The invention belongs to the technical field of combustion of internal combustion engines, and particularly relates to a dual-fuel engine adopting main and auxiliary oil injectors and manifolds for multiple times of spraying, and a combustion organization method of the dual-fuel engine. The dual-fuel engine comprises a piston, an air cylinder sleeve, an air cylinder cover, the main oil injector, the auxiliary oil injector, a manifold low-pressure gas jetting device and the like; the main oil injector is mounted at the center of the air cylinder cover, and the diesel injection ratio during thelow load can be controlled by changing the oil spraying pulse width of the main oil injector; the auxiliary oil injector is obliquely mounted on the air cylinder cover, diesel micro-jet is conducted during the middle and high load, and natural gas is ignited after diesel nearby a top dead center is self-ignited; and a manifold low-pressure gas jetting valve is mounted on the gas inlet manifold ofeach cylinder, during the middle and high load, the number of times of jetting and the timing of the low-pressure gas jetting valves are controlled, and thus reasonable mixed gas concentration distribution is formed in the cylinders. According to the dual-fuel engine, ignition stability under different working conditions is ensured through diesel ignition, and different oil and gas jetting strategies are adopted under the different working conditions, so that reasonable oil and gas distribution is achieved in the cylinders to achieve the good combustion effect, and thus the economical efficiency and emission performance of the engine are improved.