42 results about "Flavanolol" patented technology

The invention discloses photinia serrulata procyanidine as well as a preparation method and an application thereof. The photinia serrulata procyanidine is prepared by extracting and purifying rachis of a photinia plant as an effective component. According to the photinia serrulata procyanidine as well as the preparation method and application, the branches, leaves and fruits of the photinia plant contain extremely high procyanidine like substances, and the matured rachis contain the most procyanidine; the plant extractive prepared through the rachis of the photinia plant by purifying has the antioxidant activity under low concentration higher than that as specified in the specification under the same mass concentration; and the chemical component analysis sheet shows that the contents of flavonoid components, phenol components and symbolic flavane-3-alcohol antioxidant components in the extractive are higher than that as specified in the specification. The raw materials of the extractive are easily obtained, the extracting process is simple, the cost is small, and wide market prospect and high economic value are brought.

Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the structure of formula (I)wherein R1 through R3 and R5 through R11 are defined herein, and α, β, and γ are optional bonds, providing that when α is absent, β is present, and when β is absent, α is present. When α is present, preferred R4 moieties are selected from O, S, NH and CH2, and when α is absent, preferred R4 groups are selected from OH, SH, NH2 and CH3. When γ is present, the preferred R5 substituent is O, while when γ is absent, the preferred R5 substituent is OH. Pharmaceutical compositions are provided as well, as are methods of synthesis and use.

The invention discloses a method for analyzing a proanthocyanidin structure through combination of hydrophilic interaction and reversed-phase liquid chromatography. The method comprises the following steps: analyzing a flavan-3-alcohol monomer; carrying out acid degradation on the proanthocyanidin to obtain an acid degradation product to be analyzed; analyzing the acid degradation product to be analyzed by using reversed-phase liquid chromatography (RPLC), analyzing the type and content of terminal units of proanthocyanidin according to the difference of the type and content of flavane-3-alcohol analyzed by the RPLC and Hilic, and analyzing the type and content of extension units of proanthocyanidin according to the flavane-3-alcohol-phloroglucinol addition product analyzed by the RPLC and the anthocyanidin; and calculating the average polymerization degree of the proanthocyanidin according to the mole number of the proanthocyanidin extension unit and the mole number of the terminal unit. According to the scheme, the step of directly removing flavane-3-alcohol in a sample in a traditional method (time consumption is long) is replaced, and the analysis speed of the terminal unit of the proanthocyanidin is greatly increased.

The invention provides 19 novel flavanol-fatty alcohol hybrids, as shown in a structural formula (I), tsaokoflavanols A-S 1-19, as well as a preparation method, pharmaceutical composition and application thereof, and relates to the technical field of medicines. The compound disclosed by the invention has obvious inhibitory activity on PTP1B and alpha-glucosidase, can form the pharmaceutical composition together with a medicinal carrier or an excipient, and can be used for preparing PTP1B and alpha-glucosidase inhibitor drugs, hypoglycemic drugs or health-care foods.

The invention relates to a flavane-3-alcohol acylpropanoid heterocomplex and a preparation method and application thereof, and belongs to the technical field of natural pharmaceutical chemistry and medicine. The inventor of the invention separates a new flavane-3-alcohol acylpropanoid heterocomplex from the whole herb of mentha piperita, and accidentally finds that the compound has an obvious anti-inflammatory effect in a further pharmacodynamic research process. The flavane-3-alcohol acylpropanoid heterocomplex disclosed by the invention has a clinical application prospect of an anti-inflammatory drug.

The invention relates to methods for the preparation of an optically inactive and optically active compounds which are selected from the group consisting of C-3 coupled biflavonoids and C-3 coupled biflavonoid analogues from a starting material or intermediate which are respectively selected from the group consisting of optically inactive or optically active flavan-3-ols and optically active flavan-3-ones, the method comprising the steps of (a) providing an optically inactive or active compound having a fIavan-3-ol structure or a compound which is a flavan-3-one, (b) if a compound having a flavan-3-ol structure with a hydroxy group on the C-3 carbon is selected as starting material, converting the hydroxy group on the C-3 carbon of the compound having the flavan-3-ol structure to an oxo group to form a flavan-3-one of that compound, (c); providing a compound having a nucleophilic aromatic moiety, which compound is selected from the group of compounds having a nucleophilic aromatic moiety and which have flavonoid base structures and compounds having a nucleophilic aromatic moiety and which do not have a flavonoid base structure, (d) contacting the flavan-3-one provided by step (a) or obtained by step (b) with the compound containing the nucleophilic aromatic moiety in the presence of a Lewis acid; (e) forming a first intermediate compound wherein the oxo group on the C-3 carbon is converted to a hydroxy group by virtue of nucleophilic addition when the compound containing the nucleophilic aromatic moiety is contacted to the C-3 carbon of the flavan-3-one, (f) subjecting the first intermediate compound to dehydration so as to introduce a double bond between the C-3 carbon and C-4 carbon of the intermediate compound with the concomitant removal of the hydroxy group from the C-3 carbon to form an optically active flavene compound which is substituted by the nucleophilic aromatic moiety on the C-3 carbon, (g).

The invention discloses a preparation method of a gelatin-based food packaging film, which comprises the following steps: 1) mixing and soaking 16-30 parts by mass of gelatin and 100 parts by mass ofdistilled water for 0.5-1.5 hours to obtain a gelatin matrix; 2) adding 15-25 parts of a titanium compound aqueous solution with the concentration of 3-10g / L into the gelatin matrix; and adding 15-25parts of 0.5-2g / L high-polymerization-degree flavanol aqueous solution, adding 3-6 parts of 0.1-1.2 mol / L sodium hydroxide aqueous solution and 3-6 parts of glycerol, casting to form a film, and drying to obtain the finished product. According to the preparation method, natural polyflavanol and high-safety titanium ions are used as composite cross-linking agents, and the high-safety gelatin-basedfood packaging film with excellent physical and mechanical properties is prepared by utilizing a principle that protein reaction active sites are increased after the titanium ions and the polyflavanolform a coordination compound.