The invention belongs to the field of traditional Chinese medicines (TCMs) and discloses a TCM composition and application thereof. The composition comprises the following TCMs in parts by weight: 0.11-97.0 parts of musk, 10.0-50.0 parts of gypsum, 0.05-10.0 parts of borneol, 5.0-15.0 parts of pseudo-ginseng, 4.5-9.0 parts of cuttlebone, 3.0-9.0 parts of silkworm cocoons, 3.0-6.0 parts of human urine sediment, 4.0-80.0 parts of calcined gypsum, 0.5-25.0 parts of pearls, 2.0-12.0 parts of frankincense, 2.0-12.0 parts of myrrh, 1.0-10.0 parts of sanguis draconis, 1.0-10.0 parts of rhizoma coptidis, 3.0-20.0 parts of horseshoe crab shells, 0.2-2.0 parts of dragon bones, 9.0-30.0 parts of oysters and 0.5-15.0 parts of carbonized human hair. The TCM composition has the functions of clearing away heat and toxic materials, activating blood circulation to dissipate blood stasis, carrying out sterilization to diminish inflammation, relieving pains, diminishing swelling and promoting granulation, inducing astringency and stopping slippage and astringing dampness and carrying out astringency. The TCM composition can be used for preparing the medicines for treating bedsore, ecthyma, scrofula sore, hemorrhoids, burns, scalds, tympanitis or diabetic foot.