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56 results about "Dose interval" patented technology

Dose interval definition, dose interval meaning | English dictionary. dose. n a quantity that expresses the probability that exposure to ionizing radiation will cause biological effects. It is usually obtained by multiplying the dose by the quality factor of the radiation, but other factors may be considered.

Controlled/modified release oral methylphenidate formulations

The invention is directed to oral modified / controlled release methylphenidate formulations which provide a rapid initial onset of effect and a prolonged duration of effect. Preferably, the peak concentration is lower than that provided by the reference standard for immediate release methylphenidate formulations, and the duration of effect falls rapidly at the end of the dosing interval so as not to affect the appetite of the patient at dinner nor the patient's sleep thereafter.
Owner:RHODES PHARMA LP

Stimulus regimens for cardiovascular reflex control

InactiveUS20070049989A1Modulate activityModulation of the reflex control of the patient's circulationStentsSpinal electrodesElectricityControl signal
Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals (perhaps having durations commensurate with an interval between heartbeats), and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of the therapy intervals and also differs between first and second portions of at least some burst intervals.
Owner:CVRX

Patient Controlled Timed Medication Dispenser

A medication dispenser for permitting administration of a medication dose to an authorized user only after a predetermined minimum-dosing interval has elapsed. The medication dispenser comprises: a medication tray having a substantially circular shape and comprising a plurality of compartments containing a medication dose, the compartments disposed about a circumference thereof; regions between two consecutive dose-carrying compartments comprising an empty compartment or a blank region; an enclosure for supporting the dispenser, the enclosure including an opening; and a controller for controlling the medication tray to align one of the plurality of compartments containing a medication dose with the opening after the minimum dosing interval has elapsed and after a person has been authenticated as an authorized user, thereby permitting the authorized user to access the medication dose through the opening, wherein the medication dispenser remains in a dose-accessible configuration for a predetermined hold period, after which the medication tray is controlled to align a next successive empty compartment or blank region with the opening.
Owner:CONLEY N SHARON

Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia

The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
Owner:MALLINCKRODT INC

Methods of providing sustained treatment with opioids

A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg / ml to about 1052 pg / ml is attained, and thereafter maintaining the administration of buprenorphine for at least an addition two-day dosing interval in accordance with substantially zero order kinetics, such that the patients experience analgesia throughout the at least two-day additional dosing interval.
Owner:PURDUE PHARMA LP

Compositions Comprising An Opioid And An Additional Active Pharmaceutical Ingredient For Rapid Onset And Extended Duration Of Analgesia That May Be Administered Without Regard To Food

InactiveUS20140275143A1Reduce riskBiocideNervous disorderAdditive ingredientFasting state
The present disclosure provides pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state. The present disclosure further provides pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides reduced abuse potential.
Owner:MALLINCKRODT INC

Methods for administration of antibiotics

InactiveUS6852689B2Minimizes skeletal muscle toxicitySufficient efficacy levelAntibacterial agentsBiocideAntibiotic YSkeletal muscle
The invention provides methods for administering a therapeutically effective amount of daptomycin while minimizing skeletal muscle toxicity. The methods provide daptomycin administration at a dosing interval of 24 hours or greater. This long dosing interval minimizes skeletal muscle toxicity and allows for higher peak concentrations of daptomycin, which is related to daptomycin's efficacy. The invention also provides methods of administering lipopeptide antibiotics other than daptomycin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of the lipopeptide antibiotic at a dosage interval that does not result in muscle toxicity. The invention also provides methods of administering quinupristin / dalfopristin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of quinupristin / dalfopristin at a dosage interval that dos not result in muscle toxicity.
Owner:CUBIST PHARMA INC

Tray insert for medication on demand device

In one embodiment, the invention comprises a tray insert for a medication dispenser, the dispenser permitting access to a medication dose after a minimum dosing interval has elapsed since presentation of an immediately previous dose. The dispenser comprises a dispenser cover having an opening through which a patient accesses the medication dose presented through the opening and a carousel for receiving the tray insert. The tray insert comprises a substrate, a plurality of medication retention areas in the substrate each for holding at least one medication dose, each medication retention area received within a depression of the carousel and a cover removably affixed to an upper surface of the substrate for retaining the medication doses in the medication retention areas prior to use, wherein after the tray insert is mated with the carousel the cover.
Owner:AVANCEN MOD

Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia

The present disclosure provides an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
Owner:MALLINCKRODT INC

Pharmaceutical formulation for oral delivery of bisphosphates

InactiveUS20050182028A1Minimizing potential esophageal irritationMinimize irritationBiocidePhosphorous compound active ingredientsDosing regimenPharmacy
The present invention discloses a method for treating or preventing a bone disorder in a mammal in need thereof comprising orally administering to said mammal a pharmaceutically effective amount of a pharmaceutical composition of at least one bisphosphonate, or a pharmaceutically acceptable salt or esters thereof, and at least one aminoalky methacrylate copolymer, according to a dosing schedule having a dosing interval selected from once-weekly dosing, twice-monthly dosing, once-monthly, once-quarterly and once-annually dosing. The present invention further discloses a method for treating or preventing a bone disorder in a mammal in need thereof comprising continuously orally administering a unit dosage per-day to said mammal in a short time for a long time therapy.
Owner:CHEN CHIH MING JAMES

Preparation of SRB (sulfate reducing bacterium) biological inhibitor and method for inhibiting SRB in crude oil

