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Cortex choerospondias proanthocyanidins and preparation method and application thereof

A technology of proanthocyanidins and jujube jujube, which is applied in the fields of application, food preparation, and pharmaceutical formulations, can solve the problems that other biological activities of jujube bark have not been reported in literature, and achieve easy-to-obtain raw materials, good activity, and simple preparation methods Effect

Inactive Publication Date: 2014-12-17
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report about the content of the above-mentioned compounds in the bark of Zizyphus jujube and other biological activities of the bark of Zizyphus jujube

Method used

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  • Cortex choerospondias proanthocyanidins and preparation method and application thereof
  • Cortex choerospondias proanthocyanidins and preparation method and application thereof
  • Cortex choerospondias proanthocyanidins and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 A kind of preparation method of proanthocyanidins of southern jujube

[0032] Weigh 25g of dried southern jujube bark powder, place it in a 1000mL conical flask, add 800mL of 50% ethanol acidified with 0.5% (V / V) acetic acid, let it stand overnight, and place it in an ultrasonic generator at 40KHz the next day Ultrasonic extraction for 30min, Buchner funnel filtration, add 600mL 50% ethanol acidified with 0.5% acetic acid to the filter residue, ultrasonic extraction at 40KHz for 30min, Buchner funnel filtration, add 600mL 50% ethanol acidified with 0.5% acetic acid to the filter residue, 40KHz Ultrasonic extraction for 30 min, Buchner funnel filtration, three filtrates were combined, and the filtrate was concentrated under reduced pressure in a rotary evaporator at 45°C to obtain a concentrated extract, which was used for macroporous resin purification.

[0033] Take 200g of new D101 macroporous resin, put it into a chromatography column, soak it with 95% e...

Embodiment 2

[0046] Example 2 The preparation method of southern jujube proanthocyanidins

[0047] Weigh 50g of dried southern jujube bark powder, put it in a 2000mL beaker, add 1500mL of 70% ethanol acidified with 1.0% HCl (V / V) acetic acid, let it stand overnight, and place it in an ultrasonic generator at 40KHz the next day Ultrasonic extraction for 30min, Buchner funnel filtration, add 1200mL 70% ethanol acidified with 1.0% HCl to the filter residue, ultrasonic extraction for 30min at 40KHz, filter with Buchner funnel, add 1000mL 70% ethanol acidified with 1.0% HCl to the filter residue, 40KHz Ultrasonic extraction for 30 min, Buchner funnel filtration, three filtrates were combined, and the filtrate was concentrated under reduced pressure in a rotary evaporator at 45°C to obtain a concentrated extract, which was used for macroporous resin purification.

[0048] Take 400g of new X-5 macroporous resin, put it into a chromatography column, soak it with 95% ethanol for 24h, wash it with d...

Embodiment 3

[0049] Example 3 The preparation method of southern jujube proanthocyanidins

[0050] Take by weighing 50g dried Mao Mai Nan Suanzao bark coarse powder, place in a 2000mL beaker, add 1500mL of 70% methanol acidified with 1.0% HCl (V / V) acetic acid, let stand overnight, and place in an ultrasonic generator the next day, Ultrasonic extraction at 50KHz for 30min, Buchner funnel filtration, add 1200mL 70% methanol acidified with 1.0% HCl to the filter residue, ultrasonic extraction at 50KHz for 40min, Buchner funnel filtration, add 1000mL 70% methanol acidified with 1.0% HCl to the filter residue , ultrasonically extracted at 50KHz for 60min, filtered through a Buchner funnel, combined three filtrates, and concentrated the filtrate under reduced pressure in a rotary evaporator at 45°C to obtain a concentrated extract, which was used for macroporous resin purification.

[0051] Take 400g of new AB-8 macroporous resin, put it into a chromatographic column, soak it with 95% ethanol f...

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Abstract

The invention discloses a cortex choerospondias proanthocyanidins and a preparation method and application thereof. The cortex choerospondias proanthocyanidins is extracted and purified from an effective part of cortex choerospondias. The invention discloses that cortex choerospondias contains high content of procyanidins. The plant extract prepared from cortex choerospondias by purification has antioxidant activity at a low concentration higher than that of Pycnogenol in the same concentration. Chemical composition analysis shows that the extract the contents of antioxidant components such as flavonoids, phenolic compounds and iconic flavanone-3-alcohol are higher than thos in Pycnogenol. The extract has the advantages of easily available raw materials, simple extraction process and low cost, and has a very broad market prospects and economic values.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, and relates to proanthocyanidins from Jujube jujube and its preparation method and application. Background technique [0002] Proanthocyanidins, that is, polymers of flavan-3-ols such as catechin or epicatechin, usually have a degree of polymerization between 2 and 10, and di-pentamers are usually called low Poly proanthocyanidins (OPC) and pentamers are called high poly proanthocyanidins (PPC). Proanthocyanidins have a wide range of biological activities. In the medical and nutritional circles, proanthocyanidins are generally considered to be the strongest natural antioxidant substances that scavenge free radicals, and their free radical scavenging activity is about 50 times that of vitamin E of the same quality. The currently known plant extracts rich in proanthocyanidins mainly include pine bark extract - Pycnogenol , grape seed extract, black fruit wolfberry extract, European ling...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61K8/97A61P39/06A61Q19/08A23L1/30A23L2/52A23K1/16A61K129/00
Inventor 李鑫梁宗锁刘景玲毛仁俊杨星科
Owner NORTHWEST A & F UNIV
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