comprising: (i) providing a collagen-containing patch adapted to surround at least part of said soft tissue defect; (ii) making said soft tissue defect and / or contacting the collagen-containing patch with a sensitizer; (iii) enclosing the soft tissue defect in the collagen-containing patch to form a bioactive cavity; and (iv) adhering the collagen-containing patch to The soft tissue defect was not sutured.

The invention belongs to the technical field of biomechanical characteristic measuring devices, and discloses an anterior cruciate ligament biomechanical characteristic measuring device. The device comprises a fixing assembly, a rotating assembly, a tension measuring assembly, a torsion measuring assembly, a moving assembly and a bottom plate, wherein the fixing assembly is used for fixing one end of an anterior cruciate ligament, the rotating assembly is used for realizing the rotation of the fixing assembly, the tension measuring assembly comprises a first driving part and a tension measuring part, and the first driving part is used for driving the movement of the tension measuring part. The device has the advantages of simple structure and convenient use, can perform tension measurement and torsion measurement, and the two measurements are carried out separately without mutual interference; secondly, by arranging the rotating assembly, the output end of a second motor is used for driving a supporting block at the top end of a stand column to rotate, so that the rotation of the fixing assembly can be realized, the direction of the fixing assembly can be quickly adjusted when different measurements are carried out, and the quick fixation of the ligament to be measured is facilitated.

The invention discloses a paging type ligament regeneration enhancing support and a preparation method thereof. The paging type ligament regeneration enhancing support comprises a plurality of pages,and the side face where the long edge of each page is located is fixedly connected to form a middle shaft; each page is sequentially divided into a first bone tunnel part, a joint cavity part and a second bone tunnel part in the long side direction. The paging type ligament regeneration enhancing support can enhance cell migration adhesion and blood vessel regeneration, promote ligament tissue regeneration and enhance tendon-bone interface regeneration in a bone canal, so that the clinical curative effect of a ligament graft for reconstructing an anterior cruciate ligament is improved, and theclinical requirement is very large.

The invention discloses an anterior cruciate ligament stump strengthening dilator which comprises a guide needle, a dilation head, a push rod and a handle. One end of the guide needle is a guide needle head, a push rod sleeves the guide needle, one end, close to the guide needle head, of the push rod is connected with an expansion head which also sleeves the guide needle, and the other end of the push rod is connected with a handle which is in sliding connection with the guide needle. The anterior cruciate ligament stump strengthening dilator is simple in structure and convenient to operate, is applied to a cruciate ligament stump protection reconstruction operation, and can simply and efficiently realize that the residual ACL ligament wraps a graft to the maximum extent and avoid intercondylar fossa collision, so that postoperative complications are reduced, and the prognosis of a patient is improved.