56 results about "Dose interval" patented technology

The invention is directed to oral modified/controlled release drug formulations which provide a rapid initial onset of effect and a prolonged duration of effect. Preferably, the peak concentration is lower than that provided by the reference standard for immediate release formulations of the drug, and the duration of effect falls rapidly at the end of the dosing interval.

The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.

The invention provides methods for administering a therapeutically effective amount of daptomycin while minimizing skeletal muscle toxicity. The methods provide daptomycin administration at a dosing interval of 24 hours or greater. This long dosing interval minimizes skeletal muscle toxicity and allows for higher peak concentrations of daptomycin, which is related to daptomycin's efficacy. The invention also provides methods of administering lipopeptide antibiotics other than daptomycin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of the lipopeptide antibiotic at a dosage interval that does not result in muscle toxicity. The invention also provides methods of administering quinupristin/dalfopristin while minimizing skeletal muscle toxicity by administering a therapeutically effective amount of quinupristin/dalfopristin at a dosage interval that dos not result in muscle toxicity.

In one embodiment, the invention comprises a tray insert for a medication dispenser, the dispenser permitting access to a medication dose after a minimum dosing interval has elapsed since presentation of an immediately previous dose. The dispenser comprises a dispenser cover having an opening through which a patient accesses the medication dose presented through the opening and a carousel for receiving the tray insert. The tray insert comprises a substrate, a plurality of medication retention areas in the substrate each for holding at least one medication dose, each medication retention area received within a depression of the carousel and a cover removably affixed to an upper surface of the substrate for retaining the medication doses in the medication retention areas prior to use, wherein after the tray insert is mated with the carousel the cover.

The present disclosure provides an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.

The present invention discloses a method for treating or preventing a bone disorder in a mammal in need thereof comprising orally administering to said mammal a pharmaceutically effective amount of a pharmaceutical composition of at least one bisphosphonate, or a pharmaceutically acceptable salt or esters thereof, and at least one aminoalky methacrylate copolymer, according to a dosing schedule having a dosing interval selected from once-weekly dosing, twice-monthly dosing, once-monthly, once-quarterly and once-annually dosing. The present invention further discloses a method for treating or preventing a bone disorder in a mammal in need thereof comprising continuously orally administering a unit dosage per-day to said mammal in a short time for a long time therapy.

The present invention comprises methods and compositions for immunotherapy. An aspect of the invention comprises administration of one or more allergens in compositions via oral and sublingual routes. Allergen compositions are administered in dosing intervals wherein the increase in the one or more allergens administered to the patient are provided in increasing volumes of a single concentration of at least one allergen.

The invention relates to a preparation method of an SRB (sulfate reducing bacterium) biological inhibitor, which comprises the following steps: by taking polyvinyl alcohol, sodium alginate, denitrifying bacterium suspension, calcium carbonate, boric acid, calcium chloride, silicon dioxide and water as raw materials, preparing an embedding agent, then preparing a microbial mixed solution, and finally preparing to obtain immobilized denitrifying bacterium balls. The prepared SRB biological inhibitor can be used in the inhibition of SRB in crude oil. Sodium nitrate particles are firstly added into an oil well casing port; then, the SRB biological inhibitor is added; and finally, water is added to flush the two chemicals to the bottom of a well, and the dosing interval of each time is 15 days, thus achieving the purpose of inhibiting the growth of SRB for a long time. According to the invention, by using the sodium nitrate particles to provide a nitrogen source for the denitrifying bacteria, an oil layer origin and exogenous denitrifying bacterium microorganisms are activated, and the original and exogenous microorganisms are utilized to change the growth environment of the system so as to quickly inhibit the growth of SRB in the oil well, thereby inhibiting the generation of hydrogen sulfide gas from the source and reducing corrosion and sulfide hazard caused by SRB.

The invention relates to novel ceftriaxone sodium for injection and a preparation method thereof, and belongs to the technical field of medicines. The novel ceftriaxone sodium for injection consists of 1 part of ceftriaxone sodium, 0.30 to 0.33 part of ethyecellulose, 0.60 to 0.72 part of a stabilizer, 0.80 to 0.90 part of a surfactant, 70 to 80 parts of liquid paraffin and 0.27 to 0.30 part of ananti-sticking agent. The stabilizer p-dioxanone-lactide copolymer is a copolymer with a specific proportion, and plays an important role in preparation stability. According to the injection, the drugdelivery application twice every day becomes once administration through slow-release effect of a micro-capsule, the dosing interval is shortened, the injection is convenient to use, the biological availability is improved, the using amount of medicine is reduced, the curative effect is improved since the blood concentration is smooth, and the untoward effect is reduced. The novel ceftriaxone sodium for injection, provided by the invention, is simple in preparation technology and low in cost, is applicable for large-scale production, and is a product with very good market prospects.