The invention relates to a preparation method of an SRB (sulfate reducing bacterium) biological inhibitor, which comprises the following steps: by taking polyvinyl alcohol, sodium alginate, denitrifying bacterium suspension, calcium carbonate, boric acid, calcium chloride, silicon dioxide and water as raw materials, preparing an embedding agent, then preparing a microbial mixed solution, and finally preparing to obtain immobilized denitrifying bacterium balls. The prepared SRB biological inhibitor can be used in the inhibition of SRB in crude oil. Sodium nitrate particles are firstly added into an oil well casing port; then, the SRB biological inhibitor is added; and finally, water is added to flush the two chemicals to the bottom of a well, and the dosing interval of each time is 15 days, thus achieving the purpose of inhibiting the growth of SRB for a long time. According to the invention, by using the sodium nitrate particles to provide a nitrogen source for the denitrifying bacteria, an oil layer origin and exogenous denitrifying bacterium microorganisms are activated, and the original and exogenous microorganisms are utilized to change the growth environment of the system so as to quickly inhibit the growth of SRB in the oil well, thereby inhibiting the generation of hydrogen sulfide gas from the source and reducing corrosion and sulfide hazard caused by SRB.
Owner:SHAANXI URSTAR ENVIRONMENTAL SCI & TECH

Method for inhibiting bone resorption with an alendronate and vitamin d formulation

Composition and method for preventing or treating abnormal bone resorption in mammals, the composition characterized as containing, a supplementary effective amount of a non-activated metabolite of vitamin D2 and / or D3 and a pharmaceutically effective amount of bisphosphonate to provide vitamin D nutrition during treatment to facilitate normal bone formation and mineralization, while minimizing the occurrence of or potential for the complications associated with vitamin D insufficiency, such as hypocalcemia and osteomalacia. The method of preventing or treating may be further characterized by concomitantly administering the components simultaneously or alternately at dosing intervals selected from once-weekly, twice-weekly, bi-weekly, monthly, and bimonthly.
Owner:DAIFOTIS ANASTASIA G +2

Ambulatory Medication on Demand Dipsenser

A medication dispenser. The dispenser comprises a sensor for receiving biometric information from a user, a memory for storing a minimum dosing interval, a controller for determining whether the user is an authorized user, a belt having medication-carrying slots, a dose opening defined in an exterior surface of the dispenser, and a signaling device. The controller activates the signaling device and the sensor only when the minimum dosing interval has elapsed as measured from a last successful user authentication. The sensor is responsive to user biometric information provided any time after activation of the signaling device and the sensor, but not before activation of the signaling device and the sensor. After determining the use is an authorized user, a medication-carrying slot is aligned with the dose opening.
Owner:ADVANCEN MOD

Extended Release Compositions Comprising Hydrocodone And Acetaminophen For Rapid Onset And Prolonged Analgesia That May Be Administered Without Regard To Food

The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
Owner:MALLINCKRODT INC

Giant knotweed rhizome active ingredient emodin extraction method

The invention provides a method for extracting the effective component archin of the giant knotweed rhizome, which puts the drugs into five extracting tanks after shattering them to in turn extract the E, D, C, B, A tank with the extracting solution: 30%-70% alcohol whose amount is 8-12 volume of the drug's quality, the temperature: 35-65 deg. and the time: 20-50 minutes, so that the effect component of the extracting solution of the five tanks descendent, it then discharges opeing the tank which has the highest effect component and discharges the dross of the tank which has been five solution extracted, it dose interval removal to the other extracting solution and dose four cycles and then amalgamates the extracting solutions.
Owner:ZHEJIANG UNIV

Novel ceftriaxone sodium for injection

The invention relates to novel ceftriaxone sodium for injection and a preparation method thereof, and belongs to the technical field of medicines. The novel ceftriaxone sodium for injection consists of 1 part of ceftriaxone sodium, 0.30 to 0.33 part of ethyecellulose, 0.60 to 0.72 part of a stabilizer, 0.80 to 0.90 part of a surfactant, 70 to 80 parts of liquid paraffin and 0.27 to 0.30 part of ananti-sticking agent. The stabilizer p-dioxanone-lactide copolymer is a copolymer with a specific proportion, and plays an important role in preparation stability. According to the injection, the drugdelivery application twice every day becomes once administration through slow-release effect of a micro-capsule, the dosing interval is shortened, the injection is convenient to use, the biological availability is improved, the using amount of medicine is reduced, the curative effect is improved since the blood concentration is smooth, and the untoward effect is reduced. The novel ceftriaxone sodium for injection, provided by the invention, is simple in preparation technology and low in cost, is applicable for large-scale production, and is a product with very good market prospects.
Owner:石药集团中诺药业(石家庄)有限公司

Apremilast gel for injection to articular cavity and preparation method of apremilast gel

The invention mainly provides apremilast gel for injection to the articular cavity and a preparation method of the apremilast gel. According to the apremilast gel and the preparation method, polymer with the temperature-sensitive reverse gel property is adopted as a carrier material, and medicines are dispersed or dissolved in an aqueous solution of the carrier material. When the temperature is lower than the body temperature, a sample exists in the form of sol, and is injected into the body through a common syringe; when the temperature of the injected part rises to the body temperature, the sol is transformed into semi-solid gel, along with the slow dissolving of the carrier material, the medicines are released from the gel at the low rate, and the release of the medicines can last for several weeks to several months. The release ratio of the medicines can be realized by changing the variety, concentration, proportion and molecular weight of the gel material. The dosing interval of the gel is long, the preparation process is simple, the preparation process is mature, and the method is suitable for industrial mass production.
Owner:CHONGQING UNIV
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